Biochemical indicators and course of dermatosis in children with psoriasis depending on the body mass index

Authors

DOI:

https://doi.org/10.15587/2519-4798.2020.221120

Keywords:

Psoriasis, children, psoriasis severity indices PASI, BSA and PGA, biochemical profile indicators, GGT, uric acid, body mass index

Abstract

The aim. To study the effect of increased body weight in children with psoriasis on the indicators of the biochemical profile and the severity of the pathological process.

Materials and methods. The indicators of the biochemical profile were studied in 108 children, namely: the level of total protein, total bilirubin, cholesterol, liver enzymes (ALT, AST, GGT), triglycerides and low density lipoproteins, creatinine, urea, uric acid (UA), depending on the mass index body (BMI). The research materials were statistically processed using parametric analysis methods using the STATISTICA 13.3 software (developed by StatSoft. Inc).

Results. Lipid profile indices both in the group of children with normal BMI and in the group of children with increased BMI are within the reference values. Statistically significant differences were found between the average GGT level in the group of children with increased BMI compared with the indicators in the group of children with normal BMI and indicators in the children of the control group. Also, in children with increased BMI, the average UA level is statistically significant higher than in children of the control group and has direct moderate and significant correlations with indices of the severity of the pathological process. In children with increased BMI, psoriasis severity indices correlate with BMI: PGA (r=0.51, p<0,01) BSA (r=0.48, p<0,01), PASI at the beginning of treatment (r=0.41, p<0,05) and PASI at the end of treatment (r=0.67, p<0.001) and percentage of excess body weight: BSA (r=0.34, p<0,05), PASI at the end of treatment (r=0.67, p<0.001). In children with normal BMI, such correlations were not found

Author Biography

Elvina Murzina, Shupyk National Medical Academy of Postgraduate Education Dorohozhytska str., 9, Kyiv, Ukraine, 04112

