Special features of sleep disorders and depressive disturbances in patients with isolated gastroesophageal reflux disease and in conjunction with coronary artery disease

Authors

  • Галина Дмитриевна Фадеенко Government Institution «L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine 2a Postysheva avе., Kharkiv, Ukraine, 61039, Ukraine
  • Елена Вячеславовна Измайлова Government Institution «L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine 2a Postysheva ave., Kharkiv, Ukraine, 61039, Ukraine
  • Елена Олеговна Крахмалова Government Institution «L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine 2а Postysheva avе., Kharkiv, Ukraine, 61039, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2015.52184

Keywords:

gastroesophageal reflux disease, coronary artery disease, comorbidity, sleep disorders, depression

Abstract

Aim – to study the special features of sleep disorders and depression intensity in patients with gastroesophageal reflux disease (GERD) and GERD in conjunction with coronary artery disease (CAD) by the method of questionnaire and to compare results with clinical and functional manifestations of comorbidity.

Methods. There were examined 65 patients with GERD and CAD (group 1) and 29 patients with GERD (group 2). Sleep disorders and depression were studied using questionnaires: subjective sleep characteristics (SSC), (Epworth Sleepiness Scale (ESS),Beck scale for depression (BSD).

Results. Sleep disorders took place in 41 (61,54 %) patients from group 1 and 13 (44,83 %) patients from group 2. The mean point of SSC was 17,75±1,98 in group 1 opposite to18,59±1,12 in group 2 (p= 0,043). The mean point of ESS was 9,75±1,59 in group 1opposite to 9,24±1,18 in group 2, p=0,103. The mean point of BDS was 11,89±4,38 in group 1opposite to 8,86±1,30 in group 2, p= 0,004. In the group 1 it was established a correlation between SSC and patient’s age (r=- 0320; p=0,0075), BSD and age (r=0,371; p=0,0024), ESS and body mass index(r=0,291; p=0,0188). There were established correlations between duration of CAD and SSC (r=-0,315; p=0,011), CAD and ESS (r=0,273; p=0,0280), CAD and BSD (r=0,379; p=0,0018), GERD heaviness and SSC (p=0,0498), BSD and SSC (r= - 0,676; p=0,000) and between BSD and ESS (r=0,583; p=0,000) in group 1. In group 2 ESS correlated with age (r=0,379; p=0,0426).

Conclusions. The conjunction of GERD and CAD can be considered as two mutually potential pathological processes that have a negative effect on such indicators as sleep and psycho-emotional status of patient

Author Biographies

Галина Дмитриевна Фадеенко, Government Institution «L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine 2a Postysheva avе., Kharkiv, Ukraine, 61039

Doctor of medical Sciences, Professor

Department of liver disease and gastro -intestinal tract pathology 

Елена Вячеславовна Измайлова, Government Institution «L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine 2a Postysheva ave., Kharkiv, Ukraine, 61039

Рostgraduate student Department of liver disease and gastro -intestinal tract pathology

Елена Олеговна Крахмалова, Government Institution «L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine 2а Postysheva avе., Kharkiv, Ukraine, 61039

Doctor of medical Sciences, Senior Researcher, head of the department

The Cardiopulmonology department 

References

Qubty, W. F., Mrelashvili, A., Kotagal, S., Lloyd, R. M. (2014). Comorbidities in Infants with Obstructive Sleep Apnea. Journal of Clinical Sleep Medicine, 10 (11), 1213–1216 doi: 10.5664/jcsm.4204

Song, Y., Dzierzewski, J. M., Fung, C. H., Rodriguez, J. C., Jouldjian, S., Mitchell, M. N. et. al (2015). Association Between Sleep and Physical Function in Older Veterans in an Adult Day Healthcare Program. Journal of the American Geriatrics Society, 63 (8), 1622–1627. doi: 10.1111/jgs.13527

Freidin, N., Fisher, M. J., Taylor, W., Boyd, D., Surratt, P., McCallum, R. W., Mittal, R. K. (1991). Sleep and nocturnal acid reflux in normal subjects and patients with reflux oesophagitis. Gut, 32 (11), 1275–1279. doi: 10.1136/gut.32.11.1275

Pasechnikov, V. D., Pasechnikov, D. V. (2008). Kak dobit'sja maksimal'noj jeffektivnosti medikamentoznoj terapii gastrojezofageal'noj refljuksnoj bolezni. Farmateka, 13, 76–80.

