The study of fatty-acid spectrum of blood serum in patients with aspirin associated polypous rhinosinusitis

Authors

DOI:

https://doi.org/10.15587/2519-4798.2016.76459

Keywords:

polypous rhinosinusitis, intolerance to aspirin, arachidonic acid, unsaturated, saturated fatty acids

Abstract

Aim of research – to study the composition of the main representatives of polyunsaturated and saturated fatty acids in blood serum of patients with chronic polypous rhinosinusitis, associated with intolerance to acetylsalicinic acid.

Materials and methods. The fatty-acid composition of blood serum was determined by the method of capillary gas-liquid chromatography in 20 ill and 7 healthy donors.

Results: The change of composition of unsaturated fatty acids is in increase of arachidonic acid level, decrease of the content of its main predecessors – linoleic and eicosapentaenoic acids, normal level of intermediate products:α – and γ – linoleic acid and increase of the level of oleic acid. The content of the main saturated fatty acids: palmitic, stearic, arachidic ones is increased. The fatty acids imbalance testifies to the proinflammatory directionality of lipid metabolism.

Conclusions:

1. The increase of the level of polyunsaturated (arachdonic and oleic acids) leads to the compensatory decrease of the level of the main predecessors of arachinonic – linoleic and eicosapentaenoic acids. This mechanism allows keep the intermediate products of synthesis of arachidonic acid - α – and γ – linoleic acids at the normal level.

2. The content of saturated fatty acids with alternative biological effects is increased in blood serum as a compensatory mechanism of leveling of biological effects of polyunsaturated fatty acids and their metabolites,.

3. The revealed imbalance of fatty acids testifies to the proinflammatory directionality of the lipid metabolism.

4. The changes of fatty-acid spectrum of lipids in the blood serum prove the hypothesis of “genetic block COG1” as the main pathogenetic link of aspirin associated polypous rhinosinusitis

Author Biography

Іванна Василівна Кошель, Ivano-Frankivsk National Medical University Halytska str., 2, Ivano-Frankivsk, Ukraine, 76018

