The perspective of polymers use as excipients in solid dosage forms production


  • Інна В’ячеславівна Ковалевська National University of Pharmacy 53 Pushkinska str., Kharkov, Ukraine, 61002, Ukraine
  • Олена Анатоліївна Рубан NationalUniversity of Pharmacy 53 Pushkinska str., Kharkov, Ukraine, 61002, Ukraine



technology, solid dosage forms, tablets, excipients, polymers, physical and chemical properties, use


Rational and scientifically grounded excipients selection is quite essential to increase the remedies competitiveness on the market. Excipients significantly affect the active pharmaceutical ingredients bioavailability and promote pharmacological activity. In development and upgrading of the solid dosage forms technology high molecular weight organic compounds, allowing creating drugs with predicted biopharmaceutical and technological parameters play a leading role recently. A wide range of new polymers allows creating the optimum conditions for implementation of activity of remedies with different chemical structures and action directions. The use of new, universal high molecular weight organic compounds create prerequisites for technological process optimization.

Aim. To determine modern polymers used in pharmacy, their physical and chemical properties, and the area of use.

Conclusion. Therefore, excipients diversification due to new generation of high molecular weight organic compounds create new possibilities for tableting process improvement and obtaining high quality remedies

Author Biographies

Інна В’ячеславівна Ковалевська, National University of Pharmacy 53 Pushkinska str., Kharkov, Ukraine, 61002

Candidate of pharmaceutical sciences, associate professor

Department of Industrial Technology of Drugs

Олена Анатоліївна Рубан, NationalUniversity of Pharmacy 53 Pushkinska str., Kharkov, Ukraine, 61002

Doctor of pharmaceutical sciences, professor

Department of Industrial Technology of Drugs


Duncan, R., Spreafico, F. (1994). Polymer Conjugates. Clinical Pharmacokinetics, 27 (4), 290–306. doi: 10.2165/00003088-199427040-00004

Alekseev, K. V., Kedik, S. A., Blynskayaetal, E. V. (2011). PharmaceuticalTechnology. Soliddosageforms. Moscow: PublishingHouse ZAO IPT., 662.

Conti, B., Pavanetto, F., Genta, I. (1991). Use of polylactic acid for the preparation of microparticulate drug delivery systems. Journal of Microencapsulation, 9 (2), 153–166. doi: 10.3109/02652049109021231

Ali, S. A. M., Doherty, P. J., Williams, D. F. (1994). Molecular biointeractions of biomedical polymers with extracellular exudate and inflammatory cells and their effects on the biocompatibility, in vivo. Biomaterials, 15 (10), 779–785. doi: 10.1016/0142-9612(94)90032-9

Chu, C. C. (1981). Thein-vitro degradation of poly(glycolic acid) sutures ? effect of pH. Journal of Biomedical Materials Research, 15 (6), 795–804. doi: 10.1002/jbm.820150604

Li, S. (1999). Hydrolytic degradation characteristic sofaliphatic polyesters derived from lactic and glycolic acids. Journal of Biomedical Materials Research, 48 (3), 342–353. doi: 10.1002/(sici)1097-4636(1999)48:3<342::aid-jbm20>;2-7

Bastoli, C. (Ed.) (2005). Hand book of Biodegradable Polymers. Shawbury: Rapra Technology Limited, 549.

Siepmann, J. (2001). Mathematical modeling of bioerodible, polymeric drug delivery systems. Advanced Drug Delivery Reviews, 48 (2-3), 229–247. doi: 10.1016/s0169-409x(01)00116-8

Gilding, D. K., Reed, A. M. (1979). Biodegradable polymers for use in surgery—polyglycolic/poly(actic acid) homo- and copolymers: 1. Polymer, 20 (12), 1459–1464. doi: 10.1016/0032-3861(79)90009-0

Gunatillake, P. A., Adhikari, R. (2003). Biodegradable synthetic polymers for tissue engineering. European Cellsand Materials, 20 (5), 1–16.

Schmitt, E. A., Flanagan, D. R., Linhardt, R. J. (1993). Degradation and release properties of pellets fabricated from three commercial poly(D,L-lactide-co-glycolide) biodegradable polymers. Journal of Pharmaceutical Sciences, 82 (3), 326–329. doi: 10.1002/jps.2600820322

Gad, S. C. (Ed.) (2008). Pharmaceutical Manufacturing Handbook: Productionand Processes. New Jersey: J. Wiley & Sons, 1370.

Garlotta, D. (2001). A literature review of poly (lactic acid). Journal of Polymers and the Environment, 9 (2), 63–84. doi: 10.1023/a:1020200822435

Alekseev, K. V., Gritskova, I. A., Kedik, S. A. (2011). Polymers for Pharmaceutical Technology. Moscow: Publishing House ZAO IPT., 511.





Pharmaceutical Sciences