DOI: https://doi.org/10.15587/2313-8416.2015.57208

Застосування абсорбційної спектрофотометрії для кількісного визначення гідрохлоротіазиду у лікарських засобах (огляд літератури)

Світлана Олександрівна Аніщенко, Наталія Юріївна Бевз, Вікторія Акопівна Георгіянц

Аннотация


Фармацевтична галузь постійно потребує чутливих, селективних, експресних, відносно дешевих методів контролю якості препаратів, тому вдосконалення існуючих і розробка нових методів кількісного визначення лікарських речовин є важливим.

Мета. Метою наших досліджень є вивчення літературних даних щодо методик кількісного визначення гідрохлоротіазиду в монопрепаратах та комбінованих лікарських засобах із застосуванням абсорбційної спектрофотометрії в ультрафіолетовій (УФ) та видимій області спектру.

Методи. Аналітичний огляд літературних джерел інформації щодо застосування абсорбційної спектрофотометрії в УФ та видимій області спектру для кількісного визначення гідрохлоротіазиду в лікарських засобах.

Результати. У результаті аналізу літературних джерел встановлено, що спектрофотометричні методики широко застосовуються для кількісного визначення гідрохлоротіазиду в лікарських засобах. Ці методики є достатньо чутливими, експресними, не потребують використання дорогих реактивів та обладнання. Дозволяють проводити аналіз без попереднього розділу сумішей у випадку комбінованих лікарських засобів в лікарських засобах.

Висновки. Наведені дані свідчать про те, що спектрофотометричні методи кількісного визначення гідрохлоротіазиду в лікарських засобах можуть бути застосовані у вдосконаленні існуючих та розробці нових, більш оптимальних методик контролю якості, таких, що відповідають вимогам Державної Фармакопеї України (ДФУ)


Ключевые слова


артеріальна гіпертензія; фармацевтичний аналіз; гідрохлоротіазид; спектрофотометрія; комбіновані лікарські форми; субстанція

Полный текст:

PDF (Українська)

Литература


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