DOI: https://doi.org/10.26641/2307-5279.23.3.2019.178767

Comparative characteristics of morphological changes of the kidneys in modeling in rats pyelonephritis and concomitant diabetes mellitus type I and II

S.O. Borisov, F.I. Kostev, O.V. Borisov, O.V. Artyomov

Abstract


Concomitant diabetes mellitus greatly complicates the course of acute pyelonephritis, significantly affects the prognosis of the disease, and in–depth study of the pathogenetic features of these pathological conditions is an important task, as compared to the characteristics of structural changes in kidney tissues when simulating pyelonephritis in rats on the background of concomitant diabetes. In rats with acute pyelonephritis on the background of diabetes mellitus, pronounced structural abnormalities occurred in the cork layer of the kidney parenchyma with morphological manifestations of acute infectious inflammation and a tendency to form massive, confluent lesions, exciting and the medulla. The study of changes in kidney tissues when modeling acute pyelonephritis on the background of diabetes mellitus type I and II revealed pronounced structural abnormalities in the pith and medullary layers of the kidneys with morphological manifestations of early apoptosis processes. It is likely that the accompanying type I diabetes.

Keywords


acute pyelonephritis; oxidative stress; diabetes mellitus; pathogenesis; detoxification; morphological manifestations

References


Борисов И.А. Пиелонефрит. Нефрология / под ред. Е. В. Тареевой. М.: Медицина, 2000. С. 383–399.

Ю. И. Афанасьев, Н. А. Юрина, Е. Ф. Котовский и др. Гистология, эмбриология, цитология: учебник. 2012. 800 с.

Кюнель В. Цветной атлас по цитологии, гистологии и микроскопической анатомии. М.: АСТ, 2007. 533 с.

Саркисов Д.С., Перов Д.С. Микроскопическая техника. М.: Медицина,1996. 544 с.

Brenner B.M. Kidney development. New York, 1996. P.635–695.

Hasslacher, Similar Ch. Risk of nephropathy in patients with type 1 and type П diabetes mellitus. Nephrology. Dialysis. Transplantation. 1989. Vol. 4. P. 859–863.

Ziydeh F. Significance of tubulointerstitial changes in diabetic renal disease. Kidney International Reports. 1996. Vol. 49. P. 10–13.

Мухин Н.А., Шестакова М.В. Диабетическая нефропатия. Нефрология. Руководство для врачей. М.: Медицина, 2000. С. 448–454.

Шестакова М.В. Диабетическая нефропатия: механизмы развития, клиника, диагностика, лечение. М, 2003. 68 с.

Bucala R., Makita Z., Koschinsky T. et al. Lipid advanced glycosylation: pathway for lipid oxidation in vivo. Proc. Nati. Acad. Sci. USA. 1993. Vol. 90. P. 6434–6438.

Дедов И.И., Балаболкин М.И., Мамаева Г.Г. Сахарный диабет: ангиопатии и окислительный стресс. М., 2003. 86 с.

Можейко Л.А. Экспериментальные модели для изучения сахарного диабета. Журн. Гродненского государственного мед. ун-та. 2013. № 3. С. 26–29.

Thompson R.H., Lane B.R., Lohse C.M. et al. Every minute counts when the renal hilum is clamped during partial nephrectomy. Eur. Urol. 2010. Vol. 58. P. 340–345.

Bhayani S.B., Rha K.H., Pinto P. et al. A Laparoscopic partial nephrectomy: effect of warm ischemia on serum creatinine. J. Urol. 2004. Vol. 172. P. 1264–1266.