Substantiation of the composition of surface-active substances in development of a cream with silver citrate

Authors

DOI:

https://doi.org/10.15587/2519-4852.2017.119890

Keywords:

emulsion system, surfactants, cream, silver citrate, stability

Abstract

Pharmaceutical emulsions are now given increasing attention because they are widely used in medical practice. This became possible due to a qualitatively new level of scientific research and achievements in the field of emulsion systems creation, as well as expansion of assortment of auxiliary substances and use of new modern equipment. Emulsions are heterogeneous disperse systems that are potentially unstable. Therefore, the issue of stabilizing of emulsion systems is the main problem in area of emulsions technology.

Aim. The aim of the experiment was to study structural and mechanical properties of concentrated emulsion systems, depending on the total concentration of surfactants, as well as investigation of colloidal and thermal stability of samples for substantiation of the composition of surfactants in the development of a cream with silver citrate.

Methods. Pharmaco-technological methods of research were conducted in accordance with the requirements of the State Pharmacopoeia of Ukraine.

Research results. Colloidal and thermal stability of the samples of emulsion cream with silver citrate was investigated. It has been established that the use of emulsifiers in concentrations of 4 % and 6 % does not provide physical stability. A dispersion analysis of the heterogeneous systems was carried out, which has shown that the samples obtained by using of the emulsifiers combination are homogeneous in size of particles of oil phase, which do not exceed 10 microns. The behavior of samples of the emulsion cream with silver citrate during and after mechanical destruction is investigated. The results guarantee stability of the system under the influence of mechanical processing during industrial production and use.

Conclusion. As a result of the experiment, the use of the combination of surface-active substances: emulsifier № 1 and cetostearyl alcohol of 8-10 % was used to stabilize the emulsion system with silver citrate

Author Biographies

Zhanna Polova, Bohomolets National Medical University Tarasa Shevchenka blvd., 13, Kyiv, Ukraine, 01601

PhD, Associate Professor

Department of Pharmaceutical and Industrial Technology of Medicines

Ievgenii Gladukh, National University of Pharmacy Pushkinska str., 53, Kharkov, Ukraine, 61002

Doctor of Pharmaceutical Sciences, Professor, Head of Department

Department of Industrial Pharmacy

Halyna Kukhtenko, National University of Pharmacy Pushkinska str., 53, Kharkov, Ukraine, 61002

PhD, Associate Professor

Department of Industrial Pharmacy

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Published

2017-12-31

How to Cite

Polova, Z., Gladukh, I., & Kukhtenko, H. (2017). Substantiation of the composition of surface-active substances in development of a cream with silver citrate. ScienceRise: Pharmaceutical Science, (6 (10), 44–51. https://doi.org/10.15587/2519-4852.2017.119890

Issue

No. 6 (10) (2017)

Section

Pharmaceutical Science

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Copyright (c) 2018 Zhanna Polova, Ievgenii Gladukh, Halyna Kukhtenko

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