DOI: https://doi.org/10.15587/2519-4798.2017.105378

Ефективність полегшувального лікування нападу у школярів з фенотипом тяжкої бронхіальної астми

Mykola Garas, Gennadіy Lekhkun, Vladislav Lysenko, Basiuk Natalia

Анотація


У дослідженні показано, що триденний курс системних глюкокортикостероїдів порівняно з коротшим терміном їх призначення характеризувався вірогідним ризиком регресу бальної оцінки тяжкості нападу на 7-й день стаціонарного лікування. Також продемонстровано, що довенне введення еуфіліну на тлі застосування інгаляційних β2-агоністів короткої дії та системних глюкокортикостероїдів асоціювало з ризиком зменшення тяжкості нападу на 3-й та 7-й день стаціонарного лікування


Ключові слова


бронхіальна астма; фенотип; діти; лікування; тяжкість нападу; метилксантини; глюкокортикостероїди; β2-адреноміметики

Повний текст:

PDF (English)

Посилання


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Mallia, P., Johnston, S. L. (2006). How Viral Infections Cause Exacerbation of Airway Diseases. Chest, 130 (4), 1203–1210. doi: 10.1378/chest.130.4.1203

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Camargo, C. A., Rachelefsky, G., Schatz, M. (2009). Managing Asthma Exacerbations in the Emergency Department: Summary of the National Asthma Education and Prevention Program Expert Panel Report 3 Guidelines for the Management of Asthma Exacerbations. Proceedings of the American Thoracic Society, 6 (4), 357–366. doi: 10.1513/pats.p09st2

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Bacharier, L. B., Boner, A., Carlsen, K.-H., Eigenmann, P. A., Frischer, T. et. al. (2007). Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy, 63 (1), 5–34. doi: 10.1111/j.1398-9995.2007.01586.x

Greenberg, R. S., Daniels, S. R., Flanders, W. D. et. al. (2004). Medical Epidemiology. Norwalk: Appleton & Lange, 196.

Martinez, F. D. (2009). Managing Childhood Asthma: Challenge of Preventing Exacerbations. Pediatrics, 123 (3), 146–150. doi: 10.1542/peds.2008-2233d

Kim, C.-K., Koh, Y. Y., Callaway, Z. (2009). The Validity of Induced Sputum and Bronchoalveolar Lavage in Childhood Asthma. Journal of Asthma, 46 (2), 105–112. doi: 10.1080/02770900802604111

Cosio, B. G., Soriano, J. B. (2009). Theophylline again? Reasons for believing. European Respiratory Journal, 34 (1), 5–6. doi: 10.1183/09031936.00011309

Cosio, B. G., Iglesias, A., Rios, A., Noguera, A., Sala, E., Ito, K. et. al. (2009). Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD. Thorax, 64 (5), 424–429. doi: 10.1136/thx.2008.103432

Clinical Trial of Low-Dose Theophylline and Montelukast in Patients with Poorly Controlled Asthma (2007). American Journal of Respiratory and Critical Care Medicine, 175 (3), 235–242. doi: 10.1164/rccm.200603-416oc


Пристатейна бібліографія ГОСТ


Yadav, R. Factors Influencing Acute Exacerbation of Bronchial Asthma Among Children in Malaysia [Text] / R. Yadav, H. Yadav, T. Leong // International Journal of Child Health and Nutrition. – 2014. – Vol. 3, Issue 1. – P. 11–16. doi: 10.6000/1929-4247.2014.03.01.2

Pijnenburg, M. W. Monitoring asthma in children [Text] / M. W. Pijnenburg, E. Baraldi, P. L. P. Brand, K.-H. Carlsen, E. Eber, T. Frischer et. al. // European Respiratory Journal. – 2015. – Vol. 45, Issue 4. – P. 906–925. doi: 10.1183/09031936.00088814

Levine, S. J. Narrative Review: The Role of Th2 Immune Pathway Modulation in the Treatment of Severe Asthma and Its Phenotypes [Text] / S. J. Levine, S. E. Wenzel // Annals of Internal Medicine. – 2010. – Vol. 152, Issue 4. – P. 232–237. doi: 10.7326/0003-4819-152-4-201002160-00008

Hekking, P.-P. W. Developing and Emerging Clinical Asthma Phenotypes [Text] / P.-P. W. Hekking, E. H. Bel // Journal Allergy & Clinical Immunology. – 2014. – Vol. 2, Issue 6. – P. 671–680. doi: 10.1016/j.jaip.2014.09.007

Joos, G. F. Inflammatory airway diseases and clinical allergy Inflammatory Airways Diseases and Clinical Allergy Assembly contribution to the celebration of 20 years of the ERS [Text] / G. F. Joos, P. J. Barnes // European Respiratory Journal. – 2010. – Vol. 35, Issue 6. – P. 1197–1199. doi: 10.1183/09031936.00051510

Fitzpatrick, A. Severe Asthma in Children: Lessons Learned and Future Directions [Text] / A. Fitzpatrick // Journal of Allergy & Clinical Immunology. – 2016. – Vol. 4, Issue 1. – P. 11–19. doi: 10.1016/j.jaip.2015.10.008

