The influence of physical and chemical factors on HCG conservation activity for a long stored in the dilution state

Authors

  • Юрій Іванович Сливчук Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034, Ukraine
  • Ірина Олегівна Матюха Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034, Ukraine
  • Василь Ярославович Сирватка Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034, Ukraine
  • Іван Іванович Гевкан Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034, Ukraine
  • Оксана Всеволодівна Штапенко Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034, Ukraine
  • Наталія Анатоліївна Брода Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2015.53805

Keywords:

chorionic gonadotropin, stabilization, sucrose, L - lysine, liposomal emulsion, hormone activity

Abstract

The activity of new forms of drugs stabilized gonadotropins during prolonged storage was studied. It is established that dispersion leads to loss of 10–12 % the activity of gonadotropin, but the duration of dispersion is not affected. Added stabilizers and liposomal form of the drug maintains the hCG activity at a temperature of 18–20 °C and at 2–4 at the level near 80 %

Author Biographies

Юрій Іванович Сливчук, Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034

Candidate of veterinary sciences, researcher

Laboratory of Reproductive Biotechnology

Ірина Олегівна Матюха, Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034

Candidate of agricultural sciences, researcher

Laboratory of Immunology

Василь Ярославович Сирватка, Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034

Researcher

Laboratory of Reproductive Biotechnology

Іван Іванович Гевкан, Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034

Candidate of biological sciences, researcher

Laboratory of Reproductive Biotechnology

Оксана Всеволодівна Штапенко, Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034

Candidate of agricultural sciences, researcher

Laboratory of Reproductive Biotechnology

Наталія Анатоліївна Брода, Institute of Animal Biology NAAS 38 Vasyl Stus str., Lviv, Ukraine, 79034

Candidate of biological sciences, researcher

Laboratory of Immunology

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Slyvchuk, Yu. I., Hevkan, I. I., Matyukha, I. O., Syrvatka, V. Ya. (2014). Stabilizing the gonadotropin аctivity with the use of organic compounds. Journal of Microbiology, Biotechnology and Food Sciences, 3 (2), 160–163. Available at: http://www.jmbfs.org/wp-content/uploads/2014/01/46_jmbfs_slyvchuk_2014_b.pdf

Published

2015-11-27

Issue

Section

Biological sciences