DOI: https://doi.org/10.26641/2307-5279.23.4.2019.187217

Etiology of chronic kidney disease in children

S.V. Kushnirenko

Abstract


Objective: to study the etiological structure of primary renal diseases, as the causes of CKD 1–5 st. in children.

Research materials and methods. To determine the etiological structure of CKD in children, an analysis of 326 case histories of patients aged 2 to 17 years was performed.

Results and discussion. In the structure of CKD, the leading positions are occupied by CAKUT – 52.8%, chronic glomerulonephritis – 19.6% and polycystic kidney disease – 8.6%. The largest number of patients (37.4%) with CKD 1–5 st. it is in the age range of 13–17 years.

Summary. A detailed analysis of the nosological structure of CKD in a population of children allows us to identify priority areas for improving diagnosis and using timely renoprotection methods to slow the progression of CKD.

Keywords


etiology; chronic kidney disease; children

References


Игнатова М.С., Морозов С.Л., Крыганова Т.А. и др. Современные представления о врожденных аномалиях органов мочевой системы (синдром CAKUT) у детей. Клиническая нефрология. 2013. № 2. С.58–64.

Becherucci F., Roperto RM., Materassi M., Romagnani P. Chronic kidney disease in children. Clin. Kidney J. 2016. Vol. 9, No. 4. P. 583–591.

Connaughton D.M., Kennedy C., Shril S. et al. Monogenic causes of chronic kidney disease in adults. Kidney International. 2019. Vol. 95, No. 4. P. 914–928.

Harambat J. J., van Stralen K., Kim J., Tizard J. Epidemiology of chronic kidney disease in children. Pediatric Nephrology. 2012. Vol. 27, No. 3. Р. 363–373.

National Kidney Foundation. Pediatric GFR Calculator. URL: https://www.kidney.org/professionals/KDOQI/gfr_calculatorPed.

Kidney Disease: Improving Global Outcomes (KDIGO) СKD Work Group. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Inter. 2013. No. 3. Р. 1–150.

National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney diseases: evaluation, classification and stratification. Am. J. Kidney Dis. 2002. Vol. 39. P. 17–31.