Mechanism of anthracycline cardiotoxicity and analysis of mechanisms of cardioprotective effect of drugs and compounds of various chemical groups
DOI:
https://doi.org/10.15587/2313-8416.2016.67662Keywords:
anthracycline antibiotics, doxorubicin, cardiotoxicityAbstract
Aim. Research of the main directions of the search of cytoprotectors under anthracycline antibiotics intoxication conditions for the further development and study of new potential cardioprotectors.
Methods. The authors used synthesis and analysis method as the general scientific. Structural and functional, logical and semantic methods were used, as well as system and content analysis method.
Results. Certain mechanisms of cardiotoxicity development, including oxidative stress development, activation of lipid peroxidation, antioxidants reduction, inhibition of nucleic acids and proteins synthesis, biogenesis disorder and mitochondrial fragmentation, etc., simultaneously causing the death of cardiomyocytes by necrosis and apoptosis activation, were studied. Among the offered potential cardioprotectors, known remedies of different chemical groups (Cardioxan, Carvedilol, Metformin, Telmisartan, Spironolactone, Trimetazidine, Phenytoin, Indole-3-Carbinol, etc.), biologically active substances of animal and plant origin were examined, and mechanisms of their action under anthracycline intoxication were offered. Nevertheless, despite numerous studies of potential cardioprotectors, at present time there is no specific clinical guideline for cardiomyopathy prevention after anthracycline antibiotics application, and cardiovascular diseases take first place among population mortality and disability causes in developed countries.
Conclusion. Development and study of substances with optimal pharmacodynamic effects and pharmacokinetic parameters for myocardium structural and functional disorders correction are relevant and promising areas of research
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