Macroscopic and microscopic analysis of Alfredia nivea KAR. & KIR herb

Authors

DOI:

https://doi.org/10.15587/2519-4852.2023.274766

Keywords:

Alfredia nivea, medicinal plant raw material, morphological and anatomical signs, standardization

Abstract

Kazakhstan flora is rich in promising little-studied plants that are used in folk medicine, but additional deep research is required for their introduction into medical practice with the help of modern scientific techniques. An interesting object for introduction into the official medical and pharmaceutical practice is the Alfredia Nivea Kar. & Kir, family Asteraceae, whose extracts have a neurotropic effect.

The aim. Regarding mentioned above, in order to create new medicines based on the grass of the Alfredia nivea, it is necessary to develop methods of its macro and microscopic identification.

Materials and methods. Macro- and microscopic studies of the grass of Alfredia nivea were carried out in accordance with the methodology of SPhU 2.8.23 "Microscopic examination of medicinal vegetable raw materials". Macroscopic studies were performed using magnifying glass and binocular microscope MBS-9, microscopic-using MS Microscopes 10 (eyepiece X5, X10, X15, lenses x10, x40), micromed XS-4130 (WF15X, Opera, lens X40/0, 65, x10/0,25) with microphoto addon (China).

Results. The morphological and anatomical features of the Alfredia nivea grass. Diagnostic features of the structure of stems, leaves and flowers of this species were revealed.

Conclusions. The macroscopic and anatomical identification parameters of the grass of the Alfredia of Snow. The study of the morphological and anatomical features of the stems, leaves and flowers of Alfredia nivea, considering the requirements of European pharmacopoeia. Diagnostic features of the structure of stems, leaves and flowers of the species were found, which were used as key quality indicators for standardization and identification of raw materials

Author Biographies

Almat Rustemkulov, S. D. Asfendiyarov Kazakh National Medical University

PhD Student

Tetiana Gontova, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Pharmacognosy

Balzhan Makhatova, S. D. Asfendiyarov Kazakh National Medical University

PhD, Associate Professor

Department of Engineering Disciplines and Good Practices

Aisana Rustemkulova, S. D. Asfendiyarov Kazakh National Medical University

PhD Student

Nadezhda Gemedzhieva, Institute of Botany and Phytointroduction

Doctor of Biological Sciences, Head of Laboratory

Laboratory of Plant Resources

Aizhamal Shormanova, Institute of Botany and Phytointroduction

PhD, Leading Specialist

Laboratory of Flora of Higher Plants

Galyna Starchenko, Ivano-Frankivsk National Medical University

PhD, Associate Professor

Department of Pharmaceutical Management, Drug Technology and Pharmacognosy

Ain Raal, University of Tartu

PhD, Professor

Institute of Pharmacy

Ubaidilla Datkhaev, S. D. Asfendiyarov Kazakh National Medical University

Doctor of Pharmaceutical Sciences, Professor, Vice-Rector for Corporate Development

