ScienceRise: Biological Science <p>«ScienceRise: Biological Science» – scientific peer-reviewed journal, published 4 times a year, included in category “B” «List of scientific professional editions of Ukraine» for specialty 091-Biology (Сertificated by order of Ministry of Education and Science of Ukraine No. 612 from 07.05.2019) and for specialty 211- Veterinary medicine (Сertificated by order of Ministry of Education and Science of Ukraine No. 320 from 07.04.2022).</p> <p>The aim of «ScienceRise: Biological Science» is to provide scientists with a platform for sharing scientific progress in all aspects of biological and veterinary sciences and to do it at the highest level. Articles published in the journal will be interesting for both scientists who focus on theoretical issues and researchers who specialize more in applied and practical aspects.</p> <p>«ScienceRise: Biological Science» is an open access journal that publishes original research and literature reviews on all issues of biological and veterinary sciences.</p> <p><a href="">ISSN 2519-8017 </a> (print), <a href="">ISSN 2519-8025 </a>(on-line) <br /><br />Drawing up the items of the publication ethics policy of the journal «ScienceRise: Biological Science» Editors followed the recommendations of Committee on Publication Ethics<a href=""> (COPE)</a>.</p> РС ТЕСHNOLOGY СЕNTЕR en-US ScienceRise: Biological Science 2519-8017 <p>Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.</p> <p>Authors, who are published in this journal, agree to the following conditions:</p> <p>1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.</p> <p> 2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.</p> Peculiarities of suction, extraction and assignment of calcium in experimental chronic hepatitis in rats <p><strong>The aim. </strong>Study the degree of absorption, assimilation, and excretion of calcium in rats with chronic toxic hepatitis.</p> <p><strong>Materials and methods.</strong> The studies were carried out on 1 month old Wistar rats. Toxic hepatitis in the experimental group was reproduced by intraperitoneal injection of hydrazine sulfate at a dose of 50 mg / kg twice a week. Studies of the absorption of substances in rats were carried out under thiopental anesthesia according to the Tyri method after 3 months of pathology modelling. In the intestinal contents, the amount of unabsorbed calcium and amino acids was determined. To determine the amount of assimilated and excreted calcium metabolic chambers were used for daily collection of urine, faeces and food residues, in which the calcium content was determined (average for three days per animal). After removing the rats from the experiment, the level of calcium in the blood serum was determined, in the bone tissue – the degree of its resorption by the activity of acid phosphatase and the content of calcium.</p> <p><strong>Results and discussion</strong>. Toxic hepatitis reduced calcium absorption by 34.5 % in the small intestine of rats and did not have a significant effect on amino acids, the inhibition of absorption of which in hepatitis was only 5.5 %. The excretion of calcium in the urine of rats with toxic hepatitis was reduced by 1.8 times, and with faeces, on the contrary, increased by 1.5 times. As a result, calcium absorption in rats with hepatitis decreased by 24.2 %. Decreased absorption of calcium, and its increased excretion in the faeces, led to a decrease in the level of this element in the blood of animals with hepatitis by 14.7 %. Our studies found bone destruction in rats with hepatitis: an increase in bone acid phosphatase activity by 65.3 % and a decrease in calcium levels by 15.5 %.</p> <p><strong>Conclusion</strong>. The triggering mechanism for the development of hepatic osteodystrophy is the inhibition of calcium absorption in the small intestine of rats with hepatitis, consequently - a decrease in its absorption and level in the blood, which ultimately leads to the activation of bone resorption. The established patterns will form the basis of the pathogenetic scheme for the prevention of hepatic osteodystrophy</p> Tatiana Mogilevskaya Olga Makarenko Larissa Khromagina Copyright (c) 2022 Tatiana Mogilevskaya, Olga Makarenko, Larissa Khromagina 2022-07-10 2022-07-10 2(31) 4 7 10.15587/2519-8025.2022.258790 Prevalence of internal diseases of dogs and cats: a retrospective analysis (1994–2014) <p><strong>The aim: </strong>to analyze the literature data for the period from 1992 to 2010 on the spread of internal diseases among dogs and cats.</p> <p><strong>Materials and methods.</strong> The research was conducted by the method of scientific literature open source analysis: PubMed, Elsevier, electronic resources of the National Library named after V.I. Vernadsky (1994–2014).</p> <p><strong>Results.</strong> In the practice of veterinary medicine, internal diseases are a significant part of other diseases of dogs and cats. According to research by domestic authors, a significant number of scientific issues in the study of internal diseases of both productive and non-productive animals remain unclear. Recently, significant progress has been made in the study of internal diseases of dogs, developed methods of their medical examination. Also in recent years, Ukrainian scientists have conducted fundamental research on domestic diseases of domestic cats – urolithiasis, chronic renal failure, glomerulonephritis, polycystic kidney disease, liver lipidosis. Foreign researchers most often diagnose the following internal diseases in dogs and cats among the pathologies of the respiratory, digestive, endocrine and urinary systems: chronic renal failure, glomerulonephritis, diabetes, chronic hepatitis and cholangiohepatitis, gastrointestinal and bronchial diseases. Diagnostic studies of animals with internal pathology are carried out using clinical, instrumental and laboratory methods. According to the scientific works of foreign scientists, the problem of diagnosis and treatment of diabetes is taken care of by scientists around the world, including veterinary medicine, so the problem of diabetes in domestic cats is very relevant in modern science and practice.