Assistant

Department otolaryngology & head and neck surgery

References

  1. Zhuravl'ov, A. S., Lupyr, A. V., Mishhenko, O. M., Kocjura, L. P. (2014). Kliniko-epidemiologichni osoblyvosti obstezhennja hvoryh na polipoznyj rynosynusyt. ZhVNGH, 3, 65–66.
  2. Fokkens, W., Lund, V., Mullol, J. (2012). EPOS 2012 European position paper on rhinosinusitis and nasal polyps 2012. Rhinol, 50 (1), 1–12. doi: 10.4193/Rhino50E2
  3. Batra, P. S., Tong, L., Citardi, M. J. (2013). Analysis of comorbidities and objective parameters in refractory chronic rhinosinusitis. The Laryngoscope, 123, S1–S11. doi: 10.1002/lary.24418
  4. Stevens, W., Buchheit, K., Cahill, K. N. (2015). Aspirin-Exacerbated Diseases: Advances in Asthma with Nasal Polyposis, Urticaria, Angioedema, and Anaphylaxis. Current Allergy and Asthma Reports, 15 (12). doi: 10.1007/s11882-015-0569-2
  5. Erdogan, T., Karakaya, G., Kalyoncu, A. F. (2015). Comorbid diseases in aspirin-exacerbated respiratory disease, and asthma. Allergologia et Immunopathologia, 43 (5), 442–448. doi: 10.1016/j.aller.2014.07.008
  6. Wojtczak, A., Skrętkowicz, J. (2015). Hypersensitivity to acetylsalicylic acid. Wiad Lek, 68 (2), 193–197.
  7. Krouse, H. J., Krouse, J. H. (2015). Samter's Triad to Aspirin-Exacerbated Respiratory Disease: Historical Perspective and Current Clinical Practice. ORL Head Neck Nurs, 33 (4), 14–18.
  8. Ledford, D. K., Lockey, R. F. (2016). Aspirin or Nonsteroidal Anti-inflammatory Drug-Exacerbated Chronic Rhinosinusitis. The Journal of Allergy and Clinical Immunology: In Practice, 4 (4), 590–598. doi: 10.1016/j.jaip.2016.04.011
  9. Nabavi, M., Esmaeilzadeh, H., Arshi, S., Bemanian, M. H., Fallahpour, M., Bahrami, A. et. al. (2014). Aspirin hypersensitivity in patients with chronic rhinosinusitis and nasal polyposis: Frequency and contributing factors. American Journal of Rhinology and Allergy, 28 (3), 239–243. doi: 10.2500/ajra.2014.28.4034
  10. Rondón, C., Dávila, I., Navarro Pulido, A. M. et. al. (2015). Clinical Management and Use of Health Care Resources in the Treatment of Nasal Polyposis in Spanish Allergy Centers: The POLAR Study. J Investig Allergol Clin Immunol, 25 (4), 276–282.
  11. Koshel, I. V., Dudij, P. F., Ryzhyk, V. M. et. al. (2010). Aspіrinova trіada: novі poglyadi na etіopatogenez і dіagnostiku [Aspirin triad: new views on etiopathogenesis and diagnostics]. Ultrasonic perenatal diagnostics, 30, 153–154.
  12. Simon, R. A., Dazy, K. M., Waldram, J. D. (2015). Aspirin-exacerbated respiratory disease: characteristics and management strategies. Expert Review of Clinical Immunology, 11 (7), 805–817. doi: 10.1586/1744666x.2015.1039940
  13. Makowska, J., Lewandowska-Polak, A., Kowalski, M. L. (2015). Hypersensitivity to Aspirin and other NSAIDs: Diagnostic Approach in Patients with Chronic Rhinosinusitis. Current Allergy and Asthma Reports, 15 (8). doi: 10.1007/s11882-015-0552-y
  14. Popovych, V. I., Koval'chuk, L. Je., Erstenjuk, G. M., Ryzhyk, V. M., Koshel', I. V. (2009). Aspirynova triada, jak metabolichne zahvorjuvannja. ZhVNGH, 2, 76–86.
  15. Koshel', I. V., Bagrij, M. M., Zabolotna, D. D. (2014). Riven' ekspresii' konstytutyvnoi' cyklooksygenazy v tkanynah porozhnyny nosa u pacijentiv z riznym typom nazal'nogo polipozu. Rynologija, 3, 21–30.
  16. Koshel', I. V., Ostrovs'kyj, M. M., Varunkiv, V. I., Popovych, V. I. (2016). Novi mozhlyvosti v diagnostyci aspirynovoi' giperchutlyvosti u hvoryh na bronhial'nu astmu, pojednanu z nazal'nym polipozom. Ukrai'ns'kyj pul'monologichnyj zhurnal, 1, 29–32.
  17. Popovych, V. I., Ostrovs'kyj, M. M., Varunkiv, O. I., Koshel', I. V. (2012). Pat № 100487 Ukrai'ny. Sposib diagnostyky aspirynovoi' giperchutlyvosti u hvoryh na bronhial'nu astmu shljahom vyznachennja funkcional'nogo stanu metabolizmu arahidonovoi' kysloty. MPK (2012.01) A61V 10/00 G01N 33/50 (2006.01). a201200631; zajavl. 20.01.2012; opubl. 25.12.2012, Bjul. № 24.
  18. Kates, M. (1986). Techniques of lipidology: isolation, analysis and identification of lipids. Amsterdam: Elsevier Science Publishers, 451.
  19. Lapach, S. N., Chubenko, A. V., Babich, P. N. (2000). Statisticheskie metody v mediko-biologicheskih issledovanijah s ispol'zovaniem Exel. Kyiv: Morion, 320.
  20. Sergeeva, M. G., Varfolomeeva, A. T. (2006). Kaskad arahidonovoj kisloty. Moscow: Narodnoe obrazovanie, 256.

Downloads

Published

2016-08-31

How to Cite

Кошель, І. В. (2016). The study of fatty-acid spectrum of blood serum in patients with aspirin associated polypous rhinosinusitis. ScienceRise: Medical Science, (8 (4), 26–30. https://doi.org/10.15587/2519-4798.2016.76459

Issue

No. 8 (4) (2016)

Section

Medical Science

License

Copyright (c) 2016 Іванна Василівна Кошель

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.

Authors, who are published in this journal, agree to the following conditions:

1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.

 2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.