Hidradenitis suppurativa successfully treated with adalimumab

Authors

  • Iqbal A. Bukhari College of Medicine University of Dammam and King Fahd Hospital of the University King Fahd Hospital of the University 40189 str., Alkhobar, Saudi Arabia, 31952, Saudi Arabia
  • Abdulaziz Al Zahrani King Abdulaziz Hospital, Al Ahsa 2477 str., Al Ahsa, Kingdom of Saudi Arabia, 31982, Saudi Arabia

DOI:

https://doi.org/10.15587/2313-8416.2015.51530

Keywords:

Hidradenitis suppurativa, biologics, apocrine glands, adalimumab

Abstract

Aim: To discuss the new beneficial effect of adalimumab in the management of hidradenitis suppurativa(HS).

Case: We report a 25-year-old arabic female with a 14-year history with long-standing poorly controlled active hidradenitis suppurativa who was successfully treated with adalimumab.

Discussion: Hidradenitis suppurativa is a skin disorder characterized by the formation of multiple cysts, abscesses and sinus tracts in apocrine gland-bearing areas. The aetiology and pathogenesis of HS are unknown. Current medical and surgical therapies are only minimally effective at treating the disease. The biologic agent Adalimumab is a new promising agent for the treatment of HS.

Conclusion: The biologic agent adalimumab is an effective treatment for HS

Author Biographies

Iqbal A. Bukhari, College of Medicine University of Dammam and King Fahd Hospital of the University King Fahd Hospital of the University 40189 str., Alkhobar, Saudi Arabia, 31952

Doctor of Medical Sciences

Dermatology Department

Abdulaziz Al Zahrani, King Abdulaziz Hospital, Al Ahsa 2477 str., Al Ahsa, Kingdom of Saudi Arabia, 31982

Doctor of Medical Sciences

Internal Medicine Department

References

Velpeau, A. A.; Bechet J. Z. (Ed.) (1839). Dictionnaire de médecine, un repertoire générale des Sciences Medicals sous le rapport theorique et pratique. Paris, 2, 1839–1891.

Brunsting, H. A. (1939). Hidradenitis suppurativa; abscess of apocrine sweat glands a study of the clinical and pathologic features with a report of twenty-two cases and a review of the literature. Archives of Dermatology and Syphilology, 39 (1), 108–120. doi: 10.1001/archderm.1939.014801901110100

Pillsbury, D. M., Shelley, W. B., Kligman, A. M.; Pillsbury, D. M. (Ed.) (1956). Bacterial infections of the skin. Dermatology. Philadelphia: Saunders WB, 482–484.

Plewig, G., Kligman, A. M. (1975). Acne: Morphogenesis and Treatment. Berlin: Springer-Verlag, 192–193. doi: 10.1007/978-3-642-96246-2

Naldi, L.; Jemec, G., Revuz, J., Leyden, J. (Eds.) (2006). Hidradenitis suppurativa. Springer Berlin Heidelberg, 58–64. doi: 10.1007/978-3-540-33101-8

Jemec, G. B. E., Heidenheim, M., Nielsen, N. H. (1996). The prevalence of hidradenitis suppurativa and its potential precursor lesions. Journal of the American Academy of Dermatology, 35 (2), 191–194. doi: 10.1016/s0190-9622(96)90321-7

Revuz, J. (2009). Hidradenitis suppurativa. Journal of the European Academy of Dermatology and Venereology, 23 (9), 985–998. doi: 10.1111/j.1468-3083.2009.03356.x

Von der Werth, J., Wood, P., Irvine, A. D., McLean, W. H. I. (2006). Genetics of Hidradenitis Suppurativa. Hidradenitis Suppurativa, Berlin Heidelberg: Springer, 70–85. doi: 10.1007/978-3-540-33101-8_10

Alikhan, A., Lynch, P. J., Eisen, D. B. (2009). Hidradenitis suppurativa: A comprehensive review. Journal of the American Academy of Dermatology, 60 (4), 539–561. doi: 10.1016/j.jaad.2008.11.911

Mekkes, J. R., Bos, J. D. (2007). Long-term efficacy of a single course of infliximab in hidradenitis suppurativa. British Journal of Dermatology, 158 (2), 370–374. doi: 10.1111/j.1365-2133.2007.08332.x

Wolkenstein, P., Loundou, A., Barrau, K., Auquier, P., Revuz, J. (2007). Quality of life impairment in hidradenitis suppurativa: A study of 61 cases. Journal of the American Academy of Dermatology, 56 (4), 621–623. doi: 10.1016/j.jaad.2006.08.061

Short, K. A., Kalu, G., Mortimer, P. S., Higgins, E. M. (2005). Vulval squamous cell carcinoma arising in chronic hidradenitis suppurativa. Clinical and Experimental Dermatology, 30 (5), 481–483. doi: 10.1111/j.1365-2230.2005.01875.x

Weber, L. A., Kantor, G. R., Bergfeld, W. F. (1990). Reticulate pigmented anomaly of the flexures (Dowling-Degos disease): a case report associated with hidradenitis suppurativa and squamous cell carcinoma. Cutis, 45, 446–450.

