Positive experience of application of ethylmethylhydroxypyridine succinate for patients with a sharp and chronic cerebral ischemia of brain
DOI:
https://doi.org/10.15587/2313-8416.2015.42044Keywords:
heterogeneous ischemic stroke, chronic ischemic disturbances of brain circulation, Mexiprim, neurological deficitsAbstract
Cerebrovascular diseases are the major factor of medical and social problems of contemporaneity. During our work we estimated efficiency of application of Mexiprim regressed neurological deficit, mortality; improved performance outcomes of stroke (Barthel ADL index, mRS) and cognitive and memory functions of the central nervous system in patients with chronic ischemic disturbances of brain circulation.
Methods. To solve the problem from 1 February 2014 to 1 February 2015 we surveyed 35 (n1) of patients after stroke heterogeneous and 65 (n2) patients with and chronic ischemic disturbances of brain circulation. The control group consisted of 27 patients (n1) with ischemic stroke and 58 patients (n2) with chronic ischemic. All the patients we conducted clinical neurological, neuropsychological examination.
Results. During the initial inspection and continuous dynamic monitoring of patients with ischemic stroke, we obtained the following results. The minimum amount of points (7) NIHSS score was in the main group of patients after 24 and 72 hours of 12 and 17 patients, respectively, and in the control group, the minimum score was observed at 6 and 10 patients, respectively. Barthel index of activity in the 21 days of treatment in the study group was 85 + 5, in the control 65+5 (p <0.01). When analyzing the performance of the modified Rankin scale score of 1 point in the main observation group scored 17 patients in the control group - 8 patients; 4 points - 0 and 2 patients, respectively. In assessing cognitive function using the scale brief study of the psychological status (MMSE) 21 days from the start of dosing patients Mexiprim indicators improved significantly: points on a scale MMSE 28+0.5 (p<0.01), during the test hours total point reached 10 (p <0.01).
Conclusions. Application Mexiprim a complex scheme of assignments to reduce neurological deficits, mortality, improve the performance outcomes of stroke (Barthel ADL index, mRS) and cognitive and memory functions of the central nervous system in patients with chronic ischemic, that allows us to recommend use of the drug in the complex therapy of patients with heterogeneous ischemic stroke and chronic ischemic disturbances of brain circulation
References
Belovol, A. N., Knjazkova, I. I. (2009). Perspektivy farmakologicheskoj korrekcii gipoksii v kardionevrologii i nevrologii. Lіki Ukraini, 2 (128), 65–72.
Vereshhagin, N. V. (2006). Geterogennost' insul'ta v klinicheskoj praktike. Al'manah № 1. Akademija insul'ta, 4–7.
Mishhenko, T. S. (2007). Sovremennye podhody k lecheniju bol'nyh discirkuljatornoj jencefalopatiej. Zdorov'e Ukrainy. Tematicheskij nomer «Nevrologija i psihiatrija», 5, 21.
Mureshanu, D. F. (2007). Kompleksnyj podhod v nejroprotekcii i nejroplastichnosti pri lechenii insul'ta. Mezhdunar. nevrolog, zhurn., 6 (16), 63–66.
Parfenov, V. A. (2008). Discirkuljatornaja jencefalopatija: Differencial'nyj diagnoz i lechenie. Klinicist. Moscow: ABV-press.
Vereshhagin, N. V., Piradov, M. A., Suslina, Z. A. (2008). Insul't: principy diagnostiki, lechenija i profilaktiki. Moscow: Medicina, 176.
Gusev, E. I., Skvorcova, V. I. (2002). Nejroprotektivnaja terapija ishemicheskogo insul'ta. Pervichnaja nejroprotekcija. Zhurn. Nevropatologii i psihiatrii im. S. S. Korsakova. Insul't, prilozhenie k zhurnalu, 5, 3–16.
