Non-alcoholic steatohepatitis as a new factor of developing ischaemic heart disease
DOI:
https://doi.org/10.15587/2313-8416.2015.52369Keywords:
соronary artery disease (CAD), non-alcoholic steatohepatitis (NASH), coronary arteries calcification, lipid blood spectrumAbstract
Aim of the study was to determine risk factors and prognosis for соronary artery disease (CAD) course in patients with non-alcoholic steatohepatitis (NASH) due to a comprehensive study of clinical manifestations, instrumental and laboratory indicators of cardiovascular system and liver functions and their correlation.
Methods. The object of the study involved 315 patients with CAD undergoing standard therapy according to guidelines of European Society of Cardiology.
The diagnosis of CAD was verified by the results of electrocardiography, echocardiography, multispiral computed tomography due to the recommendations of Ukrainian Association of Cardiology and European Society of Cardiology.
Results. The analysis of the study findings proved that multivascular damage of coronary flow prevails in case of comorbidity of diseases. It was determined that the degree of coronary arteries calcification is higher in patients with NASH and there is a correlation with TG (r=0,65), LDL (r=0,67), СRP (r=0,61).
Conclusions. Considerable changes of lipid blood spectrum and inflammation markers were observed in patients with CAD and NASH in comparison with patients without hepatic damage
References
Horbas', I. M., Barna, O. M., Sakalosh, V. Yu. et. al. (2010). Otsinka poshyrenosti ta kontrolyu faktoriv ryzyku sertsevo-sudynnykh zakhvoryuvan' sered naselennya ta likariv. Liky Ukrayiny, 1, 4–9.
Anders, K., Baum, U., Schmid, M., Ropers, D., Schmid, A., Pohle, K. et. al. (2006). Coronary artery bypass graft (CABG) patency: Assessment with high-resolution submillimeter 16-slice multidetector-row computed tomography (MDCT) versus coronary angiography. European Journal of Radiology, 57 (3), 336–344. doi: 10.1016/j.ejrad.2005.12.018
Sklyarov, Ye. Ya., Kit, Z. M., Yarema, Ya. I. (2010). Vplyv ursodyzoksykholevoyi kysloty na deyaki pokaznyky lipidnoho spektru krovi, L-arhininu, oksyd azotu ta endotelin-1 u patsiyentiv z AH ta ozhyrinnyam. Kryms'kyy terapevtychnyy zhurnal, II (2), 154–158.
Mel'nykova, N. V., Zvenyhorodskaya, L. A., Khomeryky, S. H. (2004). Klynyko-byokhymycheskye yzmenenyya y morfolohycheskye osobennosty pecheny u bol'nykh s dyslypydemyey. Hepatolohyya, 3, 18–21.
Korkushko, O. V., Lyshnevskaya, V. Yu., Bodretskaya, L. A. (2007). Predyktori chastoy supraventrykulyarnoy ekstrasystolyy u bol'nikh starshe 60 let s yshemycheskoy bolezn'yu serdtsa (rezul'tati 3-letneho nablyudenyya). Ukr. kardiol. zhurnal, 4, 32–35.
Parkhomenko, A. N. (2008). Klynycheskoe znachenye dopolnenyy k rekomendatsyyam po lechenyyu ynfarkta myokarda s podъemom sehmenta ST. Ukrayins'kyy kardiolohichnyy zhurnal, dodatok 3, 4–9
Steinberg, D. (2006). The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy, part V: The discovery of the statins and the end of the controversy. Journal of Lipid Research, 47, 1339–1351.
Geetha, A., Surendran, R. (2005). Effect of ursodeoxycholic acid on copper induced oxidation of low density lipoprotein. Pharmazie, 60 (8), 609–613.
Chen, C.-H., Nien, C.-K., Yang, C.-C., Yeh, Y.-H. (2009). Association Between Nonalcoholic Fatty Liver Disease and Coronary Artery Calcification. Digestive Diseases and Sciences, 55 (6), 1752–1760. doi: 10.1007/s10620-009-0935-9
Assy, N., Djibre, A., Farah, R. et. al. (2010). Presence of coronary plaques in patients with nonalcoholic fatty liver disease. Radiology, 254 (2), 393–400.
Akabame, S., Hamaguchi, M., Tomiyasu, K., Tanaka, M., Kobayashi-Takenaka, Y., Nakano, K. et. al. (2007). Evaluation of Vulnerable Coronary Plaques and Non-Alcoholic Fatty Liver Disease (NAFLD) by 64-Detector Multislice Computed Tomography (MSCT). Circulation Journal, 72 (4), 618–625. doi: 10.1253/circj.72.618
Arslan, U., Tаkolu, S., Balciolu, S., Tavil, Y., Karakan, T. et. al. (2007). Association between nonalcoholic fatty liver disease and coronary artery disease. Coronary Artery Disease, 18 (6), 433–436. doi: 10.1097/mca.0b013e3282583c0d
Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology (2006). European Heart Journal, 27 (11), 1341–1381. doi: 10.1093/eurheartj/ehl001
American Gastroenterological Association medical positionstatement: Nonalcoholicfatty liverdisease (2002). Gastroenterology, 123, 1702–1704.
Dolzhenko, М. М., Bazylevych, A. Ya., Sharayevskyj, O. A. (2011). Diahnostyka nealkoholnoyi zhyrovoyi xvoroby pechinky u xvoryx z ishemichnoyu xvoroboyu sercya za dopomohoyu kompyuternoyi tomohrafiyi. Liky Ukrayiny, 7, 76–78.
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