The study of heart rhythm variability in patients with primary manifestations of chronic cerebral ischemia

Authors

  • Марина Анатоліївна Тріщинська Shupyk National Medical Academy of Postgraduate Education Dorogozhytska str., 9, Kyiv, Ukraine, 04112, Ukraine https://orcid.org/0000-0002-1022-0635

DOI:

https://doi.org/10.15587/2519-4798.2016.76382

Keywords:

chronic cerebral ischemia, primary manifestations, heart rhythm variability, endothelial dysfunction

Abstract

We carried out the research, aimed at the assessment of the features of vegetative balance state and of the character of interconnection with endothelial function in patients with primary manifestations of chronic cerebral ischemia (CCI).

Material and methods. There were examined 108 persons with primary manifestations of CCI. Patients were divided in two groups depending on presence of neuroimaging changes in brain of probably vascular origin, and patient of 2 group were divided in two subgroups (A and B) according to absence and presence of cerebral atrophy. All patients underwent generally clinical, clinical-neurological, clinical-instrumental and clinical-laboratory examinations. For the study of the heart rhythm variability (HRV) the Holter monitoring of ECG was carried out. The vasomotor function of endothelium was assessed by the content of endothelin-1 (ET-1) and nitrite in blood plasma.

Results and their discussion. In persons of all groups the increase of value of HRV parameters were observed reliably more often than their decrease (р<0,05) that could testify to the higher activity of parasympathetic link of regulation.

The reverse moderate correlation was revealed between SDNN index and ЕТ-1 level (r=-0,352, р=0,018).

The increase of intima-media complex (IMC) thickness was associated with index SDNN (=6,5; V Cramer=0,358, р=0,038) and index SDАNN (=5,85; V Cramer=0,339, р=0,05).

Conclusions. On the background of increase of the general tone of parasympathetic link in persons with primary manifestations of CC, the signs of decrease of brain and vasomotor dysfunction, an increase of activity of ANS sympathetic link was observed

Author Biography

Марина Анатоліївна Тріщинська, Shupyk National Medical Academy of Postgraduate Education Dorogozhytska str., 9, Kyiv, Ukraine, 04112

Candidate of Medical Sciences, Associate Professor

Depatment of neurology № 1

References

  1. Mischenko, T. S., Lapshina, I. A., Mischenko, V. N. (2010). Hronicheskaya ishemiya mozga (kriterii diagnostiki, novyie vozmozhnosti lecheniya). Ukrayinskiy medichniy chasopis, 6 (80), 101–104.
  2. Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D’Agostino, R. B., Gibbons, R. et. al. (2013). 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk. Circulation, 129 (25), S49–S73. doi: 10.1161/01.cir.0000437741.48606.98
  3. Kokubo, Y. (2014). Prevention of Hypertension and Cardiovascular Diseases. Hypertension, 63 (4), 655–660. doi: 10.1161/hypertensionaha.113.00543
  4. Smyishlyaeva, O. M. (2010). Variabelnost ritma serdtsa u bolnyih distsirkulyatornoy entsefalopatiey. Saratovskiy nauchno-meditsinskiy zhurnal, 6 (4), 800–803.
  5. Heart Rate Variability : Standards of Measurement, Physiological Interpretation, and Clinical Use (1996). Circulation, 93 (5), 1043–1065. doi: 10.1161/01.cir.93.5.1043
  6. Zharinov, O. Y., Sorokivskiy, M. S., Chernyaga-Royko, U. P. (2004). Holterivske monItoruvannya elektrokardiogrami: evolyutsiya klinichnogo zastosuvannya, diagnostichni mozhlyvosti, pokazannya. Ukrayinskiy kardIologichniy zhurnal, 1, 122–132.
  7. Kotelnikov, S. A., Nozdrachev, A. D., Odinak, M. M. et. al. (2002). Variabelnost ritma serdtsa: predstavleniya o mehanizmah. Fiziologiya cheloveka, 28 (1), 130–143.
  8. Tatarenko, S. A., Beyn, B. N. (2009). Vegetativnaya disregulyatsiya v gruppah bolnyih opuholyu golovnogo mozga v sravnenii s distsirkulyatornoy entsefalopatiey. Byulleten sibirskoy meditsinyi, 1 (2), 83–87.
  9. Aird, W. C. (2007). Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms. Circulation Research, 100 (2), 158–173. doi: 110.1161/01.res.0000255691.76142.4a
  10. Rajendran, P., Rengarajan, T., Thangavel, J., Nishigaki, Y., Sakthisekaran, D., Sethi, G., Nishigaki, I. (2013). The Vascular Endothelium and Human Diseases. International Journal of Biological Sciences, 9 (10), 1057–1069. doi: 10.7150/ijbs.7502
  11. Nechesova, T. A., Liventseva, M. M., Korobko, I. Yu. et. al. (2013). Metod profilaktiki essentsialnoy arterialnoy gipertenzii, osnovannyiy na ranney diagnostike i kompleksnom lechenii stress-indutsirovannoy gipertenzii. Minsk, 7.
  12. Makarov, L. M., Komolyatova, V. N.; Ardashev, A. V. (Ed.) (2009). Holterovskoe monitorirovanie v obsledovanii bolnyih s narusheniyami ritma serdtsa. Klinicheskaya aritmologiya. Moscow: Medpraktika, 119–156.
  13. Bobrov, V. O., Zharinov, O. Y., Kuts, V. O. et. al. (2004). Ambolatorne monitoruvannya EKG. Kyiv, 67.
  14. Crawford, M. H., Bernstein, S. J., Deedwania, P. C., DiMarco, J. P., Ferrick, K. J., Garson, A. et. al. (1999). ACC/AHA Guidelines for Ambulatory Electrocardiography: Executive Summary and Recommendations : A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the Guidelines for Ambulatory Electrocardiography) Developed in Collaboration With the North American Society for Pacing and Electrophysiology. Circulation, 100 (8), 886–893. doi: 10.1161/01.cir.100.8.886
  15. Stein, P. K., Kleiger, R. E., Rottman, J. N. (1997). Differing Effects of Age on Heart Rate Variability in Men and Women. The American Journal of Cardiology, 80 (3), 302–305. doi: 10.1016/s0002-9149(97)00350-0
  16. Umetani, K., Singer, D. H., McCraty, R., Atkinson, M. (1998). Twenty-Four Hour Time Domain Heart Rate Variability and Heart Rate: Relations to Age and Gender Over Nine Decades. Journal of the American College of Cardiology, 31 (3), 593–601. doi: 10.1016/s0735-1097(97)00554-8

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Published

2016-08-31

How to Cite

Тріщинська, М. А. (2016). The study of heart rhythm variability in patients with primary manifestations of chronic cerebral ischemia. ScienceRise: Medical Science, (8 (4), 59–63. https://doi.org/10.15587/2519-4798.2016.76382

Issue

No. 8 (4) (2016)

Section

Medical Science

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Copyright (c) 2016 Марина Анатоліївна Тріщинська

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