DOI: https://doi.org/10.15587/2313-8416.2016.69763

Peculiarities of osteoarthritis in rats

Maria Drahulian, Tamara Gulko, Rostislav Bubnov, Polina Buchek, Dmitry Irodov, Ruslan German, Mikhail Levkiv, Svetlana Kostenko

Abstract


Was received model of osteoarthritis in the rat line Wistar, by a one-time injection of CH3COOI acid into the knee joint. There changes in joint studied histological and clinical methods.On the 7-th day of the experiment was installed resemblance to similar changes in the joints of humans with acquired osteoarthritis


Keywords


osteoarthritis; modeling; rats; CH3COOI acid; knee; cartilage

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References


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GOST Style Citations


1. Bendele, A. M. Animal models of osteoarthritis [Text] / A. M. Bendele // Musculoskel Neuron Interact. – 2001. – Vol. 1, Issue 4. – Р. 363–376.

2. Use of peptide compounds for treating non-inflammatory pain. Eurasian Patent Office, the IPC A61K 31/165 (2006.01), A61P 21/00 (2006.01), A61P 19/00 (2006.01) [Text] / Beyroyter B., Shtёr T.; SCHWARZ PHARMA AG (DE). – № 200800614, appl. 18.08.2006; publ. 30.12.2010; Byul. № 24.

3. Fathudinov, T. H. Reparative osteogenesis during prenatal xenotransplantation of multipotent mesenchymal stromal cells and human chondroblasts [Text]: author. dis. ... cand. med. science / T. H. Fathudinov. – Moscow, 2006. – 22 p.

4. Gulko, T. P. Peculiarities of osteoarthritis in rats [Text]: conference / T. P. Gulko, M. V. Drahulian, M. Y. Levkiw et. al // Biodiversity. Ecology. Adaptation. Evolution. – Odessa, 2013. – P. 267–268.

5. Riordan, N. Stem Cell Therapy for Osteoarthritis / N. Riordan // Stem Cell Institute. – 2012. – Available at: http://www.cellmedicine.com/treatment/osteoarthritis/

6. Treatment of osteoarthritis [Electronic resource]. – Institute of cellular therapy, 2004–2011. – Available at: http://www.stemcellclinic.com/ru/clinic/treatment/3.html

7. Dragulyan, M. V. Ultrasound-Controlled Osteoarthritis Model in Rats [Text] / M. V. Dragulyan, T. P. Gulko, R. V. Bubnov et. al // Slovak Journal of Health Scinces. – 2012. – Vol. 3, Issue 2. – Р. 107–108.

8. Liu, X. X. Experimental study on replicating knee osteoarthritis by modified Hulth's modeling method [Text] / X. X. Liu, X. H. Li, J. T. Zhou // Zhongguo Zhong Xi Yi Jie He Za Zhi. – 2005. – Vol. 25, Issue 12. – P. 1104–1108.

9. Fickert, S. Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers [Text] / S. Fickert, J. Fiedler, R. E. Brenner // Arthritis Research & Therapy. – 2004. – Vol. 6, Issue 5. – P. R422–R432. doi: 10.1186/ar1210

10. Noshyn, O. How to understand the analysis of blood [Electronic resource] / O. Noshyn // Portal childish. – 2012. – Available at: http://www.detsko.com/stati/mamam/jak-roz-bratis-u-anal-z-krov.html

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Copyright (c) 2016 Maria Drahulian, Tamara Gulko, Rostislav Bubnov, Polina Buchek, Dmitry Irodov, Ruslan German, Mikhail Levkiv, Svetlana Kostenko

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ISSN 2313-8416 (Online), ISSN 2313-6286 (Print)