Functional myocardial state and the special features of left ventricle remodeling at chronic heart failure with diabetes mellitus type 2 on the background of overweight and obesity based on gender factor
Keywords:heart failure, diabetes mellitus, obesity, gender, functional state, myocardium remodeling
Today chronic heart failure (CHF) is one of the main causes of death of patients with obesity and at the growth of body mass index (BMI) for every 1kg /m2 the risk of CHF increases by 5 % in men and by 7 % in women. There were proved that in the conditions of diabetes mellitus (DM) type 2 the mortality from cardiovascular pathology and especially CHF increases in 2-3 times in men and in 3-5 times in women. The aim of research was to study the myocardium functional state and the special features of the left ventricle (LV) remodeling at chronic heart failure (CHF) with diabetes mellitus (DM) type 2 on the background of overweight and obesity depending on gender factor.
Methods: there were examined 97 patients with CHF of I-III functional class at DM type 2 on the background of the normal body mass, overweight and abdominal obesity of I-III stage. All patients underwent echocardiographic examination. The processing of received data was carried out by the methods of nonparametric statistics.
Results: There was not revealed any reliable difference of index of LV ejection fraction that was a little less in men. The value of the mean pressure of pulmonary artery was almost equal and the prevalence of pulmonary hypertension unreliably predominated in men. The frequency of LV isolated systolic dysfunction (LVSD) in both groups did not essentially differ and LV diastolic dysfunction (LVDD) that was presented by myocardium relaxation disorder unreliably predominated in women. The percentage of combination of LVSD and LVDD had a tendency to increase in men. There was revealed reliable predominance of the frequency of LV hypertrophy (by 11 %) in women that in most cases was presented by its concentric type. The concentric LV remodeling observed in minority of patients unreliably predominated in men.
Conclusions: The myocardium functional changes at CHF with DM type 2 on the background of overweight and obesity are characterized with tendency to decrease of LV contractile ability, prevalence of pulmonary hypertension and predominance of systolic and diastolic dysfunction combination in men. Myocardium remodeling is presented by concentric type of LV hypertrophy and is more often registered in women
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