</p> <p><strong>Conclusions.</strong> Thus, internal diseases are very common among dogs and cats, and the diagnosis and treatment of these pathologies needs further improvement. This is because the number of unproductive pets is constantly growing, and owners are increasingly seeking veterinary care. That is why there is a need to develop new advanced non-invasive and informative methods for diagnosing internal diseases based on biochemical and clinical and instrumental studies</p> Roman Dotsenko Yevheniia Vashchyk Andriy Zakhariev Andrii Zemlianskyi Nataliia Seliukova Kateryna Gliebova Lidiia-Mariia Kostyshyn Copyright (c) 2022 Roman Dotsenko, Yevheniia Vashchyk, Andriy Zakhariev, Andrii Zemlianskyi, Nataliia Seliukova, Kateryna Gliebova, Lidiia-Mariia Kostyshyn 2022-07-10 2022-07-10 2(31) 8 12 10.15587/2519-8025.2022.260493 The role of connective tissue biopolymers in the pathogenesis of dog bronchopneunmonia and cat brochnial asthma <p><strong>The aim: </strong>to analyze the pathogenetic role of connective tissue biopolymers in canine pneumonia and feline asthma.</p> <p><strong>Materials and methods. </strong>The study was conducted by analyzing the sources of scientific literature: PubMed, Elsevier, electronic resources of the National Library, named after V.I. Vernadsky and the results of our own scientific and clinical experience.</p> <p><strong>Results. </strong>Studies on the pathogenetic justification of the role of biochemical indicators of the connective tissue in the diagnosis and treatment of diseases of the respiratory system of dogs and cats were conducted. This is due to the need to expand knowledge about the peculiarities of the course, to determine the leading pathogenetic links of the most common pathologies –bronchopneumonia and bronchial asthma, which are found in clinical veterinary practice.</p> <p><strong>Conclusions. </strong>In bronchopneumonia of dogs on the background of severe clinical symptoms (cough, fever, wheezing in the lungs), radiological signs (inhomogeneous compaction of the lung tissue, lack of clear contours of the bronchi), anemic syndrome, general and neutrophilic leukocytosis, lymphocytopenia, hypoalbuminemia, dysproteinemia (increased concentration of α2- and β-globulins in the blood serum), hypercholesterolemia, hyper-β-lipoproteinemia, hyperfermentemia (increased activity of AST and alkaline phosphatase,) there is an increase in serum glycoproteins and chondroitin sulfates, sialic acids, total glycosaminoglycans (GAG) due to the chondroitin-4-sulfate fraction; urinary excretion of oxyproline and uronic acids increases. Disorders of connective tissue metabolism in dogs with bronchopneumonia are caused by an acute inflammatory process in the lungs with the development of pulmonary fibrosis.</p> <p>Bronchial asthma in cats is manifested by intermittent cough, shortness of breath, hypochromic normocytic anemia, leukocytosis, eosinophilia and lymphocytopenia, increased serum activity of AST and alkaline phosphatase, haptoglobin content, glial acid concentration sulfate; urinary excretion of oxyproline and uronic acids increases. Connective tissue disorders in cats with bronchial asthma are caused by increased mucus excretion with a high content of GAG, as well as chronic inflammation of the bronchial mucosa and their fibrosis</p> Dmytro Morozenko Roman Dotsenko Yevheniia Vashchyk Andriy Zakhariev Andrii Zemlianskyi Nataliia Seliukova Kateryna Gliebova Lidiia-Mariia Kostyshyn Copyright (c) 2022 Dmytro Morozenko, Roman Dotsenko, Yevheniia Vashchyk, Andriy Zakhariev, Andrii Zemlianskyi, Nataliia Seliukova, Kateryna Gliebova, Lidiia-Mariia Kostyshyn 2022-07-10 2022-07-10 2(31) 13 17 10.15587/2519-8025.2022.260749 Prevention of bronchopneumonia by the aerosol method and its influence on calf production indicators <p><strong>The aim</strong>: to determine the effectiveness of aerosol prophylaxis of nonspecific bronchopneumonia in calves by using a complex of biogenic compounds of macro- and microelements and plant immunomodulator Echinacea in the form of the drug Kalfmin on production indicators.</p> <p><strong>Materials and methods. </strong>The research was conducted in the farm "Podilsky owner 2004", v. Velyka Medvedivka, Shepetivka district, Khmelnitsky region on black-spotted calves, which were in the risk group for bronchopneumonia, taking into account certain technological components, namely – stress due to regrouping of animals, some adjustment of their feeding rations, some excess concentration of livestock animals in groups and other factors.</p> <p><strong>Results. </strong>The results of studies indicate a high therapeutic efficacy for the use of the drug "Kalfmin" group aerosol method in the treatment of patients with calf bronchopneumonia, as this drug enters the body in the same way as pathogens. It was found, that 40 % of calves in the control group, which did not receive preventive measures, have clinical signs of bronchopneumonia, and 10 % of cases were fatal. At the same time, signs of bronchopneumonia were found in only 10 % of calves in the experimental groups, who received aerosol prophylaxis according to the experimental scheme; their course was much easier and without fatal consequences.</p> <p><strong>Conclusions. </strong>Prevention of bronchopneumonia in young cattle should be comprehensive and aimed at eliminating violations of the technology of keeping, feeding and increasing the resistance of animals. Group aerosol prevention of nonspecific bronchopneumonia in calves using the drug Calfmin in combination with the plant immunomodulator Echinacea is a more promising and effective method of preventing this pathology compared with the use of turpentine, lactic acid and chlorinated lime. The use of the drug Kalfmin in combination with Echinacea is characterized by 1.60 time’s higher efficiency and 1.70 times shorter period of prevention of animals</p> Pavlo Sharandak Maryna Drobot Nataliia Druz Copyright (c) 2022 Pavlo Sharandak, Maryna Drobot, Nataliia Druz 2022-07-10 2022-07-10 2(31) 18 23 10.15587/2519-8025.2022.260754