Modern state of the assortment drugs for the treatment of vaginal candidosis

Authors

  • Юлия Валентиновна Левачкова National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraineб 61002,, Ukraine
  • Татьяна Григорьевна Ярных National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraineб 61002,, Ukraine
  • Валентина Николаевна Чушенко National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraineб 61002,, Ukraine
  • Снежана Николаевна Пушок National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraineб 61002,, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2015.56942

Keywords:

assortment, pharmaceutical market, marketing research, drugs, vaginal candidosis, fluconazole

Abstract

Today the problem of treatment of vaginal candidosis and creation of effective drugs for the treatment of this disease is actual for modern gynecology and pharmacy.

Aim: to explore the structure of the assortment of drugs for the treatment of vaginal candidosis, presented in the Ukrainian pharmaceutical market.

Methods: Statistical and marketing methods of investigation of electronic and paper sources of information. Implemented analysis assortment based on the materials of the State Register drugs in Ukraine and Compendium.

Results: in the treatment of vaginal candidosis greatest efficiency belongs fluconazole. According to the ATC classification drugs with fluconazole includes to 2 anatomical groups, among which the main proportion of drugs for systemic use. In the pharmaceutical market of Ukraine registered 103 drugs with a fluconazole, which are mainly represented by import manufacturers. The largest share of preparations (84.8%) constitute solid forms (capsules and tablets).

Conclusions: vaginal medications with fluconazole are not present. Considering that the suppositories have several advantages over other pharmaceutical forms, creation of the new drugs with fluconazole is a perspective direction for modern medicine and pharmacy

Author Biographies

Юлия Валентиновна Левачкова, National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraineб 61002,

Doctor of pharmaceutical sciences, associate professor

Department of technology of medicines

Татьяна Григорьевна Ярных, National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraineб 61002,

Doctor of pharmaceutical sciences, professor

Department of technology of medicines

Валентина Николаевна Чушенко, National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraineб 61002,

Candidate of pharmaceutical sciences, associate professor

Department of technology of medicines

References

Jarnyh, T. G., Levachkova, Ju. V., Chushenko, V. M., Skyter, S. M. (2014). Pat. na korysnu model' № U93885, MPK (2014) A 61K36/71, A61R15/02. Zasib u formi pesarii'v dlja likuvannja ginekologichnyh zahvorjuvan'. Zajavn. i patentovl. NFaU. № u 2014 03030; declared 25.03.14; published 27.10.2014. Bjul.. № 20, 4.

Dudko, V. L., Lahno, I. V., Storchak, A. V., Grishhenko, O. V., Dudko, L. V., Lisicina, N. V. (2006). Nekotorye aspekty jepidemiologii i perspektivy lechenija vaginal'nogo kandidoza v sovremennyh uslovijah. Visnik Harkivs'kogo nacional'nogo universitetu im. V. N. Karazina, 720. Ser.: Medicina, 12, 61–66.

Petersen, Je. Je. (2007). Infekcii v akusherstve i ginekologii. Moscow: MEDpress-inform, 104–112, 158–161.

Stock, I. (2010). Fungal diseases of vulva and vagina caused by Candida species. Med. Monatsschr. Pharm., 33 (9), 324–333.

Fedotov, V. P., Tuljakova, E. F., Gorbuncov, V. V., Mamon, A. A., Dzhybryl', V. A., Pylypenko, A. A., Korshun, Y. G. (2003). Pymafucyn v terapyy vagynal'nogo kandydoza. Ukrai'ns'kyj zhurnal dermatologii', venerologii', kosmetologii', 3, 81–82.

Reznichenko, N. O. (2005). Suchasna diagnostyka grybiv rodu Sandida. Bukovyns'kyj medychnyj visnyk, 9 (3), 161–165.

Evseev, A. A. (2009). Sovremennye principy diagnostiki i lechenija vaginal'nogo kandidoza. Vestnik reproduktivnogo zdorov’ja, 20–25.

Esim Buyukbayrak, E., Kars, B., Karsidag, A. Y. K., Karadeniz, B. I., Kaymaz, O., Gencer, S. et. al. (2010). Diagnosis of vulvovaginitis: comparison of clinical and microbiological diagnosis. Archives of Gynecology and Obstetrics, 282 (5), 515–519. doi: 10.1007/s00404-010-1498-x

Ilkit, M., Guzel, A. B. (2011). The epidemiology, pathogenesis, and diagnosis of vulvovaginal candidosis: A mycological perspective. Critical Reviews in Microbiology, 37 (3), 250–261. doi: 10.3109/1040841x.2011.576332

Ivleva, A. Ja., Poplavko, R. M., Leshkova, R. M., Grishkova, E. A. (1997). Medofljukon (fljukonazol) – poslednee dostizhenie v lechenii mikozov. Vestnik dermatologii i venerologii, 3, 63–66.

Mel'nykova, N. V., Fukleva, L. A., Puchkan, L. O., Zhadan, I. S., Loboda, O. S., Lytvynenko, T. M. (2010). Poshuk novyh likars'kyh zasobiv dlja suchasnoi' ginekologii'. Aktual'ni pytannja farmacevtychnoi' i medychnoi' nauky ta praktyky, 1, 61–63.

Skyter, S. M., Levachkova, Yu. V., Chushenko, V. M. (2014). Marketing researches of drugs on a fluconazole for a treatment of vaginal candidosis. Actual Questions Of Development of New Drugs: Abstracts of XX International Scientifi c And Practical Conference Of Young Scientists And Student. Kh.: Publishing Office, 115

Mihajlec, N. V., Svjatenko, T. V. (2010). Racional'nye podhody k vyboru mestnogo antimikoticheskogo sredstva. Ukrains'kij zhurnal dermatologіi, venerologіi, kosmetologіi, 1, 70–75.

European Pharmacopoeia. 5th ed. (2005). Suppl.4.4, 3503.

Kovalenko, V. N. (Ed.) (2013). Kompendium 2013 – lekarstvennye preparaty. Kyiv: Morion, 2360.

Derzhavnyj reestr likars'kyh zasobiv. Available at: http://www.drlz.kiev.ua/

Zamors'kyj, I. I. (2011). Systemni antymikotyky: mozhlyvosti farmakoterapii' v Ukrai'ni. Klinichna ta eksperymental'na patologija, 4, 157–158.

Levachkova, Ju. V., Chushenko, V. N., Pushok, S. N. (2015). Perspektivy razrabotki lekarstvennogo preparata na osnove masla amaranta dlja lechenija vospalitel'nyh ginekologicheskih zabolevanij. Tezisy VII mezhdunar. nauchno-prakticheskoj konf. «Academic science – problems and achievements». North Charleston, USA, 2, 224–225.

Levachkova, Ju. V. (2009). Zapal'ni zahvorjuvannja v ginekologii': klasyfikacija, etiologija, patogenez. Klinichna farmacija, 13 (3), 18–20.

Kosilova, S. Je. (2011). Poshuk novyh pryncypiv likuvannja hronichnogo kandydoznogo vul'vovaginitu. Klinichna ta eksperymental'na patologija, 4 (38), 168.

Kruts'kyh, T. V., Strilec', O. P., Bur’jan, K. O., Bur’jan, G. O. (2010). Pat. na vynahid № U91423. Farmacevtychna kompozycija u vygljadi vaginal'nyh supozytorii'v. Declared 17.11.2008; published 26.07.2010, Bjul. № 14.

Published

2015-12-29

Issue

Section

Pharmaceutical Sciences