Jackson, D. J. Asthma Exacerbation: origin, effect and prevention [Text] / D. J. Jackson, A. Sykes, P. Mallia, S. L. Johnston // Journal of Allergy Clinical Immunology. – 2011. – Vol. 128, Issue 6. – P. 1165–1174. doi: 10.1016/j.jaci.2011.10.024

Mallia, P. How viral infections cause exacerbation of airway diseases [Text] / P. Mallia, S. Johnston // Chest. – 2006. – Vol. 130, Issue 4. – P. 1203–1210. doi: 10.1378/chest.130.4.1203

Nievas, I. F. F. Severe Acute Asthma Exacerbation in Children: A Stepwise Approach for Escalating Therapy in a Pediatric Intensive Care Unit [Text] / Nievas, I. F. F., Anand, K. J. S. // The Journal of Pediatric Pharmacology and Therapeutics. – 2013. – Vol. 18, Issue 2. – P. 88–104. doi: 10.5863/1551-6776-18.2.88

Kanchongkittiphon, W. Indoor Environmental Exposures and Exacerbation of Asthma: An Update to the 2000 Review by the Institute of Medicine [Text] / W. Kanchongkittiphon, M. J. Mendell, J. M. Gaffin, G. Wang, W. Phipatanakul // Environmental Health Perspectives. – 2015. – Vol. 123, Issue 1. – P. 6–20. doi: 10.1289/ehp.1307922

Camargo, C. A. Managing Asthma Exacerbations in the Emergency Department. Summary of the National Asthma Education and Prevention Program Expert Panel Report 3 Guidelines for the Management of Asthma Exacerbations [Text] / C. A. Camargo, G. Rachelefsky, M. Schatz // Proceedings of the American Thoracic Society. – 2009. – Vol. 6, Issue 4. – P. 357–366. doi: 10.1513/pats.p09st2

Lang, A. Asthma severity in childhood, untangling clinical phenotypes [Text] / A. Lang, P. Mowinckel, C. Sachs-Olsen, A. Riiser, J. Lunde, K.-H. Carlsen, K. C. Lodrup Carlsen // Pediatric Allergy and Immunology. – 2010. – Vol. 21, Issue 6. – Р. 945–953. doi: 10.1111/j.1399-3038.2010.01072.x

Reddy, R. C. Severe asthma: approach and management [Text] / R. C. Reddy // Postgraduate Medical Journal. – 2008. – Vol. 84, Issue 989. – P. 115–120. doi: 10.1136/pgmj.2007.063479

Bezrukov, L. A. Diagnostika i lechenie ostryh pnevmonii i ORVI, oslozhnennyh BOS u detey rannego vozrasta [Text] / L. A. Bezrukov, Yu. N. Nechitaylo, S. A. Cherevko et. al.; A. F. Mozolevskogo (Ed.). – Chernivtsi, 1989. – 23 p.

FitzGerald, J. Global strategy for asthma management and prevention [Text] / J. FitzGerald, E. Bateman, J. Bousquet. – 2014. – Available at: www.ginasthma.org

Bacharier, L. B. Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report [Text] / L. B. Bacharier, A. Boner, K.-H. Carlsen, P. A. Eigenmann, T. Frischer et. al. // Allergy. – 2007. – Vol. 63, Issue 1. – P. 5–34. doi: 10.1111/j.1398-9995.2007.01586.x

Greenberg, R. S. Medical Epidemiology [Text] / R. S. Greenberg, S. R. Daniels, W. D. Flanders et. al. – Norwalk: Appleton & Lange, 2004. – 196 p.

Martinez, F. D. Managing Childhood Asthma: Challenge of Preventing Exacerbations Fernando [Text] / F. D. Martinez // Pediatrics. – 2009. – Vol. 123, Issue 3. – P. 146–150. doi: 10.1542/peds.2008-2233d

Kim, C.-K. The Validity of Induced Sputum and Bronchoalveolar Lavage in Childhood Asthma [Text] / C.-K. Kim, Y. Y. Koh, Z. Callaway // Journal of Asthma. – 2009. – Vol. 46, Issue 2. – P. 105–112. doi: 10.1080/02770900802604111

Cosio, B. G. Theophylline again? Reasons for believing [Text] / B. G. Cosio, J. B. Soriano // European Respiratory Journal. – 2009. – Vol. 34, Issue 1. – P. 5–6. doi: 10.1183/09031936.00011309

Cosio, B. G. Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD [Text] / B. G. Cosio, A. Iglesias, A. Rios, A. Noguera, E. Sala, K. Ito et. al. // Thorax. – 2009. – Vol. 64, Issue 5. – P. 424–429. doi: 10.1136/thx.2008.103432

Clinical Trial of Low-Dose Theophylline and Montelukast in Patients with Poorly Controlled Asthma [Text]. – American Journal of Respiratory and Critical Care Medicine. – 2007. – Vol. 175, Issue 3. – P. 235–242. 

doi: 10.1164/rccm.200603-416oc







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