Evtushenko, S. K. (2010). Ot jetiologii podvidov insul'tov u lic molodogo vozrasta – k ih jeffektivnomu lecheniju i profilaktike. Aktual'nі naprjamki v nevrologi: s'ogodennja ta majbutne. Sudak, 12–18.
Zaharov, V. V., Jahno, N. N. (2005). Kognitivnye rasstrojstva v pozhilom i starcheskom vozraste: Metodicheskoe posobie dlja vrachej. Moscow, 70.
Zvereva, Z. F. (2010). Klinicheskie i nejrofiziologicheskie pokazateli u bol'nyh s discirkuljatornoj jencefalopatiej. Zhurnal nevrologii i psihiatrii im. S. S. Korsakova, 2, 15–18.
Kadykov, A. S., Manvelov, L. S., Shahparonova, N. V. (2013). Hronicheskie sosudistye zabolevanija golovnogo mozga: discirkuljatornaja jencefalopatija: rukovodstvo dlja vrachej. Second edition. Moscow: GJeOTAR-Media, 232.
Levin, O. S. (2006). Discirkuljatornaja jencefalopatija: sovremennye predstavlenija o mehanizmah razvitija i lechenii. Consilium Medicum, 8 (8).
Mishhenko, T. S. (2006). Discirkuljatornaja jencefalopatija: sovremennye vzgljady na patogenez i diagnostiku. Zdorov 'ja Ukraini, 15-16.
Piradov, M. A., Rumjanceva, S. A. (2005). Nejroprotektivnaja terapija v angionevrologii. RMZh, 13 (15), 980–983.
Fedin, A. I., Rumjanceva, S. A., Kuznecov, O. R. et. al. (2004). Antioksidantnaja i jenergoprotektornaja terapija ishemicheskogo insul'ta. Moscow, 48.
Argentine, C., Prencipe, M. (2006). The burden of stroke: a need for prevention // Prevention of Ischemik stroke. Lviv: Martin Dunitz, 1–5.
Doufekias, E., Segal, A., Kizer, J. (2008). Cardiogenic and aortogenic brain embolism. Journal of the American College of Cardiology, 51 (11), 1049–1059. doi: 10.1016/j.jacc.2007.11.053
Henriques, I. E., Barata, S., Gondar, P. et al. (2008). Stroke as first as manifestation of cardiac disease. Cerebrovasc. Dis., 13 (S3), 34–44.
Manica, G. (2004). Prevention and treatment of stroke in patients with hypertension. Clinical Therapeutics, 26 (5), 631–648. doi: 10.1016/s0149-2918(04)90065-3
Sarti, C., Rastenyte, D., Cepaitis, Z. et al. (2000). International trends in mortality from stroke, 1968–1994. Sroke, 31 (7), 1588–1601. doi: 10.1161/01.str.31.7.1588
Rumjanceva, S. A., Afanas'ev, V. V., Silina, E. V. (2009). Patofiziologicheskaja osnova kompleksnoj nejroprotekcii pri ishemii mozga. Zhurnal i psihiatrii im. S. S. Korsakova, 3 (109), 64–68.
Rumjanceva, S. A., Fedin, A. I., Afanas'ev, V. V. et. al. (2010). Algoritm terapii ostrogo insul'ta. Novosti mediciny i farmacii. Specvypusk «Nevrologija», 328, 25–30.
Skvorcova, V. I., Efremova, N. V., Shamalov, N. A. et. al. (2006). Cerebral'naja ishemija i nejroprotekcija. Medicina: Insul't, 2 (13), 35–42.
Suslina, Z. A. (2006). Ishemicheskij insul't: principy lechenija v ostrejshem periode. Al'manah № 1. Akademija insul'ta, 22–44.
Suslina, Z. A., Varakin, Ju. Ja., Vereshhagin, N. V. (2006). Sosudistye zabolevanija golovnogo mozga. Moscow: Medpress-inform, 254.
Downloads
Published
Issue
Section
License
Copyright (c) 2015 Игорь Васильевич Юров
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