PhD, Associate Professor

Department of Dermatovenereology

References

  1. Akcali, C., Buyukcelik, B., Kirtak, N., İnaloz, S. (2014). Clinical and laboratory parameters associated with metabolic syndrome in Turkish patients with psoriasis. Journal of International Medical Research, 42 (2), 386–394. doi: http://doi.org/10.1177/0300060513502891
  2. Farshchian, M., Ansar, A., Sobhan, M. R. (2013). Psoriasis and risk factors of metabolic syndrome: A case-control study. Dermatology & Cosmetic, 4 (1), 10–18.
  3. Jensen, P., Thyssen, J. P., Zachariae, C., Hansen, P. R., Linneberg, A., Skov, L. (2012). Cardiovascular risk factors in subjects with psoriasis: a cross-sectional general population study. International Journal of Dermatology, 52 (6), 681–683. doi: http://doi.org/10.1111/j.1365-4632.2011.05408.x
  4. Solomon, G. (2014). The role of weight loss in the treatment of psoriasis: evidence that psoriasis is a systemic inflammatory disorder linked to metabolic syndrome. British Journal of Dermatology, 170 (3), 492–493. doi: http://doi.org/10.1111/bjd.12877
  5. Zhu, K. J., He, S. M., Zhang, C., Yang, S., Zhang, X. J. (2011). Relationship of the body mass index and childhood psoriasis in a Chinese Han population: A hospital-based study. The Journal of Dermatology, 39 (2), 181–183. doi: http://doi.org/10.1111/j.1346-8138.2011.01281.x
  6. Augustin, M., Radtke, M. A., Glaeske, G., Reich, K., Christophers, E., Schaefer, I., Jacobi, A. (2015). Epidemiology and Comorbidity in Children with Psoriasis and Atopic Eczema. Dermatology, 231 (1), 35–40. doi: http://doi.org/10.1159/000381913
  7. Kim, C. R., Lee, J.-H. (2013). An Observational Study on the Obesity and Metabolic Status of Psoriasis Patients. Annals of Dermatology, 25 (4), 440–444. doi: http://doi.org/10.5021/ad.2013.25.4.440
  8. Badaoui, A., Tounian, P., Mahé, E. (2019). Psoriasis and metabolic and cardiovascular comorbidities in children: A systematic review. Archives de Pédiatrie, 26 (2), 86–94. doi: http://doi.org/10.1016/j.arcped.2018.12.005
  9. Paller, A. S., Mercy, K., Kwasny, M. J., Choon, S. E., Cordoro, K. M., Girolomoni, G. et. al. (2013). Association of Pediatric Psoriasis Severity With Excess and Central Adiposity. JAMA Dermatology, 149 (2), 166–176. doi: http://doi.org/10.1001/jamadermatol.2013.1078
  10. Goldminz, A. M., Buzney, C. D., Kim, N., Au, S.-C., Levine, D. E., Wang, A. C. et. al. (2013). Prevalence of the Metabolic Syndrome in Children with Psoriatic Disease. Pediatric Dermatology, 30 (6), 700–705. doi: http://doi.org/10.1111/pde.12218
  11. Jensen, P., Zachariae, C., Iversen, L., Hansen, P., Skov, L. (2014). Cardiovascular Risk Factors in Children and Adolescents with Psoriasis: A Case-control Study. Acta Dermato Venereologica, 94 (1), 76–78. doi: http://doi.org/10.2340/00015555-1607
  12. Menter, A., Cordoro, K. M., Davis, D. M. R., Kroshinsky, D., Paller, A. S., Armstrong, A. W. et. al. (2020). Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis in pediatric patients. Journal of the American Academy of Dermatology, 82 (1), 161–201. doi: http://doi.org/10.1016/j.jaad.2019.08.049
  13. Osier, E., Wang, A. S., Tollefson, M. M., Cordoro, K. M., Daniels, S. R., Eichenfield, A. et. al. (2017). Pediatric Psoriasis Comorbidity Screening Guidelines. JAMA Dermatology, 153 (7), 698–704. doi: http://doi.org/10.1001/jamadermatol.2017.0499
  14. Murzina, Е. О. (2020). Dependence of indicators of the biochemical profile of children with psoriasis on the severity of the pathological process. Ukrainian Medical Journal, 5 (139), 1–5. doi: http://doi.org/10.32471/umj.1680-3051.139.192013
  15. Obesity and overweight. Fact Sheet (2020). World Health Organization. Available at: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
  16. Pietrzak, A. (2010). Lipid Disturbances in Psoriasis: An Update. BAD, 535–612.
  17. Yin, L., Hu, Y. Y., Guo, J., Tu, J., Yin, Z. Q. (2017). Liver dysfunction of psoriatic patients: low serum total protein and albumin increase hospital stays. Biomedical Research, 28 (13), 5–8.
  18. Becker, L., Tom, W. L., Eshagh, K., Benjamin, L. T., Paller, A. S. (2014). Excess Adiposity Preceding Pediatric Psoriasis. JAMA Dermatology, 150 (5), 573–574. doi: http://doi.org/10.1001/jamadermatol.2014.324
  19. Aksu, F., Caliskan, M., Yilmaz, Y. (2016). Gamma-glutamyltransferase and Markers of Subclinical Atherosclerosis in Patients with Psoriasis Kenan Demircioglu. Arteriosclerosis, Thrombosis, and Vascular Biology, 36, A441
  20. Li, X., Miao, X., Wang, H., Wang, Y., Li, F., Yang, Q. et. al. (2016). Association of Serum Uric Acid Levels in Psoriasis. A Systematic Review and Meta-Analysis. Medicine, 95 (19), e3676. doi: http://doi.org/10.1097/md.0000000000003676
  21. Obmen mochevoi kisloty i patogenez narushenii. Kompendium – lekarstvennye preparaty Podagra: vzgliad v buduschee. Available at: https://compendium.com.ua/tutorials/podagra/obmen-mochevoj-kisloty-i-patogenez-narushenij/

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Published

2020-12-28

How to Cite

Murzina, E. (2020). Biochemical indicators and course of dermatosis in children with psoriasis depending on the body mass index. ScienceRise: Medical Science, (6 (39), 45–49. https://doi.org/10.15587/2519-4798.2020.221120

Issue

No. 6 (39) (2020)

Section

Medical Science

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Copyright (c) 2020 Elvina Murzina

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