Indicators of inflammatory response in chronic kidney disease and their dynamics on the background of pharmacological correction
Keywords:chronic kidney disease, glomerulonephritis, acute phase proteins, haptoglobin, ceruloplasmin, α-2-macroglobulin
In recent years the course processes of chronic glomerulonephritis viewed from a position of influence nonimmune factors. In the present research, in contrast to the existing, it is researched an intensity of acute phase response depending on the stage of chronic kidney disease and studied the dynamics of changes of inflammatory response against the background of different pharmacological regimens.
Methods. Using standard biochemical tests to study the intensity of inflammatory response in chronic kidney disease of serum are studied protein content of acute phase: ceruloplasmin, haptoglobin, α-2-macroglobulin. The study involved 100 people. 80 of these people have chronic kidney disease. At hypertension was prescribed medicine of inhibitor of angiotensin-converting enzyme in combination with calcium channel blockers on a background of basic therapy.
Results. In all groups of patients before treatment it is recorded a high activity of serum of investigated proteins of acute phase, reflecting the presence of active inflammation. In the context of the treatment an inflammation activity is decreased, causing regression of the inflammatory response indicators. With the growth of the studied parameters in the 2 - 2, 5 times it is diagnosed a high degree of inflammatory response. This degree was determined in patients with chronic kidney disease of third stage. The lowest degree of inflammatory response was typical for patients with first stage of the disease, improving all parameters were within 1.3 times relative to control values.
Conclusions. The inflammation intensity in chronic kidney disease depends on the progression of renal dysfunction. To correct the intensity of inflammatory response is recommended to use the fixed combination of inhibitor of angiotensin-converting enzyme (fozinopril) and calcium channel blockers (diltiazem).
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