The experience of thermal imaging application in clinical oncology


  • Галина Степановна Ефимова Kharkiv Regional Clinical Oncological Center Lisoparkivska, 4, Kharkiv, Ukraine, 61070, Ukraine



oncology, thermal imaging, diagnostics, chemoradiotherapy, local side reactions


Both the tumors themselves and the toxic reactions on chemoradiotherapy (CRT) manifest in changes of thermal fields in the skin surface that gives a possibility of using non-invasive thermal imaging technique for diagnostics and monitoring. The purpose of the study is detection and preliminary analysis of dynamics of the anomalous thermal areas emerged at the skin surface of the oncology patients treated with CRT, and also establishing correlations of these thermal anomalies with the toxic reactions.

Methods. Using thermal imaging method, 100 oncology patients with various tumors thus treated with CRT under different regimens were repeatedly examined.

Results:  A clear correlation has been found between dynamics of the anomalous thermal areas and development of the toxic reactions. Periodic general thermal examination of the patients during their treatment gave an additional thermal imaging method opportunity of revealing new malignancies, metastases and other deteriorations of health status.

Conclusions. Preliminary analysis of thermal anomalies on patients’ skin surface has demonstrated that the thermal imaging method is principally applicable to monitor the severity of local CRT-caused toxic reactions.

Author Biography

Галина Степановна Ефимова, Kharkiv Regional Clinical Oncological Center Lisoparkivska, 4, Kharkiv, Ukraine, 61070

PhD of medicine

Deputy director 


Diakides, N. A. (2007). Medical Infrared Imaging, CRC Press, 448. doi: 10.1201/9781420008340

Degtyarev, Yu. P., Nichiporuk, V.I., Mironenko, S.A. et al. (2010). Mesto i rol distancionnoy infrakrasnoy termografii sredi sovremennyh diagnosticheskih metodov [The place and role of remote infrared thermography among modern diagnostic methods]. Electronics and Communications, 2, 192–196.

Ng, E. Y., Ung, L. N., Ng, F. C., Sim, S. J. (2001). Statistical analysis of healthy and malignant breast thermography. Engineering and Technology, 25 (6), 253–263.

Gautherie, M. (1989). Atlas of breast thermography with specific guidelines for examination and interpretation. Milan, Italy: PAPUSA, 256.

Cohen, E., Ahmed, O., Kocherginsky, M. et al. (2013) Study of Functional Infrared Imaging for Early Detection of Mucositis in Locally Advanced Head and Neck Cancer Treated With Chemoradiotherapy. Oral Oncology, 49 (10), 1025–1031. doi: 10.1016/j.oraloncology.2013.07.009

Literature Review of Breast Thermography. Available at:

Gubkin, S. V. (2002). Atlas termogram v revmatologii [Atlas thermograms in rheumatology]. Minsk: Technoprint, 116

AFRL. Medatr database using vdl (2003). Available at:

Qi, H., Diakides, N. Infrared Imaging in Medicine. Available at:

Shustakova, G. V., Vinnik, Yu. A., Yefimova, G. S. et al. (2013). Termografy FTINT NAN Ukrainy: medicinskiy aspect [Thermographs of the Institute for Low Temperature Physics and Engineering of NAS of Ukraine: Medical Aspects]. Radiodiagnostics. Radiotherapy, 1, 27–33.

Yefremenko, V., Gordiyenko, E., Shustakova, G. et al. (2009). A Broadband Imaging System for Research Application. Review of Scientific Instrument, 80 (5), 056104. doi: 10.1063/1.3124796

Gordienko, E., Shustakova, G., Fomenko, Yu., Glushchuk, N. (2012). Multi-element Thermal Imaging System Based on Uncooled Bolometric Array. Instruments and Experimental Techniques, 55 (4), 494–497.

Mabuchi, R. Chinzei, T., Fujimasa, I. et al. (1998). Evaluating asymmetrical thermal distributions through image processing. IEEE Engineering in Medicine and Biology Magazine, 17 (2), 47–55. doi: 10.1109/memb.1998.687963

Tkachenko, Yu. A. (1998). Klinicheskaya termografiya (obzor osnovnyh vozmozhnostey) [Clinical Thermography (overview of key features)]. Nizhniy Novgorod, Russia: ZAO Soyuz Vostochnoy I Zapadnoy Mediciny, 270

Ivanitskii, G. R., Deev, A. A., Krest’eva, I. B. et al. (2004). Characteristics of Temperature Distributions around the Eyes. Doklady Biological Sciences, 398 (1-6), 367–372. doi: 10.1023/b:dobs.0000046658.90357.2d

Yefimova, G. S., Vinnik, Yu. A., Glushchuk, N. I. et al. (2013). Termograficheskiy control sostoyaniya pacientov pri himioterapii [Thermal monitoring of patients during chemotherapy]. practically scientific conference "New methods of diagnosis and treatment of oncologic diseases". Kharkov (Ukraine), 38.

Shustakova, G. V., Vinnik, Yu. A., Yefimova, G. S. et al. (2013). Teploviziyny control rivnya toksychnyh reakciy pry himioterapii [Thermal Imaging Method for Monitoring the Level of Toxicity During Chemoradiotherapy] Proceedings of BMIC-2013 (Biological and Medical Informatics and Cybernetics), Zhukin (Ukraine), 1–4.