DOI: https://doi.org/10.15587/2313-8416.2016.63344

Gene regulation of telomere length in human peripheral blood lymphocytes in early and remote perods after irradiation

Ірина Миколаївна Ільєнко, Димитрій Анатолійович Базика

Abstract


Radiation-associated violations of gene regulation of lymphocytes telomere length in early and late period after exposure are investigated. In Chernobyl clean-up workers in the range of doses more than 500 mSv was set reduction of relative telomere length and imbalance in TERF1, TERF2 gene expression on the background of p53-mediated activation of telomerase activity. The early period after professional exposure in“Shelter” object characterized by impairment of protective function of telomeres


Keywords


gene expression; TERF1; TERF2; TERT; telomere; ionizing radiation; Chernobyl; "Shelter" object

References


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GOST Style Citations


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