Comparative assessment of effectiveness and safety of inhalational and intravenous anesthesia at coronary artery bypass in patients of an elderly and old age
DOI:
https://doi.org/10.15587/2313-8416.2015.54640Keywords:
Anesthesia, old age, ischemic heart disease, sevoflurane, propofol, cardioprotectionAbstract
Aim of research. The work deals with an influence of anesthetics (sevoflurane and propofol) that are used at anesthetic management of patients of elderly and old age with ischemic heart disease at coronary artery bypass on postoperative dynamics of cardiospecific enzymes (MB-CPK and Ti I).
Materials and methods. The research included 63 patients of elderly and old age with ischemic heart disease who underwent coronary artery bypass in conditions of artificial blood circulation on the base of SI “Heart institute of MPH of Ukraine”.
The results of research. As the result of research there was revealed that in 12 hours after the end of operation there was observed the growth of MB-CPC values in both groups. But in the group where was used propofol this enzyme indices increased in the mean by 45,9±3,2 % compared to initial value that was 1,4 time more that analogous indices in group where was used sevoflurane.
Тi І values in group with sevoflurane use were in the mean by 29,6±2,7% less than the correspondent values of this enzyme in the group of patients operated in conditions of propofol anesthesia.
Conclusions. So at sevoflurane anesthesia there was detected the more significant cardioprotective effect compared with an intravenous propofol anesthesia that was proved by the dynamics of cardiospecific enzymes in early postoperative period
References
Bokerija, L. A., Skopin, I. I., Nikonov, S. F., Olofinskaja, I. E. (2003). Hirurgicheskoe lechenie zabolevanij serdca u pozhilyh bol'nyh. Annaly hirurgii, 2, 29–32.
Gendlin, G. E., Samsonova, E. V., Buhalo, O. V. (2000). Metodiki issledovanija kachestva zhizni u bol'nyh hronicheskoj nedostatochnost'ju krovoobrashhenija. Serdechnaja nedostatochnost', 1 (2), 44–54.
Ustinov, A. V. (2012). Kardiohirurgija i intervencionnaja kardiologija: problemy i perspektivy razvitija. Ukrayns'kij medichnij chasopis, 1 (87), 8–10.
Ohorona zdorov'ja. Zahvorjuvanist' naselennja (1990–2011) (2012). – Derzhavna sluzhba statystyky Ukrai'ny. Available at: http://www.ukrstat.gov.ua/
Kovalenko, V. M. (2011). Innovacijni naukovi tehnologii' v kardiologii'. Zhurn. NAMN Ukrai'ny, 17 (1), 7–10.
Roger, V. L., Go, A. S., Lloyd-Jones, D. M. et. al (2011). Heart disease and stroke statistics -2011 update: A report from the american heart. Circulation, 123, e18–e209.
Pearte, C. A. (2006). Characteristics and Baseline Clinical Predictors of Future Fatal Versus Nonfatal Coronary Heart Disease Events in Older Adults: The Cardiovascular Health Study. Circulation, 113 (18), 2177–2185. doi: 10.1161/circulationaha.105.610352
Shigemitsu, O., Hamada, T., Miyamoto, S. (2001). Early and long-term result of cardiovascular surgery in octogenarians. Annals of Thorac – Cardiovasc Surg, 4 (7), 22–31.
Tanaka, K., Ludwig, L. M., Kersten, J. R., Pagel, P. S., Warltier, D. C. (2004). Mechanisms of Cardioprotection by Volatile Anesthetics. Anesthesiology, 100 (3), 707–721. doi: 10.1097/00000542-200403000-00035
Alwaqfi, N. R., Khader, Y. S., Ibrahim, K. S. et al. (2012). Coronary artery bypass grafting: 30-day operative morbidity analysis in 1046 patients. Journal of Clinical Medicine Research, 4 (4), 267–273. doi: 10.4021/jocmr1020w
Downloads
Published
Issue
Section
License
Copyright (c) 2015 Александр Николаевич Дружина
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
