The analysis of adhesive-dysfunctional endothely at resistant arterial hypertension

Authors

DOI:

https://doi.org/10.15587/2519-4798.2017.100135

Keywords:

resistant hypertension, adhesive endothelial dysfunction, Bisoprolol, Telmisartan, Aliskiren

Abstract

Aim: To examine the antihypertensive activity of Telmisartan and Bisoprolol at resistant hypertension.To evaluate the features of resistant hypertension and endothelial vasomotor and adhesive dysfunction.

Methods: The level of adhesion molecules s-ICAM-1, L-selectin and matrix metalloproteinase-9 was determined by ELISA with regard to vasoactive function of the brachial artery, which is determined through the flow-dependent vascular dilatation sample. Determination of Nitrogen oxide was conducted on data metabolites of total Nitrogen (NOx) by determination of Nitrite ion after colorimetric reaction with Griess reagent using SF-46 spectrometer (Russia).

Results. The studies have shown that six-month treatment by Telmisartan and Bisoprolol in most patients (22 patients) was accompanied by target levels of blood pressure achievement, and was observed in 14 patients resistant to the treatment. The additional inclusion in complex treatment Aliskiren 150-300 mg per day was also accompanied by normalization of blood pressure.

Conclusion.

1. The function of endothelial adhesion and appearance of endothelial dysfunction occur prior to hypertension clinical and morphological signs.

2. Induced hypertension increase of sICAM-1 and L-selectin and matrix metalloproteinase-9 is a marker of hypertension severity and the treatment efficiency.

3. Telmisartan and Bisoprolol significantly reduce the adhesive endothelial dysfunction and contribute to the achievement of target blood pressure levels

Author Biography

Ben Abid Mouna, Zaporizhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine Vintera blvd., 20, Zaporizhia, Ukraine, 69096

Postgraduate student

Department of General Practice of Family Medicine with courses of Dermatology and Psychiatry 

References

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Published

2017-04-29

How to Cite

Mouna, B. A. (2017). The analysis of adhesive-dysfunctional endothely at resistant arterial hypertension. ScienceRise: Medical Science, (4 (12), 33–35. https://doi.org/10.15587/2519-4798.2017.100135

Issue

No. 4 (12) (2017)

Section

Medical Science

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Copyright (c) 2017 Ben Abid Mouna

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