Wahlqvist, P., Karlsson, M., Johnson, D., Carlsson, J., Bolge, S. C., Wallander, M.-A. (2008). Relationship between symptom load of gastro-oesophageal reflux disease and health-related quality of life, work productivity, resource utilization and concomitant diseases: survey of a US cohort. Alimentary Pharmacology & Therapeutics, 27 (10), 960–970. doi: 10.1111/j.1365-2036.2008.03671.x

Akarachkova, E. S., Kotova, O. V., Rjabokon', I. V. (2014). Deperessija i insomnija u pacientov s IBS. Stat'ja Med. sonet., 11, 50–54.

Zvenigorodskaja, L. A., Taranchenko Ju. V. (2006). Osobennosti techenija gastrojezofageal'noj refljuksnoj bolezni u pozhilyh bol'nyh s soputstvujushhej ishemicheskoj bolezn'ju serdca. Terapevticheskij arhiv, 78 (2), 42–45.

Babak, O. Ja., Fadeenko, G. D. (2000). Gastrojezofageal'naja refljuksnaja bolezn'. Kyiv: Interfarma-Kiev, 175.

Chey, W. D., Mody, R. R., Wu, E. Q., Chen, L., Kothari, S., Persson, B. et. al (2009). Treatment patterns and symptom control in patients with GERD: US community-based survey. Current Medical Research and Opinion, 25 (8), 1869–1878. doi: 10.1185/03007990903035745

Eganjan, G. A. (2006). Nebenzodiazepinovye anksiolitiki v kompleksnoj terapii gastrojezofageal'noj refljuksnoj bolezni i nejazvennoj dispepsii zheludka. Lechashhij vrach, 7. Available at: http://www.gastroscan.ru

Paykel, E., Brugha, T., Fryers, T. (2006). Masshtaby i bremja depressivnyh rasstrojstv v Evrope (rasshirennyj referat obzora). Psihiatrija i psihofarmakoterapija, 8 (3), 40–43.

Schneider, H. (2007). Gastro-oesophageal reflux disease: The Montreal definition and classification. South African Family Practice, 49 (1), 19–26. doi: 10.1080/20786204.2007.10873501

Butler, N. (2009). National Guidelines at a glance: GO. SA Pharmaceutical Journal, 10, 32–36.

Kahrilas, P. J., Shaheen, N. J., Vaezi, M. F. (2008). American Gastroenterological Association Medical Position Statement on the Management of Gastroesophageal Reflux Disease. Gastroenterology, 135 (4), 1383–1391.e5. doi: 10.1053/j.gastro.2008.08.045

Gastrojezofageal'naja refljuksnaja bolezn' (2007). Ukrainskij medicinskij portal "Evrolab", 8. Available at: http://www.eurolab.ua

Levin, Ja. I. (2007). Son. stress. Insomnija. Lechashhij vrach, 5. Available at: http://www.lvrach.ru

Muray, W. (1991). A new method of Measuring Daytime sleepiness: the Epworth sleepiness scale. Sleep, 14 (6), 540–545.