Oleh Koshovyi, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Pharmacognosy

References

  1. Zhumashova, G., Kukula-Koch, W., Koch, W., Baj, T., Sayakova, G., Shukirbekova, A., Głowniak, K., Sakipova, Z. (2019). Phytochemical and Antioxidant Studies on a Rare Rheum cordatum Losinsk. Species from Kazakhstan. Oxidative Medicine and Cellular Longevity, 2019, 1–9. doi: https://doi.org/10.1155/2019/5465463
  2. Sayakova, G., Boshkayeva, A., Ibadullayeva, G., Khamitova, A., Begimova, G. (2022). Actual prospects of using some types of larch growing in Kazakhstan in medicine. Journal of Medicine and Life, 15 (8), 1038–1046. doi: https://doi.org/10.25122/jml-2021-0373
  3. Kiyekbayeva, L. N., Datkhayev, U. M., Derbisbekova, U. B., Akhtaeva, N. C., Litvinenko, Y. A. (2017). Phytochemical investigation and technology production of alkaloids in the Kazakh endemic plant Echinops albicaulis Kar.Et Kir. (Asteraceae). International Journal of Green Pharmacy, 11 (2), S312–S319.
  4. Alfredia Cassini in F. Cuvier, Dict. Sci. Nat. 1(Suppl.): 115. 1816. Available at: http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200023066
  5. Alfredia nivea Karelin & Kirilov, Bull. Soc. Imp. Naturalistes Moscou. 15: 395. 1842. Available at: http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200023068
  6. Haining, Q. et al. (Eds.) (2010). China Checklist of Higher Plants, In the Biodiversity Committee of Chinese Academy of Sciences ed. Catalogue of Life China: 2010 Annual Checklist China. Species 2000 China Node. Beijing.
  7. Novozhilova, E. V., Boyko, E. V. (2019). Morphological and anatomical structure of the cypselas of Alfredia (Asteraceae: Cardueae). Turczaninowia, 22 (4), 42–56. doi: https://doi.org/10.14258/turczaninowia.22.4.6
  8. Korneyev, S. V. (2013). Revision of species of the genus tephritis latreille 1804 (Diptera: Tephritidae) with entire apical spot. Zootaxa, 3620 (1), 67–88. doi: https://doi.org/10.11646/zootaxa.3620.1.3
  9. Shilova, I. V., Kuvacheva, N. V., Kolmakova, A. A., Losev, V. N., Minakova, M. Yu. (2021). Biologically Active Substances in the Aqueous Fraction of Alfredia cernua (L.) Cass. Extract Possessing Antiamnesic Properties. Pharmaceutical Chemistry Journal, 54 (12), 1239–1242. doi: https://doi.org/10.1007/s11094-021-02349-5
  10. Shilova, I. V., Baranovskaja, N. V., Mustafin, R. N., Suslov, N. I. (20190. Features of the composition macro ele-ments and trace elements of the extract of alfredia cernua (L.) Cass., Possessing psycho-tropic effect. Khimiya Rastitel'nogo Syr'ya, 4, 191–198.
  11. Shilova, I. V., Kukina, T. P., Suslov, N. I., Sal’nikova, O. I., Mustafin, R. N. (2014). Studies of the Lipophilic Components of a Dense Extract of the Herb Alfredia Cernua and its Nootropic Properties. Pharmaceutical Chemistry Journal, 48 (3), 181–185. doi: https://doi.org/10.1007/s11094-014-1074-y
  12. Mustafin, R. N., Suslov, N. I., Shilova, I. V., Kuvacheva, N. V. (2010). Influence of Alfredia cernua extracts on the behavior, memory, and physical work capacity of experimental animals. Eksperimental'naya i Klinicheskaya Farmakologiya, 73 (1), 16–19.
  13. Mustafin, R. N., Shilova, I. V., Suslov, N. I., Kuvacheva, N. V., Amelchenko, V. P. (2011). Nootropic Activity of Extracts from Wild and Cultivated Alfredia Cernua. Bulletin of Experimental Biology and Medicine, 150 (3), 333–335. doi: https://doi.org/10.1007/s10517-011-1135-0
  14. Shylova, Y. V., Suslov, N. Y. (2019). Neiroprotektornaia aktyvnost byolohychesky aktyvnыkh veshchestv Alfredia nivea. Rol metabolomyky v sovershenstvovanyy byotekhnolohycheskykh sredstv proyzvodstva, 223–227.
