The use of absorption spectroscopy for quantitative determination of hydrochlorothiazide in remedies (literature review)

Authors

  • Світлана Олександрівна Аніщенко National University of Pharmacy 53 Pushkynskaya str., Kharkov, Ukraine, 61002, Ukraine
  • Наталія Юріївна Бевз National University of Pharmacy 53 Pushkynskaya str., Kharkov, Ukraine, 61002, Ukraine
  • Вікторія Акопівна Георгіянц National University of Pharmacy 53 Pushkynskaya str., Kharkov, Ukraine, 61002, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2015.57208

Keywords:

arterial hypertension, pharmaceutical analysis, hydrochlorothiazide, spectroscopy, combination dosage forms, substance

Abstract

Pharmaceutical industry always needs sensitive, selective, express, and relatively cheap methods for the quality control of drugs; therefore, the improvement of existing and development of new methods for the quantitative determination of medicinal substances is important.

Aim. The purpose of our research is the study of literature data about methods for the quantitative determination of hydrochlorothiazide both in single-component and combination remedies by the method of UV-Vis absorption spectroscopy.

Methods. Analytical review of the literature sources about the use of UV-Vis absorption spectroscopy for the quantitative determination of hydrochlorothiazide in remedies.

Results. As a result of the literature data analysis it has been found that spectroscopy methods are widely used for the quantitative determination of hydrochlorothiazide in remedies. These methods are sufficiently sensitive, express, and require neither expensive reagents, nor equipment. Besides, they allow permitting analysis without previous division of mixtures in the case of combination drugs research.

Conclusion. The displayed data show that spectroscopy methods for the quantitative determination of hydrochlorothiazide in remedies can be applied in the improvement of existing and development of new, more optimal quality control methods appropriate to the State Pharmacopoeia of Ukraine requirements

Author Biographies

Світлана Олександрівна Аніщенко, National University of Pharmacy 53 Pushkynskaya str., Kharkov, Ukraine, 61002

Researcher

Department of Pharmaceutical Chemistry

Наталія Юріївна Бевз, National University of Pharmacy 53 Pushkynskaya str., Kharkov, Ukraine, 61002

Candidate of Pharmaceutical Sciences, Associate Professor

Department of Pharmaceutical Chemistry 

Вікторія Акопівна Георгіянц, National University of Pharmacy 53 Pushkynskaya str., Kharkov, Ukraine, 61002

Doctor of Pharmaceutical Sciences, Professor

Department of Pharmaceutical Chemistry 

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Published

2015-12-29

Issue

Section

Pharmaceutical Sciences