Protective effect of new hygienic means on the oral mucous tunic at radial stomatitis
DOI:
https://doi.org/10.15587/2313-8416.2015.57352Keywords:
radial irradiation, mucous tunic, inflammation, antioxidant activity, reparationAbstract
The radial stomatitis development is the one of the main problems in patients who underwent radial therapy of the malignant tumors in head and neck region that impedes the effective antitumor treatment. The means of prophylaxis and local treatment of radial injuries are not always effective.
Aim of research. The determination of effectiveness of the new hygienic means based on antimatters on the state of oral mucous tunic at the radial stomatitis.
Materials and methods of research. Experiments were carried out on 42 white rats that were irradiated using AGAT-R-1 set with dose 7,5 gr. There were studied the picture of radial stomatitis in animals and an effect of the new hygienic mean on biochemical parameters of inflammation, peroxidation, antioxidant activity of the oral mucous tunic.
Results. At the local effect on the oral cavity tissue at radial stomatitis in rats the new hygienic mean ensures the elimination of manifestation of oxidative stress of irradiation and normalized an activity of antioxidant enzymes by 1,5 times faster than treatment in the control group. In the conditions of experiment the new gel had a local protective effect on the clinical course of erosive and ulcerous radial stomatitis and favored the healing of the oral mucous tunic wounds.
Conclusions. The received results indicate an availability of using new mean for the oral cavity care at the treatment of erosive and ulcerous element of OCMT radial injury
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