Design of consrtuction and hydrodynamic modeling in a roller bioreactor with surface cultivation of cell cultures
DOI:
https://doi.org/10.15587/2313-8416.2017.107176Keywords:
bioreactor, cell cultivation, computer modeling, hydrodynamics, shear stress, immobilized eukaryotic cellsAbstract
Design of construction of a bioreactor for the cultivation of cell cultures is developed and computer modeling of hydrodynamic apparatus is carried out. The field of velocity vectors of the fluid in the apparatus, the shear rate for a fluid, the fluid shear stress in the area of cell immobilization are obtained. The obtained results confirm the technological effectiveness of bioreactor construction and can be used in the design of pilot samples of the apparatus
References
Shybetskуу, V. Yu., Semeniuk, S. M. (2017). Accounting for the needs of producers in the design of fermentation equipment. Biotechnology of the XXI century. Kyiv: Ed. "Politekhnica", 184.
Nedovic, V., Willaert, R. (Eds.) (2013). Fundamentals of Cell Immobilisation Biotechnology. Berlin: Springer Science & Business Media, 555. doi: 10.1007/978-94-017-1638-3
Eibl, D., Eibl, R., Portner, R. et. al. (2009). Cell and Tissue Reaction Engineering: Principles and Practice. Berlin: Springer, 363. doi: 10.1007/978-3-540-68182-3_1
Semeniuk, S. M., Shybetskуу, V. Yu. (2016). Bioreactors for cultivation cell culture. Topical issues of biology and ecology development. Vinnitsa, 306–308.
Bioreaktoren und fermentationssysteme. Available at: http://www.zeta.com/bioraktoren_161.htm
WAVE Bioreactors – GE Healthcare Life Sciences. Available at: http://www.gelifesciences.com/webapp/wcs/stores/servlet/CategoryDisplay?categoryId=3325260&catalogId=130619&productId=&top=Y&storeId=11251&langId=-1
Freshni, R. Ya. (2010). Culture of animal cells. Moscow: BINOM. Laboratory of knowledge, 691.
AcuSyst-Xcellerator – C3 Cell Culture Company. Available at: https://static1.squarespace.com/static/5822091e46c3c4379874dc14/t/58824a4d725e250cb2826d0e/1484933709324/CCCO_A4+AcuSyst+Xcellerator_ACV1_V4+%281%29.pdf
iCELLis® Bioreactor – Bioreactors Company. Available at: https://shop.pall.com/INTERSHOP/web/WFS/PALL-PALLUS-Site/en_US/-/USD/ViewProduct-Start?SKU=hw7uq21l
Sharma, C., Malhotra, D., Rathore, A. S. (2011). Review of Computational fluid dynamics applications in biotechnology processes. Biotechnology Progress, 27 (6), 1497–1510. doi: 10.1002/btpr.689
Guyot, Y., Luyten, F. P., Schrooten, J., Papantoniou, I., Geris, L. (2015). A three-dimensional computational fluid dynamics model of shear stress distribution during neotissue growth in a perfusion bioreactor. Biotechnology and Bioengineering, 112 (12), 2591–2600. doi: 10.1002/bit.25672
Kopylenko, A. V., Semeniuk, S. M., Shybetskуу, V. Yu., Kostyk, S. I. (2017). Innovative concept of hydrodynamic modeling in a roller bioreactor with surface cultivation of cell cultures. Science new NUFT, 23 (2), 114–122.
Kostyk, S. I., Ruzhinskaya, L. I., Shybetskуу, V. Yu., Revtov, O. О. (2016). Mathematical simulation of hydrodynamics of the mixing device with magnetic drive. ScienceRise, 4 (2 (21)), 27–31. doi: 10.15587/2313-8416.2016.67275
Gelbgras, V., Wylock, C. E., Drugmand, J.-C., Haut, B. (2011). Segregated Model of Adherent Cell Culture in a Fixed-Bed Bioreactor. Chemical Product and Process Modeling, 6 (1). doi: 10.2202/1934-2659.1522
Downloads
Published
Issue
Section
License
Copyright (c) 2017 Vladyslav Shybetskiy, Serhii Semeniuk, Sergiy Kostyk
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
