Determination of the level of spontaneous and induced chromosome abnormalities in peripheral blood lymphocytes of patients with juvenile rheumatoid arthritis

Authors

  • Олена Вікторівна Медзяновська Institute for Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine 52-a Jubilee ave. (50 years of the Komsomol ave.), Kharkiv, Ukraine, 61153, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2016.60318

Keywords:

chromosomal aberrations, juvenile rheumatoid arthritis, peripheral blood lymphocytes, model mutagen

Abstract

It has been found increase the spontaneous level of chromosomal disorders (by 2.6 times) in the blood lymphocytes of patients with juvenile rheumatoid arthritis, as compared with healthy. Our study has established the increase level of chromosomal abnormalities in the blood lymphocytes in vitro depending on the clinical course options, the activity of the pathological process, applied therapy and patient’s age. Model mutagen caused an increase in the general level of chromosomal aberrations

Author Biography

Олена Вікторівна Медзяновська, Institute for Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine 52-a Jubilee ave. (50 years of the Komsomol ave.), Kharkiv, Ukraine, 61153

Medical Genetics Laboratory

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Published

2016-02-26

Issue

Section

Biological sciences