Integral haematological indexes as predictors of antibacterial therapy usage advisability in patients with acute respiratory infections

Authors

DOI:

https://doi.org/10.15587/2313-8416.2015.51531

Keywords:

acute respiratory infections, integral hematological indexes, community-acquired pneumonia, antibacterial therapy

Abstract

There was considered a possibility to use IHI as predicators of bacterial factor presence and necessity to prescribe an antibacterial therapy.

Aim of research – to optimize the treatment of patients with ARI on the base of IHI calculation.

Methods. There were examined 163 patients with ARI. 97 (59,5 %) men, 66 (40,7 %) women. An uncomplicated clinical course of ARI was observed in 116 patients in 47 ones it was complicated with community-acquired pneumonia (CAP). IHI were detected in all patients it were calculated using mathematical formulas.

Results. There was detected that the more essential changes of IHI were observed at ARI complicated with CAP. An increase of complications coefficient (CC) was observed reliably more often (р<0,01).

Conclusions. 1. IHI in patients with ARI differ from indexes in healthy persons it represent the presence and intensity of intoxication. The more intense changes are observed at complicated clinical course.

2. CC is the most informative as predicator of bacterial complications and it allows recommend to take this index into account at resolving a question about necessity of antibacterial therapy in patients with ARI

Author Biography

Олена Іванівна Могиленець, Kharkiv national medical university 4 Lenina ave., Kharkiv, Ukraine, 61022

Candidate of medical sciences, Associate professor

The department of infectious diseases 

References

Unifikovanyj klinichnyj protokol pervynnoi' medychnoi' dopomogy doroslym ta ditjam. Gostri respiratorni infekcii' (2014). Infekcijna sduzhba Lugans'koi' oblasti. Available at: http://infekcionisti.at.ua/load/prikazy_i_protokoly/unifikovanij_klinichnij_protokol_pervinnoji_medichnoji_dopomogi_doroslim_ta_ditjam_gostri_respiratorni_infekciji/2-1-0-68

Voltchek, I. V. (1998). Novyje podchody k terapii bakterial’nych i virusnych infektsiy. Terra medica nova, 4, 11–15.

Burkhardt, O., Ewig, S., Haagen, U., Giersdorf, S., Hartmann, O., Wegscheider, K., Hummers-Pradier, E., Welte, T. (2010). Procalcitonin guidance and reduction of antibiotic use in acute respiratory tract infection. European Respiratory Journal, 36 (3), 601–607. doi: 10.1183/09031936.00163309

Simon, L., Gauvin, F., Amre, D. K., Saint-Louis, P., Lacroix, J. (2004). Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-analysis. Clinical Infectious Diseases, 39(2), 206–217. doi: 10.1086/421997

Aabenhus, R., Jensen, J.-U. S., Jørgensen, K. J., Hróbjartsson, A., Bjerrum, L.; Aabenhus, R. (Ed.) (1996). Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care. Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.cd010130.pub2

Schuetz, P., Briel, M., Christ-Crain, M., Wolbers, M., Stolz, D., Tamm, M., Bouadma, L. et. al. (1996). Procalcitonin to initiate or withhold antibiotics in acute respiratory tract infections. Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.cd007498.pub2

Tchystyakova, G. N., Gaziyeva, I. A., Remizova, I. I. (2005). Ispolzovaniye integralnych hematologicheskich indexov dlya otsenki stepeni autointoxikacii organisma pry oslozhnennoy gestozom beremennosti. Klinicheskaja laboratornaja diagnostika, 12, 34–37.

Vasil’yev, V. S., Komar, V. I., Tsyrkunov, V. M. (1994). Minsk: Vysh. schk., 495.

Mustaphina, J. G., Kramarenko, Yu. S., Kobtseva, V. Yu. (1998). Integralnyye hematologicheskiye o pokazateli v otsenke immunologitcheskoy reaktivnosti organisma u bol’nych s ophthal’mopatologiyey. Klinicheskaja laboratornaja diagnostika, 5, 47–49.

Juchorov, L. S., Voronaya Yu. L. (2002). Integralnyye pokazateli leykogrammy perifericheskoy krovi v otsenke nespetsyficheskoy immunologitcheskoy reaktivnosti u bolnych s ishemitcheskoy bolesnyu serdtsa. Klinicheskaja laboratornaja diagnostika, 12, 39–41.

Ostrovskij, V. K., Semenova, O. P., Mashhenko, A. V., Alimov, R. R., Kurapova, M. I. (2003). Nekotorye dannye o pokazateljah normy lejkocitarnogo indeksa intoksikacii. Klinicheskaja laboratornaja diagnostika, 1, 45–46.

Mohylenets, O. I. (2007). Kliniko-imunologichni pokaznyky ta mozhlyvist’ ych korectsiy u chvorych na gostri respiratorni zachvoryuvannya. State Establishment “Institute of Epidemiology and Infectious Diseases named after L.V. Gromashevsky AMS of Ukraine”. Kyiv, 23.

Published

2015-10-25

Issue

Section

Medical Science. Part 1