Il'in, E. P. (2001). Jemocii i chuvstva. Sankt-Peterburg: «Piter», 749

Martinez, D., da Silva, R. P., Klein, C., Fiori, C. Z., Massierer, D., Cassol, C. M. et. al (2011). High risk for sleep apnea in the Berlin questionnaire and coronary artery disease. Sleep and Breathing, 16 (1), 89–94. doi: 10.1007/s11325-010-0460-2

Saleh, D. K., Nouhi, S., Zandi, H., Lankarani, M. M., Assari, S., Pishgou, B. (2008). The quality of sleep in coronary artery disease patients with and without anxiety and depressive symptoms.Indian Heart J., 60 (4), 309–312.

Kljaritskaja, I. L., Balabanceva, A. P., Kolesnichenko, A. I. (2011). Taktika lechenija insomnii pri refrakternoj gastrojezofageal'noj refljuksnoj bolezni. Krymsk. terapevt. zhurn., 2, 126–130.

Fass, R., Sifrim, D. (2009). Management of heartburn not responding to proton pump inhibitors. Gut, 58 (2), 295–309. doi: 10.1136/gut.2007.145581

Fujiwara, Y., Habu, Y., Ashida, K., Kusano, M., Higuchi, K., Arakawa, T. (2013). Sleep Disturbances and Refractory Gastroesophageal Reflux Disease Symptoms in Patients Receiving Once-Daily Proton Pump Inhibitors and Efficacy of Twice-Daily Rabeprazole Treatment. Digestion, 88 (3), 145–152. doi: 10.1159/000354071

Jha, L. K., Maradey-Romero, C., Gadam, R., Hershcovici, T., Fass, O. Z., Quan, S. F. et. al (2014). The effect of antireflux treatment on the frequency of awakenings from sleep in patients with Gastroesophageal reflux disease. Neurogastroenterology & Motility, 27 (2), 237–245. doi: 10.1111/nmo.12481

Johansson, A., Svanborg, E., Swahn, E., Ejdebäck, J., Tygesen, H., Edell-Gustafsson, U. (2011). Sleep, arousal and health-related quality of life in men and women with coronary artery disease. Journal of Clinical Nursing, 20 (19-20), 2787–2801. doi: 10.1111/j.1365-2702.2011.03787.x

Mallon, L., Broman, J.-E., Hetta, J. (2002). Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population. Journal of Internal Medicine, 251 (3), 207–216. doi: 10.1046/j.1365-2796.2002.00941.x

Saleh, D., Nouhi S, Zandi H, et al. (2008). The quality of sleep in coronary artery disease patients with and without anxiety and depressive symptoms. Indian Heart J., 60 (4), 309–312.

Lee, W., Lee, S., Ryu, H., et al. (2015). Quality of life in patients with obstructive sleep apnea: Relationship with daytime sleepiness, sleep quality, depression, and apnea severity. Chron Respir Dis. Available at: http://www.ncbi.nlm.nih.gov/pubmed

Doesch, C., Süselbeck, T., Haghi, D., Streitner, F., Schoenberg, S. O., Borggrefe, M., & Papavassiliu, T. (2012). The Relationship between the Severity of Coronary Artery Disease and Epicardial Adipose Tissue Depends on The Left Ventricular Function. PLoS ONE, 7 (11), e48330. doi: 10.1371/journal.pone.0048330

Fadeenko, G. D., Mozhina, T. L. (2011). Lechenie gastrojezofageal'noj refljuksnoj bolezni u pacientov s ozhireniem: rol' i mesto sovremennogo prokinetika itoprida gidrohlorida. Suchasna gastroenterologіja, 57 (1), 71–77.

Djärv, T. (2012). Physical activity, obesity and gastroesophageal reflux disease in the general population. World Journal of Gastroenterology, 18 (28), 3710. doi: 10.3748/wjg.v18.i28.3710

Downloads

Published

2015-10-30

Issue

Vol. 10 No. 3 (15) (2015)

Section

Medical Science. Part 2

License

Copyright (c) 2015 Елена Вячеславовна Измайлова, Галина Дмитриевна Фадеенко, Елена Олеговна Крахмалова

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.

Authors, who are published in this journal, agree to the following conditions:

1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.

 2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.