DOI: https://doi.org/10.26641/2307-5279.21.1.2017.150085

Alternative treatment scheme of seminoma for carboplatin, etoposide and bleomycin (CEB)

A.V. Sakalo

Abstract


Testicular germ cell tumors are highly sensitive to the chemotherapy, the standard treatment for seminoma stages II–III is 3PEB/4PE, treatment is associated with acute and delayed toxicity. Results of treatment of 17 patients under the scheme CEB (carboplatin AUC=5, etoposide 100 mg/m2in 1–5 days and bleomycin 30 mg on day 2).

3 years OS and DFS after 4CEBis 94,1% and 88,2% respectively, with less toxicity (associated with cisplatin to carboplatin replacement and bleomycin dose reduction to 30 mg). Preliminary results of the treatment with scheme 4CEB seminoma stage II–III can be considered as an alternative to the standard scheme.

Keywords


testicular tumors; chemotherapy; treatment

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