Study of the degradation behavior of enisamium iodide, tilorone dihydrochloride, morpholinium thiazotate in the soil by the GC-FID method

Mon, 18 Mar 2024 00:00:00 +0200

The aim. To investigate the behavior in soil of enisamium iodide, tilorone dihydrochloride, morpholinium thiazotate, and the suitability of the previously developed GC-FID methodology.

Materials and methods. The determination of the Enisamium iodide, Tilorone dihydrochloride, Morpholinium thiazotate in soil gas chromatography with a flame ionization detector using the Rxi-5 ms (30 m long, 0.25 mm outer diameter and 0.25 μm liquid stationary phase thickness).

Results. An analysis of the determination of enisamium iodide, tilorone dihydrochloride, and morpholinium thiazotate in soil was conducted. The degradation time of pharmaceuticals in aerobic soil was investigated. The research findings indicate that microbial activity, soil oxygen status, soil type, and compound characteristics influence the degradation of the selected pharmaceuticals in soil.

Conclusions. All methods were accurate and reliable. The previously developed GC-FID methodology by us is suitable for determining enisamium iodide, tilorone dihydrochloride, and morpholinium thiazotate in soil, provided necessary analysis conditions are met. Under aerobic conditions, the rate of dispersion of the selected pharmaceuticals followed the following decreasing order in soil: Enisamium iodide > Tilorone dihydrochloride > Morpholinium thiazotate

ScienceRise: Pharmaceutical Science

Study of the degradation behavior of enisamium iodide, tilorone dihydrochloride, morpholinium thiazotate in the soil by the GC-FID method