Technology of synbiotic bacterial drug production
DOI:
https://doi.org/10.15587/2313-8416.2016.67577Keywords:
bifidobacteria, lactobacillus, lactitol, consortium, symbiosis, synbiotic, simultaneous deep cultivation, acid production activity, bacterial drugAbstract
Aim. To increase the range of synbioltic drugs, technology for the complex bacterial drug production and methods for its quality control were developed.
Methods. For the high-effective remedy development, determination of type of bacteria symbiotic relationship in its composition was carried out. Considering the individuality of each strain in their requirements for nutrients in growth medium, its optimal composition was selected, which allows to carry out simultaneous deep cultivation of bacteria strains, maintaining both morphological features and activity of each strain. Determination of physical and technological cultivation parameters considers the bacteria exponential growth phase and allows maintaining active growth parameters. To improve the bacteria growth parameters, a prebiotic component, having equally high bifidobacteria and lactogenic effects, was included.
Results. Technology of the complex remedy production and its quality control methods were developed.
Conclusion. The obtained results in relation to the developed remedy quality control in experiments in vitro and in vivo confirm the compliance of the obtained drug to quality and safety requirements
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