The special features of cardiovascular pathology diagnostics in patients with epilepsy

Authors

  • Татьяна Анатольевна Литовченко Kharkiv Medical Academy of Postgraduate Education 58 Korchagintsev str., Kharkiv, Ukraine, 61176, Ukraine
  • Валерия Николаевна Гримайло Kharkiv Medical Academy of Postgraduate Education 58 Korchagintsev str., Kharkiv, Ukraine, 61176, Ukraine https://orcid.org/0000-0002-6002-6275
  • Игорь Николаевич Пасюра Central clinical hospital "Ukrzaliznici" 5 Balakirev lane, Kharkiv, Ukraine, 61103, Ukraine
  • Анна Анатольевна Новикова Central clinical hospital "Ukrzaliznici" 5 Balakirev lane, Kharkiv, Ukraine, 61103, Ukraine https://orcid.org/0000-0002-2166-7280

DOI:

https://doi.org/10.15587/2313-8416.2015.53995

Keywords:

epilepsy, cardiovascular pathology, myocardial work index, antiepileptic preparations, cardiovascular risk

Abstract

Aim. The researchers noticed the changes of parameters of cardiovascular system functioning in patients with epilepsy during epileptic attacks and in interictal period. The aim of research was the study of informativity of the different methods of study of cardiovascular system functioning for detection and evaluation of risk of cardiac pathology development in patients with epilepsy.

Materials and methods. We examined 50 patients with epilepsy and CVP and 50 patients with epilepsy without CVP. All patients underwent clinical and neurological examination, electrocardiography, echocardioscopy, examination of heart rhythm variability, dopplerography of carotid arteries, analysis of lipid blood spectrum, brain evaluation on indications on SCORE, МРТ.

Results. There was revealed that the use of valproates and carbamazepine is associated with dyslipidemia development; valproates – with increase of intima-media complex thickness, cambamazepine – with increased risk of development of heart rhythm and conduction disorder; lamotrigine and levetiracetam – with increase of heart rate. The combined use of levetiracetam and carbamazepine is associated with extension of QT interval. The most significant increase of risk of CVP development during the next 10 years on SCORE was noticed in patients who take carbamazepine.

Conclusions. The definition of intima-media complex thickness at dopplerography of carotid arteries, patients evaluation on SCORE, lipidograms, heart rhythm variability, definition of myocardial work index at echocardioscopy along with the standard ECG are effective for determination of risk factors and early detection of CVP in patients with epilepsy

Author Biographies

Татьяна Анатольевна Литовченко, Kharkiv Medical Academy of Postgraduate Education 58 Korchagintsev str., Kharkiv, Ukraine, 61176

Medical Doctor, Professor

Head of the Department of Neurology and Childhood Neurology

Валерия Николаевна Гримайло, Kharkiv Medical Academy of Postgraduate Education 58 Korchagintsev str., Kharkiv, Ukraine, 61176

Clinical ordinator

Department of Neurology and Childhood Neurology

Игорь Николаевич Пасюра, Central clinical hospital "Ukrzaliznici" 5 Balakirev lane, Kharkiv, Ukraine, 61103

Candidate of Medical Sciences

Head of the department of the inflammatory and traumatic nervous system diseases 

Анна Анатольевна Новикова, Central clinical hospital "Ukrzaliznici" 5 Balakirev lane, Kharkiv, Ukraine, 61103

Functional diagnostics doctor

Department of functional diagnostics

References

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Published

2015-11-27

Issue

Section

Medical