COMPARISON OF SYSTEMIC AND LOCAL APPLICATION OF TRANEXAMIC ACID ON BLEEDING AND BLOOD TRANSFUSION NEED IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS

Автор(и)

  • Negar Mazaheri
  • Mohammad Bagher Khosravi

DOI:

https://doi.org/10.32461/2226-3209.3.2018.178839

Анотація

Abstract: Comparison of the effect of systemic administration and transamine position on bleeding and the need for blood transfusion in patients undergoing coronary artery bypass surgery, goals, comparing the amount of bleeding and blood transfusion in 48 hours after surgery, design by random sampling by blocking, 180 patients will enter this study, How to do after seeking consent, 60 patients will be assigned to the systemic intervention group and 60 patients will be assigned to the intervention group and 60 patients will be in the control group. Entry requirements: All patients undergoing coronary artery bypass graft surgery for the first time. Exclusion criteria in patients with renal failure, anemic patients, patients with low cardiac output, patients with coagulation disorder, and intervention; patients undergoing anesthesia induction of 10 mg / kg of body weight within the regimen Receive a dose of 1 mg of the drug per kg body weight per surgical hour until the end of surgery, after the surgery. In the local group, 1 g of the transamine solution was dissolved in 100 ml of chloride. 0.9% at the end of the surgery in the pericardial cavity of the heart. 60 patients will not receive the drug control group, all of the surgery will be performed by two surgeons under the same anesthetic and bypass procedure, the main outcome of the cerebral hemorrhage 6, 12, 24, 48 hours after surgery, and the rate of blood transfusion in 48 hours. From surgery.
Key word: Local Tranexamic acid, systemic tranexamic acid, coronary artery bypass surgery, bleeding, blood transfusion

Посилання

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