  15. Kuvacheva, N. V., Shilova, I. V. (2011). Standartizatciia travy alfredii ponikshei. Voprosy biologicheskoi, meditcinskoi i farmatcevticheskoi khimii, 5, 9–12.
  16. Dobrochaeva, D. N., Kotov, M. I., Prokudin, Y. N., Barbarich, A. I. (1999). Opredelitel vysshikh rastenii Ukrainy. Kyiv Science Dumka.
  17. Zabolotnyi, O., Koshevoi, M. (2020). An effective method of bulk materials moisture measurement using capacitive sensors. Journal of Stored Products Research, 89, 101733. doi: https://doi.org/10.1016/j.jspr.2020.101733
  18. Zabolotnyi, O., Zabolotnyi, V., Koshevoy, N. (2021). Oil Products Moisture Measurement Using Adaptive Capacitive Instrument Measuring Transducers. Lecture Notes in Networks and Systemsthis. Cham: Springer, 81–91. doi: https://doi.org/10.1007/978-3-030-66717-7_7
  19. Koshevoi, O. N. (2011). Amino-acid and monosaccharide compositions of Salvia officinalis leaves. Chemistry of Natural Compounds, 47 (3), 492–493. doi: https://doi.org/10.1007/s10600-011-9976-3
  20. State Pharmacopoeia of Ukraine. Vol. 1 (2015). Kharkiv: SO «Ukrainian Scientific Pharmacopoeial Center of Drugs Quality», 1128.
  21. Shanaida, M., Hudz, N., Korzeniowska, K., Wieczorek, P. P. (2018). Antioxidant activity of essential oils obtained from aerial part of some Lamiaceae species. International Journal of Green Pharmacy, 12 (3), 200–204.
  22. Koshovyi, O., Granica, S., Piwowarski, J. P., Stremoukhov, O., Kostenko, Y., Kravchenko, G. et al. (2021). Highbush Blueberry (Vaccinium corymbosum L.) Leaves Extract and Its Modified Arginine Preparation for the Management of Metabolic Syndrome – Chemical Analysis and Bioactivity in Rat Model. Nutrients, 13 (8), 2870. doi: https://doi.org/10.3390/nu13082870
  23. Vlasova, I., Gontova, T., Grytsyk, L., Zhumashova, G., Sayakova, G., Boshkayeva, A. et al. (2022). Determination of standardization parameters of Oxycoccus macrocarpus (Ait.) Pursh and Oxycoccus palustris Pers. Leaves. ScienceRise: Pharmaceutical Science, 3 (37), 48–57. doi: https://doi.org/10.15587/2519-4852.2022.260352
  24. Kiyekbayeva, L. N., Akhtaeva, N. Z., Datkhayev, U. M., Omarkhan, A. B., Litvinenko, Y. A., Tynybekov, B. M. et al. (2017). Pharmacognosy signs of aerial parts medicinal plant echinops albicaulis kar.Et kir. Asian Journal of Pharmaceutical and Clinical Research, 10 (6), 346–348. doi: https://doi.org/10.22159/ajpcr.2017.v10i6.18037
  25. Krivoruchko, E., Markin, A., Samoilova, V. A., Ilina, T., Koshovyi, O. (2018). Research in the chemical composition of the bark of Sorbus aucuparia. Ceska a Slovenska Farmacie, 67 (3), 113–115.
  26. Chaika, N., Koshovyi, O., Ain, R., Kireyev, I., Zupanets, A., Odyntsova, V. (2020). Phytochemical profile and pharmacological activity of the dry extract from Arctostaphylos uva-ursi leaves modified with phenylalanine. ScienceRise: Pharmaceutical Science, 6 (28), 74–84. doi: https://doi.org/10.15587/2519-4852.2020.222511
  27. Schweingruber, F. H., Kucerova, A., Adamec, L., Dolezal, J. (2020). Anatomic Atlas of Aquatic and Wetland Plant Stems. Cham: Springer, 486. doi: https://doi.org/10.1007/978-3-030-33420-8

Downloads

Published

2023-02-28

How to Cite

Rustemkulov, A., Gontova, T., Makhatova, B., Rustemkulova, A., Gemedzhieva, N., Shormanova, A., Starchenko, G., Raal, A., Datkhaev, U., & Koshovyi, O. (2023). Macroscopic and microscopic analysis of Alfredia nivea KAR. & KIR herb. ScienceRise: Pharmaceutical Science, (1(41), 41–49. https://doi.org/10.15587/2519-4852.2023.274766

Issue

Section

Pharmaceutical Science