State of humoral link of immune system in children with mono- and mixed-variants of rotavirus infection

Authors

DOI:

https://doi.org/10.15587/2313-8416.2015.50227

Keywords:

acute intestinal infections, rotavirus infection, diarrhea, humoral immunity, immunoglobulin A, immunoglobulin M, immunoglobulin G, children, immune system

Abstract

Connection of an immune system with infection agents defines the further development of infectious diseases especially rotavirus infection (RVI). The state of immune system before the beginning of disease and an adequacy of immune answer to causative agent defines the possibility of disease and its heaviness, duration of an acute period, cyclicity, time of pathogens elimination and period of reconvalescence. The humoral link is one of important components of immune system.

Methods. 96 children 1 month-5 years old with acute intestinal infections of rotavirus etiology were under observation. 51 children with mono-variant of rotavirus infection formed the 1 group. The 11 group included 45 patients with mixed-variant of rotavirus infection. The control group included 32 practically healthy children. The research was carried out at the high point of disease (1–3 day) and in period of reconvalescence. (5–6 day). The study of humoral link of immunity was carried out using the method of radial immunodiffusion in agar on Mancini G.

Results. At comparison of indicators of the humoral link of immune system in children with mono- and mixed-variants of RVI at admission to hospital it was established that Ig М concentration in children of the 1 group was higher (р<0,05), and Ig G level in blood serum lower(р<0,05) than in the 11 group. So the study of the humoral immunity in blood serum in children with rotavirus infection revealed changes that were presented as an increase of Ig М and IgG indicators and also decrease of IgА. An assessment of an immune system after treatment within this research is characterized with an increase of IgА and IgG and decrease of IgМ.

Conclusions. In blood serum of children with mono- and mixed-variants of rotavirus infection in an acute period of disease there was observed decrease of Ig А concentration and increase of Ig М і IgG. In the period of reconvalescence in children with mono- and mixed-variants of an acute intestinal infection of rotavirus etiology the humoral link of immune system is characterized with a tendency to increase of Ig М, there was no improvement on the other indicators. At comparative characteristic of the studied groups it was established that in children with mono-variant of rotavirus infection was detected the reliable decrease of immunoglobulin M concentration and increase of immunoglobulin G comparing with mixed-variant of rotavirus gastroenteritis

Author Biographies

Катерина Олександрівна Сміян-Горбунова, Sumy State University 28 Troitska str., Sumy, Ukraine, 40022

Postgraduate student

The chair of paediatrics of post-graduate education with the courses of propedeutics paediatrics and childhood infection diseases

Тетяна Парфеніївна Бинда, Sumy State University 28 Troitska str., Sumy, Ukraine, 40022

PhD, Associate Professor

The chair of paediatrics of post-graduate education with the courses of propedeutics paediatrics and childhood infection diseases

Олександр Іванович Сміян, Sumy State University 28 Troitska str., Sumy, Ukraine, 40022

Doctor of Medical Sciences, Professor

The chair of paediatrics of post-graduate education with the courses of propedeutics paediatrics and childhood infection diseases

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Published

2015-09-28

Issue

Section

Medical