Role of beta1-adrenoreceptors at visual associative cortex in rats of different age in the impact on autonomous regulation of the heart rate ander low atmospheric pressure
Keywords:beta1-Adrenergic receptors, decreased atmospheric pressure, heart autonomic regulation, associative cortex
The role of beta1-adrenoreceptors at visual associative cortex in rats of different age in the impact on autonomous regulation of the heart rate ander low atmospheric pressure was investigated. The aim of the study was to check expediency of application nebivolol to prevent the adverse effects of hypoxic environment, the pressure conditions similar to the third type of weather.
Methods. In the experimental group cardiointervalography recorded in the intact condition before hypoxia, after hypoxic exposure, after trepanation of the skull and applying the solution beta1-blocker nebivolol (0.5 mg / kg) through the trepanation hole on the surface of the cerebral cortex (there were separate groups with right-sided and left-sided trepanation in projection of cortical areas Oc2L), with subsequent automatic analysis of data on a personal computer. In the control group a similar procedure of the experiment was carried out excepting hypoxic exposure. Effect of hypoxic atmosphere was created by reducing pressure by 50.76 hPa (0.05 atm) in the Komovsky’s device and hold the anesthetized rat under a glass bell for 1 hour.
Results. In juvenile, adult and old intact rats beta1-receptor structures in left and right associative cortical fields Oc2L are included to the neural circuits that provide growth of functional strenuousness in regulation of heart rhythm. After hypoxic exposure beta1-adrenoreceptors in the left field Oc2L are included in other neural circuits, and take part in limiting the functional strenuousness in regulation of heart rhythm.
Conclusions. Experimental results about effectiveness of therapeutic doses of beta-1 adrenoblockers especially nebivolol in adult and old age for prevention of unfavorable effects of hypoxic medium that corresponds to the baric conditions of 111type weather are to be verified by the clinical observations
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