Influence of mesenchymal stem cells on tumor cells of breast cancer in non-contact co-cultivation

Authors

  • Олена Михайлівна Перепелиціна DBTPD of Institute of Cryobiology and Cryomedicine of NAS of Ukraine 42/1 Nauki ave., Kyiv, Ukraine, 03028, Ukraine https://orcid.org/0000-0002-5485-658X
  • Олена Вікторівна Ястребова DBTPD of Institute of Cryobiology and Cryomedicine of NAS of Ukraine 42/1 Nauki ave., Kyiv, Ukraine, 03028, Ukraine https://orcid.org/0000-0003-3937-2461
  • Сергій Васильович Безуглий DBTPD of Institute of Cryobiology and Cryomedicine of NAS of Ukraine 42/1 Nauki ave., Kyiv, Ukraine, 03028, Ukraine https://orcid.org/0000-0003-4827-7140
  • Михайло Васильович Сидоренко DBTPD of Institute of Cryobiology and Cryomedicine of NAS of Ukraine 42/1 Nauki ave., Kyiv, Ukraine, 03028, Ukraine https://orcid.org/0000-0003-1474-4898

DOI:

https://doi.org/10.15587/2313-8416.2015.51365

Keywords:

mesenchymal stem cells, estrogen receptor, EGFR, cytokeratin, E-cadherin

Abstract

In the present work were determined the kinetic parameters of the growth of human tumor cells (MCF-7) in vitro when co-cultured with MSCs, estimated levels of expression of some tumor markers by tumorigenic cells (estrogen receptor, EGF receptor, cytokeratin and E-cadherin) under the influence of human MSCs, and conducted a comparative analysis of the above parameters at different stages of cultivation in suspension and adhesion culture fractions

Author Biographies

Олена Михайлівна Перепелиціна, DBTPD of Institute of Cryobiology and Cryomedicine of NAS of Ukraine 42/1 Nauki ave., Kyiv, Ukraine, 03028

PhD, Senior Researcher

Laboratory morphogenetic factors microenvironment

Олена Вікторівна Ястребова, DBTPD of Institute of Cryobiology and Cryomedicine of NAS of Ukraine 42/1 Nauki ave., Kyiv, Ukraine, 03028

PhD, Researcher

Laboratory morphogenetic factors microenvironment

Сергій Васильович Безуглий, DBTPD of Institute of Cryobiology and Cryomedicine of NAS of Ukraine 42/1 Nauki ave., Kyiv, Ukraine, 03028

Ph.D., Junior Researcher

Laboratory diagnosis of the state of morphogenesis

Михайло Васильович Сидоренко, DBTPD of Institute of Cryobiology and Cryomedicine of NAS of Ukraine 42/1 Nauki ave., Kyiv, Ukraine, 03028

PhD, Head of the Laboratory

Laboratory diagnosis of the state of morphogenesis

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Published

2015-10-29

Issue

Vol. 10 No. 6 (15) (2015)

Section

Biological sciences

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Copyright (c) 2015 Олена Вікторівна Ястребова, Олена Михайлівна Перепелиціна, Сергій Васильович Безуглий, Михайло Васильович Сидоренко

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