Analysis of combination of chronic myeloproliferative and lymphoproliferative disease in one patient
DOI:
https://doi.org/10.15587/2519-4798.2019.161767Keywords:
myeloproliferative disease, lymphoproliferative disease, chronic lymphocytic leukemia, lymphoma, polycythemia, myelofibrosisAbstract
A review of the literature on the combination of chronic lymphoproliferative and chronic myeloproliferative disease in one patient, which are diagnosed simultaneously or in the treatment of an existing hematological nosology, was conducted. In this paper, in addition to a brief overview of current sources, five patients are presented with two diagnoses simultaneously: a combination of chronic myeloproliferative and chronic lymphoproliferative diseases. In three of them, on the background of true polycythemia, chronic lymphocytic leukemia was diagnosed (2 patients) after 1 and 8 years, the third - non-Hodgkin B-large-cell diffuse anaplastic CD-30-positive lymphoma, which was detected on the background of 5-year therapy for myeloproliferative pathology. One patient was simultaneously diagnosed with multiple myeloma and idiopathic myelofibrosis, in the other case – during the treatment of diffuse B-cell non-Hodgkin lymphoma of the mantle zone, essential thrombocythemia was diagnosed, which after 2 years transformed into idiopathic myelofibrosis. The aim of the work was to describe the cases when a chronic myeloproliferative and lymphoproliferative disease is present in one patient at the same time. These 5 patients were observed in the advisory clinic of the State Institution "Institute of Blood Pathology and Transfusion Medicine of the National Academy of Medical Sciences of Ukraine" in the period 2011-2018. Despite the rarity of a combination of chronic myeloproliferative and lymphoproliferative diseases, this possibility must be taken into account in order to avoid diagnostic errors. These patients require an individual approach to diagnosis, and the treatment of these patients is quite problematic and should be directed to the treatment of each disease separately
References
- Stijnis, C., Kroes, W. G. M., Balkassmi, S., Marijt, E. W. A., van Rossum, A. P., Bakker, E., Vlasveld, L. T. (2012). No Evidence for JAK2V617F Mutation in Monoclonal B Cells in 2 Patients with Polycythaemia Vera and Concurrent Monoclonal B Cell Disorder. Acta Haematologica, 128 (3), 183–186. doi: https://doi.org/10.1159/000338831
- Vyhovska, Ya. I., Buzherak, N. F., Lozynskyi, R. Yu. et. al. (2012). Poiednannia khronichnoho mieloproliferatyvnoho ta limfoproliferatyvnoho zakhvoriuvannia v odnoho patsienta. Opys klinichnoho vypadku. Ukrainskyi zhurnal hematolohiyi ta transfuziolohiyi, 5, 29–32.
- Henry, L., Carillo, S., Jourdan, E., Arnaud, A., Brun, S., Lavabre-Bertrand, T. (2007). Association of essential thrombocythemia and chronic lymphocytic leukemia: Absence of the V617F JAK2 mutation in the lymphoid compartment. American Journal of Hematology, 82 (6), 500–501. doi: https://doi.org/10.1002/ajh.20870
- Ghanem, S., Garcia, G., Ying, L., Hurford, M., Odaimi, M. (2016). Systemic Mastocytosis with Smoldering Multiple Myeloma: Report of a Case. Case Reports in Oncological Medicine, 2016, 1–6. doi: https://doi.org/10.1155/2016/3161768
- Chromik, K., Helbig, G., Dziaczkowska-Suszek, J., Kopińska, A., Woźniczka, K., Kyrcz-Krzemień, S. (2017). Indolent systemic mastocytosis associated with multiple myeloma: A rare coexistence. Acta Haematologica Polonica, 48 (4), 364–368. doi: https://doi.org/10.1016/j.achaem.2017.08.006
- Eskazan, A. E., Salihoglu, A., Diz-Kucukkaya, R., Hancer, V. S., Soysal, T. (2011). Chronic lymphocytic leukemia developing in a patient with Janus kinase 2 V617F mutation positive myeloproliferative neoplasm. Annals of Hematology, 91 (2), 305–306. doi: https://doi.org/10.1007/s00277-011-1256-6
- Kodali, S., Chen, C., Rathnasabapathy, C., Wang, J. C. (2009). JAK2 mutation in a patient with CLL with coexistent myeloproliferative neoplasm (MPN). Leukemia Research, 33 (12), e236–e239. doi: https://doi.org/10.1016/j.leukres.2009.06.027
- Musolino, C., Allegra, A., Penna, G., Centorrino, R., Cuzzola, M., D’Angelo, A. A. et. al. (2009). Absence of the V617F JAK2 Mutation in the Lymphoid Compartment in a Patient with Essential Thrombo- cythemia and B-Chronic Lymphocytic Leukemia and in Two Relatives with Lymphoproliferative Disorders. Acta Haematologica, 122 (1), 46–49. doi: https://doi.org/10.1159/000243721
- Laurenti, L., Tarnani, M., Nichele, I., Ciolli, S., Cortelezzi, A., Forconi, F. et. al. (2011). The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: A retrospective multicentric GIMEMA experience. American Journal of Hematology, 86 (12), 1007–1012. doi: https://doi.org/10.1002/ajh.22171
- Vannucchi, A. M., Masala, G., Antonioli, E., Chiara Susini, M., Guglielmelli, P., Pieri, L. et. al. (2009). Increased Risk of Lymphoid Neoplasms in Patients with Philadelphia Chromosome-Negative Myeloproliferative Neoplasms. Cancer Epidemiology Biomarkers & Prevention, 18 (7), 2068–2073. doi: https://doi.org/10.1158/1055-9965.epi-09-0353
- Tournilhac, O., Santos, D. D., Xu, L., Kutok, J., Tai, Y.-T., Le Gouill, S. et. al. (2006). Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling. Annals of Oncology, 17 (8), 1275–1282. doi: https://doi.org/10.1093/annonc/mdl109
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Copyright (c) 2019 Yaroslava Vygovska, Olha Boyko, Zvenyslava Masliak, Nataliya Pelenyo, Yuriy Karol
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