TY - JOUR AU - Ovcharenko, Irina AU - Shevchenko, Olga PY - 2017/09/30 Y2 - 2024/03/28 TI - Study of fibrosis factors in patients with firstly diagnosed multidrug-resistant pulmonary tuberculosis JF - ScienceRise: Medical Science JA - SR:MS VL - 0 IS - 9 (17) SE - DO - 10.15587/2519-4798.2017.111009 UR - https://journals.uran.ua/sr_med/article/view/111009 SP - 16-21 AB - <p><strong>Aim</strong><strong>.</strong> To study the levels of tissue factors of fibrosis and markers of destruction of the pulmonary tissue in patients with firstly diagnosed multidrug-resistant pulmonary tuberculosis.</p><p><strong>Materials and methods</strong><strong>.</strong> There were examined 48 patients with firstly diagnosed multidrug-resistant pulmonary tuberculosis, divided in groups depending on treatment results, with studied levels of general oxyproline, free and protein-bound oxyproline and also aldosterone, matrix metalloproteinase-9 and tissue inhibitor of metalloprotainase-1 at the beginning of the treatment. Pearson’s χ2 and Fisher methods, Kruskel-Wallis criteria, Spearman methods were used.</p><p><strong>Results</strong><strong>.</strong> The group of patients, who finished their treatment successfully, demonstrated the mean values of oxyproline and MP-9, the highest levels of aldosterone and TIMP-1 compared with other groups of patients. Patients, who died before the finish of the main course of chemotherapy, had demonstrated the highest levels of bound oxyproline and MP-9, and also a bit lower levels of free oxyproline and TIMP-1 compared with the group of effectively treated ones. The least levels of all studied parameters were observed in the group of unsuccessfully treated patients.</p><p><strong>Conclusion</strong><strong>.</strong> The processes of decay of the pulmonary tissue prevailed over the reparation ones in the groups of the non-effective treatment that is indicated by an imbalance of free and protein-bound oxyproline and MP-9/TIMP-1 ratio. The exhaustion of compensatory mechanisms may be indicated by the lower level of aldosterone in the groups of the non-effective treatment and its reverse correlation with the prevalence of tuberculosis process and intoxication signs</p> ER -