Non-alcoholic steatohepatitis as a new factor of developing ischaemic heart disease
Keywords:соronary artery disease (CAD), non-alcoholic steatohepatitis (NASH), coronary arteries calcification, lipid blood spectrum
Aim of the study was to determine risk factors and prognosis for соronary artery disease (CAD) course in patients with non-alcoholic steatohepatitis (NASH) due to a comprehensive study of clinical manifestations, instrumental and laboratory indicators of cardiovascular system and liver functions and their correlation.
Methods. The object of the study involved 315 patients with CAD undergoing standard therapy according to guidelines of European Society of Cardiology.
The diagnosis of CAD was verified by the results of electrocardiography, echocardiography, multispiral computed tomography due to the recommendations of Ukrainian Association of Cardiology and European Society of Cardiology.
Results. The analysis of the study findings proved that multivascular damage of coronary flow prevails in case of comorbidity of diseases. It was determined that the degree of coronary arteries calcification is higher in patients with NASH and there is a correlation with TG (r=0,65), LDL (r=0,67), СRP (r=0,61).
Conclusions. Considerable changes of lipid blood spectrum and inflammation markers were observed in patients with CAD and NASH in comparison with patients without hepatic damage
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