@article{Dotsenko_Romanko_Vashchyk_Zakhariev_Zemlianskyi_Dotsenko_Seliukova_2021, title={The effect of a formulation based on maduramycin and nicarbazine on rats and broiler chickens in a subacute experiment}, url={https://journals.uran.ua/sr_bio/article/view/241245}, DOI={10.15587/2519-8025.2021.241245}, abstractNote={<p><strong>The aim:</strong> to determine the effect of a preparative form of an antiemeric agent based on maduramycin and nicarbazine on the body of white rats and broiler chickens under the conditions of a subacute experiment.</p> <p><strong>Materials and methods.</strong> The formulation based on maduramycin and nicarbazine was administered to rats and broiler chickens with feed for 28 days. One control and three experimental groups were formed for the experiment: Group I – animals received a complete diet without admixture of the formulation (control group), Group II – animals that were administered the formulation (by the amount of active substances) at a dose of 5.0 mg / kg, III – 25.0 mg / kg and IV – 50.0 mg / kg of feed, respectively. In order to establish the toxic effect of the formulation on the body of experimental birds on 7, 14, 28 days of the experiment and 7 days after discontinuation of the formulation, 5 heads from each group were killed under light ether anesthesia, blood samples were taken for hematological and biochemical studies.</p> <p><strong>Results.</strong> During the study of the general clinical condition of rats and broiler chickens of the experimental groups, no significant changes in behavior and appearance were detected, compared with the control.</p> <p>Hematological parameters of broiler chickens it was found that the receipt of the formulation with feed at doses of 5, 25 and 50 mg/kg body weight, causes a decrease in hemoglobin and an increase in hematocrit in broiler chickens on day 7 of the experiment. It was found that the changes are reversible, on the 28th day of the experiment the value of these indicators was within the physiological norm.</p> <p>In the study of hematological and biochemical parameters of rats, it was found that the receipt of the formulation with food in doses of 25.0 and 50.0 mg/kg for 28 days, causes a decrease in hemoglobin and increase hematocrit, total protein, albumin, creatinine and urea in male rats on the 7th day of the experiment.</p> <p><strong>Conclusions.</strong> Under conditions of repeated oral administration of the preparation mixture to rats and poultry at doses of 5, 25 and 50 mg/kg body weight in the absence of clinical signs of poisoning, insignificant fluctuations in hematological and biochemical parameters were identified</p>}, number={3 (28)}, journal={ScienceRise: Biological Science}, author={Dotsenko, Roman and Romanko, Maryna and Vashchyk, Yevheniia and Zakhariev, Andriy and Zemlianskyi, Andrii and Dotsenko, Ekaterina and Seliukova, Nataliia}, year={2021}, month={Sep.}, pages={41–48} }