Clinical significance of renal function worsening in patients with acute decompensated heart failure, depending on NGAL changes and initial renal function

Authors

DOI:

https://doi.org/10.15587/2519-4798.2017.112977

Keywords:

renal function worsening, acute decompensated heart failure, NGAL, decongestion

Abstract

Aim. To determine the value of the renal function worsening (RFW) depending on NGAL and initial renal dysfunction in so-called “wet and warm” patients with acute decompensated heart failure (ADHF).

Materials and methods. The prospective study included 141 patients with ADHF 38–85 years old (mean age 66,4±2,2), successively admitted to cardiologic department of Olexandrivska clinical hospital in Kyiv during 2012–2014, 38 patients had RFW, 67 patients underwent the assessment of NGAL in blood serum using enzymatic immune analysis for D1 and last D.

Results. RFW by creatinine was in 38 (27 %) of patients and it was absent in 103 (73 %) of patients. RFW group with the increased NGAL content differed from patients without RFW by the more occurrence of hypertonic disease, diabetes mellitus, ІHD and NYHA IV at admission (all p <0,05). At the analysis of patients with RFW depending on MDRD it was established, that patients with MDRD <60 and RFW were essentially older than patients with MDRD in both groups with MDRD > 60 (р <0,05-0,01).

Conclusions. RFW in patients with ADHF is connected with the increased intensity of symptoms only at association with NGAL increase in 48 hours. Patients with RFW without NGAL increased didn’t essentially differ from ones without RFW

Author Biographies

Kateryna Amosova, Bogomolets National Medical University Tarasa Shevchenka blvd.,, 13, Kyiv, Ukraine, 01601

MD, Professor, Rector, Corresponding Member NAMS of Ukraine

Igor Gorda, Bogomolets National Medical University Tarasa Shevchenka blvd.,, 13, Kyiv, Ukraine, 01601

Postgraduate student

Department of internal medicine No. 2

Andriy Bezrodnyi, Bogomolets National Medical University Tarasa Shevchenka blvd.,, 13, Kyiv, Ukraine, 01601

PhD, Associate Professor

Department of Internal Medicine No. 2 

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Published

2017-10-31

How to Cite

Amosova, K., Gorda, I., & Bezrodnyi, A. (2017). Clinical significance of renal function worsening in patients with acute decompensated heart failure, depending on NGAL changes and initial renal function. ScienceRise: Medical Science, (10 (18), 9–15. https://doi.org/10.15587/2519-4798.2017.112977

Issue

No. 10 (18) (2017)

Section

Medical Science

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Copyright (c) 2017 Kateryna Amosova, Igor Gorda, Andriy Bezrodnyi

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