Psychopathological and pathopsychological features of depressive disorders in patients with schizophrenia

Authors

  • Наталія Олександрівна Марута “Institute of Neurology, Psychiatry and Narcology National Academy of Medical Science of Ukraine” 46 Academic Pavlov str., Kharkiv, Ukraine, 61068, Ukraine https://orcid.org/0000-0002-6619-9150
  • Галина Юріївна Каленська “Institute of Neurology, Psychiatry and Narcology National Academy of Medical Science of Ukraine” 46 Academic Pavlov str., Kharkiv, Ukraine, 61068, Ukraine https://orcid.org/0000-0002-1473-6292
  • Ліана Володимирівна Малюта “Institute of Neurology, Psychiatry and Narcology National Academy of Medical Science of Ukraine” 46 Academic Pavlov str., Kharkiv, Ukraine, 61068, Ukraine https://orcid.org/0000-0001-9873-1087

DOI:

https://doi.org/10.15587/2313-8416.2016.67640

Keywords:

schizophrenia, depressive disorders, syndrome complex, pathopsychological features, clinical-psychopathological features, duration of disease

Abstract

Analysis of the modern literature on the problem of depressive disorders in schizophrenia structure demonstrated that despite the acceptance of the important role of depressive disorders at schizophrenia there are no single opinion about its place, clinical assessment, therapy, prognostic value for today and the conclusions of different authors on this problem are ambiguous and contradictory that proves that the researches of this direction are timely.

Aim of research – to study the clinical-psychopathological and pathopsychological features of depressive disorders in patients with schizophrenia for improvement of diagnostics of this pathology.

Materials and methods. 120 patients with schizophrenia and depressive symptomatology in the clinical picture took part in research. They were divided into 3 groups according to the aim of research: 38 patients with schizophrenia with the duration of disease less than 5 years (I group), 39 patients with the duration of disease 7-8 years (II group) and 43 patients with duration of disease more than 13 years (III group).

For realization of the aim were used the following methods: clinical-psychopathological that included the assessment of psychic state of patient (collection of complaints, anamnesis, its psychopathological interpretation); Calgary depression scale schizophrenia (CDSS); WHO brief questionnaire of the quality of life (WHOQOL- BREF); questionnaire of the social isolation “The method of evaluation of the suicide risk”, “Self-actualization test” and method of statistical processing of the received data.

Results of research. At the research was studied and described the syndrome structure of depression at schizophrenia and pathopsychological features of demonstration of depression at schizophrenia. There was shown that at the different stages of disease depression undergo the significant changes: anxious and obsessive syndrome complexes with time lose its emotional specificity and transform into apathetic-adynamic and anesthetic syndromes. In the process of disease dystrophic and depressive-paranoid syndromes come to the forefront.

Conclusions. In the result of research was revealed the negative dynamics of demonstration of the depressive symptoms at schizophrenia, the level of social isolation, suicide risk, life quality, alexithymia and self-appraisal depending on duration of disease

Author Biographies

Наталія Олександрівна Марута, “Institute of Neurology, Psychiatry and Narcology National Academy of Medical Science of Ukraine” 46 Academic Pavlov str., Kharkiv, Ukraine, 61068

Professor, Doctor of Medical Sciences, Deputy Director on Research Work

State Establishment 

Галина Юріївна Каленська, “Institute of Neurology, Psychiatry and Narcology National Academy of Medical Science of Ukraine” 46 Academic Pavlov str., Kharkiv, Ukraine, 61068

Senior scientific fellow

Ліана Володимирівна Малюта, “Institute of Neurology, Psychiatry and Narcology National Academy of Medical Science of Ukraine” 46 Academic Pavlov str., Kharkiv, Ukraine, 61068

Young scientific fellow

References

Bubnova, Ju. S., Dorofejkov, V. V., Mazo, G. Je., Petrova, N. N. (2012). K voprosu o mehanizmah razvitija depressii pri shizofrenii. Psihiatrija i psihofarmakoterapija, 4, 23–28.

Maruta, N. A. (2007). Pervyj jepizod psihoza (diagnostika, lechenie, organizacija pomoshhi). Ukrains'kij vіsnik psihonevrologіi, 15 (1), 21–24.

Naprjejenko, O. K., Procyk, V. O., Pampuha, L. S. (2006). Shyzofrenija z symptomamy depresii': klinichni projavy ta likuvannja tiorylom (tiorazydonom). Ukrai'ns'kyj visnyk psyhonevrologii', 14 (1), 90–92.

Smulevich, A. B., Il'ina, N. A. (2012). Koncepcii shizofrenii – sovremennye podhody – ocenki i diskussii (po materialam XV Vsemirnogo kongressa po psihiatrii, Bujenos-Ajres, 18–22 sentjabrja 2011 g.). Psihiatrija i psihofarmakoterapija, 1, 35–38.

Mazo, G. Je. (2005). Depressivnye narushenija v klinike jendogennyh psihozov (kliniko-farmakoterapevticheskoe issledovanie). Moscow, 44.

Kinkul'kina, M. A. (2007). Depressii, razvivajushhiesja u bol'nyh shizofreniej posle kupirovanija ostrogo psihoticheskogo sostojanija – klinika i lechenie. Moscow, 54–65.

Siris, S. G., Bench, C.; Hirsch, S., Weinberger, D. (Eds.) (2003). Depression and schizophrenia. Schizophrenia. Blackwell Science, Malden. Massachusetts, 142–167. doi: 10.1002/9780470987353.ch9

Tapp, A., Kilzieh, N., Wood, A. E., Raskind, M., Tandon, R. (2001). Depression in patients with schizophrenia during an acute psychotic episode. Comprehensive Psychiatry, 42 (4), 314–318. doi: 10.1053/comp.2001.24577

Kushnir, Ju. A. (2012). K voprosu differencial'noj diagnostiki postshizofrenicheskoj depressii. Arh. Psihіatrіi, 19 (4), 19–27.

Addington, D., Addington, J., Maticka-Tyndale, E., Joyce, J. (1992). Reliability and validity of a depression rating scale for schizophrenics. Schizophrenia Research, 6 (3), 201–208. doi: 10.1016/0920-9964(92)90003-n

Programme on Mental Health / World Health Organization WHOQOL-bref Introduction, Administration, Scoring and Generic Version of the Assessment (1996). Geneve, 18.

Fetiskin, N. P., Kozlov, V. V., Manujlov, G. M. (2002). Social'no-psihologicheskaja diagnostika razvitija lichnosti i malyh grupp. Moscow: Izd-vo Instituta Psihoterapii, 490.

Gavenko, V. L. et. al (2001). Pat. 40454A, MPK7 A61V 10/00. Sposib vyznachennja sui'cydal'nogo ryzyku. 2001021010. zajavl. 13.02.2001; opub. 2001; Bjul. № 6.

Rajgorodskij, D. Ja. (2001). Prakticheskaja psihodiagnostika. Metodiki i testy. Samara: Izdatel'skij Dom «BAHRAH-M», 672.

Smulevich, A. B. (2003). Psihopatologija i klinika depressij, razvivajushhihsja pri shizofrenii. Psihiatrija i psihofarmakoterapija, 5 (5), 4–7.

Published

2016-04-29

Issue

Section

Medical