DOI: https://doi.org/10.15587/2313-8416.2015.53995

The special features of cardiovascular pathology diagnostics in patients with epilepsy

Татьяна Анатольевна Литовченко, Валерия Николаевна Гримайло, Игорь Николаевич Пасюра, Анна Анатольевна Новикова

Abstract


Aim. The researchers noticed the changes of parameters of cardiovascular system functioning in patients with epilepsy during epileptic attacks and in interictal period. The aim of research was the study of informativity of the different methods of study of cardiovascular system functioning for detection and evaluation of risk of cardiac pathology development in patients with epilepsy.

Materials and methods. We examined 50 patients with epilepsy and CVP and 50 patients with epilepsy without CVP. All patients underwent clinical and neurological examination, electrocardiography, echocardioscopy, examination of heart rhythm variability, dopplerography of carotid arteries, analysis of lipid blood spectrum, brain evaluation on indications on SCORE, МРТ.

Results. There was revealed that the use of valproates and carbamazepine is associated with dyslipidemia development; valproates – with increase of intima-media complex thickness, cambamazepine – with increased risk of development of heart rhythm and conduction disorder; lamotrigine and levetiracetam – with increase of heart rate. The combined use of levetiracetam and carbamazepine is associated with extension of QT interval. The most significant increase of risk of CVP development during the next 10 years on SCORE was noticed in patients who take carbamazepine.

Conclusions. The definition of intima-media complex thickness at dopplerography of carotid arteries, patients evaluation on SCORE, lipidograms, heart rhythm variability, definition of myocardial work index at echocardioscopy along with the standard ECG are effective for determination of risk factors and early detection of CVP in patients with epilepsy


Keywords


epilepsy; cardiovascular pathology; myocardial work index; antiepileptic preparations; cardiovascular risk

References


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GOST Style Citations


1. Карлов, В. А. Эпилепсия у детей и взрослых, женщин и мужчин [Текст] / В. А. Карлов. – Руководство для врачей. – М.: ОАО «Изд. Медицина», 2010. – 720 с.

2. Nagaraddi, V. Autonomic seizures: localizing and lateralizing value [Text] / V. Nagaraddi; O Lüders (Ed.). – Textbook of Epilepsy Surgery, 2008. – Р. 443–449. doi: 10.3109/9780203091708-59

3. So, E. L. What is known about the mechanisms underlying SUDEP? [Text] / E. L. So // Epilepsia. – 2008. – Vol. 49. – Р. 93–98. doi: 10.1111/j.1528-1167.2008.01932.x

4. Shorvon, S. The Treatment of Epilepsy [Text] / S. Shorvon, E. Perucca, J. Engel. – Third Edition. – Blackwell Publishing Ltd, 2009. – 840 р.

5. Cardiol, J. Autonomic dysfunction presenting as postural tachycardia syndrome following traumatic brain injury [Text] / J. Cardiol, B. Karabin, Y. Kanjwal, B. P. Grubb // Cardiol. J. – 2010. – Vol. 17, Issue 5. – Р. 482–487.

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7. Jansen, K. Cardiac changes in epilepsy [Text] / K. Jansen, L. Lagae // Seizure. – 2010. – Vol. 19, Issue 8. – Р. 455–460. doi: 10.1016/j.seizure.2010.07.008

8. Alireza, B. Significant postictal hypotension: Expanding the spectrum of seizure-induced autonomic dysregulation [Text] / A. Bozorgi, S. Chung, F. Kaffashi, K. A. Loparo, S. Sahoo, G. Q. Zhang et. al // Epilepsia. – 2013. – Vol. 54, Issue 9. – P. e127–e130. doi: 10.1111/epi.12251

9. Philippe, R. Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study [Text] /  R. Philippe, N. Lina, D. L. Samden et. al // The Lancet Neurology. – 2013. – Vol. 12, Issue 10. – Р. 966–977.

10. Sauer, A. Long QT syndrome in adults [Text] / A. Sauer // J. Am. Coll. Cardiol. – 2007. – Vol. 49, Issue 3. – Р. 329–337. doi: 10.1016/j.jacc.2006.08.057







Copyright (c) 2015 Валерия Николаевна Гримайло, Татьяна Анатольевна Литовченко, Игорь Николаевич Пасюра, Анна Анатольевна Новикова

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ISSN 2313-8416 (Online), ISSN 2313-6286 (Print)