The ointment containing Ag@Fe3O4 for removal and treatment of skin neoplasms

Authors

DOI:

https://doi.org/10.15587/2519-4852.2016.72550

Keywords:

nanoparticles, magnetocontrollable composite system, silver shell, magnetite ointment, cryoscopy

Abstract

Aim. Priorities for improving the thermal conductivity values and the external controllability of the process of cryosurgical intervention have determined. The aim of this work is creation of soft dosage forms with a highly heat-conductive magnetic carrier of the multifunctional action for removal and treatment of skin neoplasms.

Methods. At the initial stage the required parameters and properties of the magnetic component introduced into the composition of magnetocontrollable ointments have been determined. The screening of the antimicrobial activity in terms of the impact of the composite on strains of microorganisms and fungi has been carried out. The magnetite ointments have been tested by the cryodestruction method of removal and treatment of skin neoplasms. For this purpose a special portable apparatus CRY-AC (Brymill) and a contact cryoprobe with nozzles are used.

Results. Based on the results of the research of the magnetic properties of the composite nanoparticles the sample has been selected, it has a high value of saturation specific magnetization σ = 62.5 еmu/g, the nanoparticle size (23 nm) has been determined. The presence of silver on the surface of magnetic nanoparticles makes a significant additional contribution to the thermal conductivity of the composite (the thermal conductivity coefficient of magnetite χ is ~ 5.3 W/(m × K), silver is ~ 420 W/(m × K)), being one of the valuable properties for using it in cryosurgery.

The composition of magnetocontrollable ointments I and II for cryodestruction and post-operative treatment of skin neoplasms has been developed and improved by the main magnetic indicators.

Conclusions. To order to use ointments with a magnetic filler in cryosurgery the magnetic carrier of the "core-shell" type – Ag@Fe3O4 with the islet silver coating has been synthesized and tested.

The advantages of the magnetite ointments with silver in cryointervention and postoperative treatment of skin neoplasms have been found. The use of ointment I has contributed to increase of the analgesic effect by 28 %, and decrease of the cryosurgery duration by 50 %. For the subsequent treatment and healing of wounds after surgical procedures ointment II is used, it improves the post-operative results on an average by 50 %

Author Biographies

Yevgen Levitin, National University of Pharmacy Pushkinska str., 53, Kharkiv, Ukraine, 61002

Professor, Doctor of Pharmacy, Head of Department

Department of Inorganic Chemistry

Tatyana Chan, National University of Pharmacy Pushkinska str., 53, Kharkiv, Ukraine, 61002

Assistant

Department of Inorganic Chemistry

Oleg Kryskiv, National University of Pharmacy Pushkinska str., 53, Kharkiv, Ukraine, 61002

Associate Professor, PhD of Pharmacy

Department of Inorganic Chemistry

Alla Alla Bilovol, Kharkiv National Medical University Nauky ave., 4, Kharkiv, Ukraine, 61022

Professor, MD, Head of Department

Department of Dermatology, Venereology and Medical Cosmetology

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Published

2016-07-01

How to Cite

Levitin, Y., Chan, T., Kryskiv, O., & Bilovol, A. A. (2016). The ointment containing Ag@Fe3O4 for removal and treatment of skin neoplasms. ScienceRise: Pharmaceutical Science, (1 (1), 29–34. https://doi.org/10.15587/2519-4852.2016.72550

Issue

No. 1 (1) (2016)

Section

Pharmaceutical Science

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Copyright (c) 2016 Yevgen Levitin, Tatyana Chan, Oleg Kryskiv, Alla Alla Bilovol

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