Prognostic significance of immunohystochemical markers in prostate intraepithelial neoplasia

Authors

  • M.P. Melnychuk SIS “Research and practical center of preventive and clinical medicine” SAD, Ukraine
  • O.O. Lulko Zaporizhzhya regional clinical hospital, Ukraine
  • A.Z. Zhuravchak SIS “Research and practical center of preventive and clinical medicine” SAD, Ukraine

DOI:

https://doi.org/10.26641/2307-5279.22.3.2018.143273

Keywords:

prostate intraepithelial neoplasia, immunohystochemical markers, prostate cancer

Abstract

The article is dedicated to diagnostics of prostate intraepithelial neoplasia (PIN), that is considered to be prostate precancerous process. Expression of proliferation (Ki-67), invasion (p63) and progression (AMACR) tissue markers was analised in patients with PIN who had malignisation. 74 patients with benign prostate hyperplasia and PIN were examined. During 3-year follow up period were detected 23 prostate cancer cases. The expression rate of immunohystochemical markers was assessed in comparing with median expression rate in patients with high grade PIN. It was determined that Ki-67 expression in PIN with malignant progression is 8,6 % bigger than in PIN without detected PC and correlates with high PC probability. p63 expression in PIN with malignant progression is 16,7 % smaller than in PIN without detected PC and has inverse correlation with high PC probability. AMACR expression in PIN with malignant progression is 16,7 % bigger than in PIN without detected PC and correlates with high PC probability. Immunohystochemical examination with Кі-67, р63 and AMACR markers level detection has a prognostic significance for stratification of risk group of malignisation and extended examination of patients with PIN including rebiopsy.

References

Рак в Україні, 2015–2016. Бюлетень національного канцер-реєстру України / Колеснік О.О., Федоренко З.П., Гулак Л.О., Михайлович Ю.Й. – Київ, 2017.

Сайдакова Н.О., Григоренко В.М. Рак передміхурової залози: захворюваність в Україні //Урологія. – 2015. – Том 19, № 3. – С. 48–54.

Haffner M., Barbieri C. Shifting paradigms for high-grade prostatic intraepithelial neoplasia //European Urology. – 2016. – Vol. 69, N 5. – P. 831–833.

Taneja S., Morton R. Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene // J. Clin. Oncol. – 2013. – Vol. 31. – P. 523–529.

De Nunzio C., Albissini S., Cicione A., Gacci M. Widespread High-grade Prostatic Intraepithelial Neoplasia on biopsy predicts the Risk of Prostate Cancer // Archivio Italiano di Urologia e Andrologia. – 2013. – Vol. 85, N 2. – P. 59–64.

Tao Z., Shi A. Epidemiology of prostate cancer: current status // European review for Medical and Pharmakological Sciences. – 2015. – Vol. 19. – P. 805–812.

Brosman A., Kim D. Precancerous Lesions of Prostate // Medscape. – 2014. – Vol. 31. – P. 132–139.

Park K., Dalton J. TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia // J. Clin. Oncol. – 2014. – Vol. 32, N 3. – P. 206–211.

Morais C., Han J., Gordetsky J., et al. Utility of PTEN and ERG immunostaining for distinguishing high-grade PIN from intraductal carcinoma of the prostate on needle biopsy // Am J Surg Pathol. – 2015. – Vol. 39. – P. 169–178.

Park K., Dalton J., Narayanan R., et al. TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia // J Clin Oncol. – 2014. – Vol. 32. – P. 206–211.

Patel P., Nayak Y., Biljetina Z., Donnelly B. Prostate cancer after initial PIN and benign prostate biopsy // The Canadian Journal of Urology. – 2015. – Vol. 22. – P. 8056–8062.

Аллина Д.О., Кекеева Т.В. Диагностическая значимость оценки экспрессии ERG в аденокарциноме предстательной железы и простатической интраэпителиальной неоплазии высокой степени // Архив патологии. – 2015. – № 5. – С. 36–42.

Туманский В.А., Попович А.А., Попович С.А., Туманская Л.М. Иммуногистохимические дифференциально-диагностические особенности доброкачественной гиперплазии, интраэпителиальной неоплазии и рака предстательной железы // Морфология. – 2016. – Том 10, № 3. – С. 297–301.

Published

2018-09-27

Issue

Section

Oncourology