The polymorphisms of beta-adrenergic receptors genes and a risk of atrial fibrillation development in patients with a heart failure

Authors

  • Sergiy Pyvovar Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039, Ukraine https://orcid.org/0000-0003-3446-2767
  • Iurii Rudyk Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039, Ukraine https://orcid.org/0000-0002-3363-868X
  • Tatyana Lozyk Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039, Ukraine https://orcid.org/0000-0001-8188-1898
  • Valentina Galchinskaya Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039, Ukraine https://orcid.org/0000-0002-0024-131X
  • Tatiana Bondar Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039, Ukraine https://orcid.org/0000-0002-2501-317X

DOI:

https://doi.org/10.15587/2519-4798.2019.183384

Keywords:

atrial fibrillation, 1-adrenergic receptors, 2-adrenergic receptors, G-protein, heart failure, polymorphism, gene, risk

Abstract

Objective: to study the relationship of gene polymorphisms of the b-adrenoreception system with the risk of atrial fibrillation in patients with heart failure.

Material and methods. 286 patients with heart failure on the background of post-infarction cardiosclerosis were included. Of these, 25 (8.7 %) patients had the atrial fibrillation. The genotyping was performed using 4 polymorphisms (Gly389Arg of the b1-adrenoreceptors gene, Ser49Gly of the b1-adrenoreceptors gene, Gln27Glu of the b2-adrenoreceptors gene and Ser275 of the b3-subunit of G-protein gene) using the polymerase chain reaction. The genetic and epidemiological analysis was carried out using the SNPStats program.

Results. Patients with heart failure with the G / C genotype of Gly389Arg polymorphism of the b1-adrenoreceptors gene have a lower risk of developing atrial fibrillation (OR=0.14 (0.03–0.61), p=0.0043, co-dominant model of heredity).

The data on a decrease in the risk of atrial fibrillation in patients with heart failure and with the G/C genotype Gly389Arg polymorphism of the b1-adrenoreceptors gene are also confirmed in the overdominant (OR=0.15 (0.03–0.64), p=0.0012), as well as in the dominant (OR=0.23 (0.08-0.69), p=0.0029) and the log-additive (OR=0.40 (0.17-0.94), p=0.019) models.

Findings. The results allow us to conclude that congenital genetic differences in the pathways of b-adrenoreception can be associated with the development of atrial fibrillation in patients with heart failure

Author Biographies

Sergiy Pyvovar, Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039

PhD, Senior Researcher

Department of Clinical Pharmacology and Pharmacogenetics non Infective Diseases

Iurii Rudyk, Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039

MD, Senior Researcher, Head of Department

Department of Clinical Pharmacology and Pharmacogenetics non Infective Diseases

Tatyana Lozyk, Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039

Researcher

Department of Clinical Pharmacology and Pharmacogenetics non Infective Diseases

Valentina Galchinskaya, Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039

PhD, Senior Researcher, Head of Laboratory

Laboratory of Immuno-Biochemical and Molecular-Genetics Researches

Tatiana Bondar, Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039

PhD, Senior Researcher

Laboratory of Biochemical and Immunoenzyme Methods of Research with Morphology

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Published

2019-12-11

How to Cite

Pyvovar, S., Rudyk, I., Lozyk, T., Galchinskaya, V., & Bondar, T. (2019). The polymorphisms of beta-adrenergic receptors genes and a risk of atrial fibrillation development in patients with a heart failure. ScienceRise: Medical Science, (6 (33), 11–19. https://doi.org/10.15587/2519-4798.2019.183384

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No. 6 (33) (2019)

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Medical Science

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Copyright (c) 2019 Sergiy Pyvovar, Iurii Rudyk, Tatyana Lozyk, Valentina Galchinskaya, Tatiana Bondar

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