Influence of zero-valent iron nanoparticles’ oral administration on the myometrial contractility in mice with experimental iron deficiency anemia

Authors

  • Аліна Петрівна Литвиненко Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine 4 Bogomoletz str., Kyiv, Ukraine, 01601, Ukraine
  • Людмила Сергіївна Рєзніченко F. D. Ovcharenko Institute of Biocolloidal Chemistry National Academy of Sciences of Ukraine, 42 Vernadskogo blvd., Kyiv, Ukraine, 03142, Ukraine
  • Андрій Михайлович Дорошенко Bohomolets National Medical University Ukraine, Kyiv, 01601, Pobedy Av., 34, Ukraine
  • Тарас Вірославович Блашків Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine 4 Bogomoletz str., Kyiv, Ukraine, 01601, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2015.45059

Keywords:

iron deficiency anemia, myometrium, contractility, zero-valent iron nanoparticles, oral administration, influence

Abstract

The peculiarities of changes in blood markers (hemoglobin concentration, hematocrit, number of red blood cells) and the contractility parameters of ovarian and cervical parts of uterus in ВАLB/с mice with iron deficiency anemia under conditions of zero-valent iron nanoparticles’ oral administration have been studied. It has been revealed that 10-fold oral administration of the nanoparticles to the animals with iron deficiency anemia induces normalization of the analyzed blood parameters

Author Biographies

Аліна Петрівна Литвиненко, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine 4 Bogomoletz str., Kyiv, Ukraine, 01601

Graduate student

Department of Immunophysiology

Людмила Сергіївна Рєзніченко, F. D. Ovcharenko Institute of Biocolloidal Chemistry National Academy of Sciences of Ukraine, 42 Vernadskogo blvd., Kyiv, Ukraine, 03142

Candidate of Biological Sciences, Senior research scientist

Department of colloidal technology of natural systems

Андрій Михайлович Дорошенко, Bohomolets National Medical University Ukraine, Kyiv, 01601, Pobedy Av., 34

Postgraduate student

Department of pharmacology and clinical pharmacology

Тарас Вірославович Блашків, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine 4 Bogomoletz str., Kyiv, Ukraine, 01601

Candidate of Biological Sciences, Senior research scientist

Department of Immunophysiology

References

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Published

2015-06-25

Issue

Section

Biological sciences