Li, M., Hunt, M. J., Commens, C. A. (1997). Hidradenitis suppurativa, Dowling Degos disease and perianal squamous cell carcinoma. Australasian Journal of Dermatology, 38 (4), 209–211. doi: 10.1111/j.1440-0960.1997.tb01700.x

Talmant, J.-C., Bruant-Rodier, C., Nunziata, A. C., Rodier, J. F., Wilk, A. (2006). Dégénérescence de maladie de Verneuil en carcinome épidermoïde: à propos de 2 cas et revue de la littérature. Annales de Chirurgie Plastique Esthétique, 51 (1), 82–86. doi: 10.1016/j.anplas.2005.11.002

Maclean, G. M., Coleman, D. J. (2007). Three Fatal Cases of Squamous Cell Carcinoma Arising in Chronic Perineal Hidradenitis Suppurativa. The Annals of The Royal College of Surgeons of England, 89 (7), 709–712. doi: 10.1308/003588407x209392

Kurokawa, I., Nishimura, K., Yamanaka, K., Mizutani, H., Tsubura, A., Revuz, J. (2007). Cytokeratin expression in squamous cell carcinoma arising from hidradenitis suppurativa (acne inversa). Journal of Cutaneous Pathology, 34 (9), 675–678. doi: 10.1111/j.1600-0560.2006.00680.x

Barresi, V., Vitarelli, E., Barresi, G. (2008). Acne inversa complicated by squamous cell carcinoma in association with diffuse malignant peritoneal mesothelioma arising in the absence of predisposing factors: a case report. Journal of Cutaneous Pathology, 35 (1), 70–73. doi: 10.1111/j.1600-0560.2007.00766.x

Constantinou, C., Widom, K., Desantis, J., Obmann, M. (2008). Hidradenitis suppurativa complicated by squamous cell carcinoma. Am. Surg., 74, 1177–1181.

Katz, R. D., Goldberg, N. H. (2009). Marjolin Ulcer Arising Within Hidradenitis. Annals of Plastic Surgery, 62 (2), 173–174. doi: 10.1097/sap.0b013e31817d87b3

Giamarellos-Bourboulis, E. J., Antonopoulou, A., Petropoulou, C., Mouktaroudi, M., Spyridaki, E., Baziaka, F. et. al (2007). Altered innate and adaptive immune responses in patients with hidradenitis suppurativa. British Journal of Dermatology, 156 (1), 51–56. doi: 10.1111/j.1365-2133.2006.07556.x

Jemec, G. B. E., Wendelboe, P. (1998). Topical clindamycin versus systemic tetracycline in the treatment of hidradenitis suppurativa. Journal of the American Academy of Dermatology, 39 (6), 971–974. doi: 10.1016/s0190-9622(98)70272-5

Slade, D. E. M., Powell, B.W., Mortimer, P. S. (2003). Hidradenitis suppurativa: pathogenesis and management. British Journal of Plastic Surgery, 56 (5), 451–461. doi: 10.1016/s0007-1226(03)00177-2

Lebwohl, B., Sapadin, A. N. (2003). Infliximab for the treatment of hidradenitis suppurativa. Journal of the American Academy of Dermatology, 49 (5), 275–276. doi: 10.1016/s0190-9622(03)01132-0

Sullivan, T. P., Welsh, E., Kerdel, F. A., Burdick, A. E., Kirsner, R. S. (2003). Infliximab for hidradenitis suppurativa. British Journal of Dermatology, 149 (5), 1046–1049. doi: 10.1111/j.1365-2133.2003.05663.x

Adams, R., Gordon, K. B., Devenyi, A. G., Ioffreda, M. D. (2003). Severe hidradenitis suppurativa treated with infliximab infusion. Archives of Dermatology, 139 (12), 1540–1542. doi: 10.1001/archderm.139.12.1540

Mekkes, J. R., Hommes, D. W. (2004). Treatment of suppurative hidradenitis with surgical deroofing and infliximab. Ned. Tijdschr. Dermatol. Venereol., 14, 196–197.

Thielen, A.-M., Barde, C., Saurat, J.-H. (2006). Long-term infliximab for severe hidradenitis suppurativa. British Journal of Dermatology, 155 (5), 1105–1107. doi: 10.1111/j.1365-2133.2006.07528.x

Cusack, C., Buckley, C. (2006). Etanercept: effective in the management of hidradenitis suppurativa. British Journal of Dermatology, 154 (4), 726–729. doi: 10.1111/j.1365-2133.2005.07067.x

Campione, E., Mazzotta, A., Bianchi, L., Chimenti, S. (2006). Severe Acne Successfully Treated With Etanercept. Acta Dermato-Venereologica, 86 (3), 256–257. doi: 10.2340/00015555-004

Moul, D. K., Korman, N. J. (2006). Severe hidradenitis suppurativa treated with adalimumab. Archives of Dermatology, 142 (9), 1110–1112. doi: 10.1001/archderm.142.9.1110

Zouboulis, C. C.; Wolff, K., Goldsmith, L. A., Katz, S. I., Gilchrest, B. A., Paller, A. S., Leffell, D. J. (Eds.) (2009). Update on hidradenitis suppurativa/acne inversa. Fitzpatrick’s Dermatology in General Medicine. New York Chicago.

Downloads

Published

2015-10-25

Issue

Section

Medical Science. Part 1