Functional myocardial state and the special features of left ventricle remodeling at chronic heart failure with diabetes mellitus type 2 on the background of overweight and obesity based on gender factor
DOI:
https://doi.org/10.15587/2313-8416.2016.58855Keywords:
heart failure, diabetes mellitus, obesity, gender, functional state, myocardium remodelingAbstract
Today chronic heart failure (CHF) is one of the main causes of death of patients with obesity and at the growth of body mass index (BMI) for every 1kg /m2 the risk of CHF increases by 5 % in men and by 7 % in women. There were proved that in the conditions of diabetes mellitus (DM) type 2 the mortality from cardiovascular pathology and especially CHF increases in 2-3 times in men and in 3-5 times in women. The aim of research was to study the myocardium functional state and the special features of the left ventricle (LV) remodeling at chronic heart failure (CHF) with diabetes mellitus (DM) type 2 on the background of overweight and obesity depending on gender factor.
Methods: there were examined 97 patients with CHF of I-III functional class at DM type 2 on the background of the normal body mass, overweight and abdominal obesity of I-III stage. All patients underwent echocardiographic examination. The processing of received data was carried out by the methods of nonparametric statistics.
Results: There was not revealed any reliable difference of index of LV ejection fraction that was a little less in men. The value of the mean pressure of pulmonary artery was almost equal and the prevalence of pulmonary hypertension unreliably predominated in men. The frequency of LV isolated systolic dysfunction (LVSD) in both groups did not essentially differ and LV diastolic dysfunction (LVDD) that was presented by myocardium relaxation disorder unreliably predominated in women. The percentage of combination of LVSD and LVDD had a tendency to increase in men. There was revealed reliable predominance of the frequency of LV hypertrophy (by 11 %) in women that in most cases was presented by its concentric type. The concentric LV remodeling observed in minority of patients unreliably predominated in men.
Conclusions: The myocardium functional changes at CHF with DM type 2 on the background of overweight and obesity are characterized with tendency to decrease of LV contractile ability, prevalence of pulmonary hypertension and predominance of systolic and diastolic dysfunction combination in men. Myocardium remodeling is presented by concentric type of LV hypertrophy and is more often registered in women
References
Drapkina, О. М., Korneeva, О. N., Palatkina, L. О. (2011). Adipokiny i serdechno-sosydictye zabolevania: patoheneticheskie paralleli I terapevticheskie perspektivy [Adipokines and cardiovascular disease: pathogenic parallels and therapeutic perspectives]. Arterial hypertension, 17 (3), 203–208.
O’Donnell, C. J., Elosua, R. (2008). Cardiovascular Risk Factors. Insights From Framingham Heart Study. Revista Española de Cardiología (English Edition), 61 (3), 299–310. doi: 10.1016/s1885-5857(08)60118-8
Spies, C., Farzaneh-Far, R., Na, B., Kanaya, A., Schiller, N. B., Whooley, M. A. (2009). Relation of Obesity to Heart Failure Hospitalization and Cardiovascular Events in Persons With Stable Coronary Heart Disease (from the Heart and Soul Study). The American Journal of Cardiology, 104 (7), 883–889. doi: 10.1016/j.amjcard.2009.05.027
Uretsky, S., Messerli, F. H., Bangalore, S., Champion, A., Cooper-DeHoff, R. M., Zhou, Q., Pepine, C. J. (2007). Obesity Paradox in Patients with Hypertension and Coronary Artery Disease. The American Journal of Medicine, 120 (10), 863–870. doi: 10.1016/j.amjmed.2007.05.011
Narizhna, А. V. (2014). Vzayemozviazok profibrotychnykh ta antifibrotychnykh markeriv u prohressuvanni kardiorenalnoho syndromu 2 typu na tli khronichnoi sertsevoi nedostatnosti i tsukrovoho diabetu 2 typu [The relationship of profibrotic and antifibrotic markers in the progression of cardiorenal syndrome 2 type on the background of chronic heart failure and diabetes mellitus type 2]. Clinical and experimental medicine, 2 (4), 153–156.
MacDonald, M. R., Eurich, D. T., Majumdar, S. R., Lewsey, J. D., Bhagra, S., Jhund, P. S. et. al (2010). Treatment of Type 2 Diabetes and Outcomes in Patients With Heart Failure: A Nested Case-Control Study From the U.K. General Practice Research Database. Diabetes Care, 33 (6), 1213–1218. doi: 10.2337/dc09-2227
Whiting, D. R., Guariguata, L., Weil, C., Shaw, J. (2011). IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Research and Clinical Practice, 94 (3), 311–321. doi: 10.1016/j.diabres.2011.10.029
Lind, M., Bounias, I., Olsson, M., Gudbjörnsdottir, S., Svensson, A.-M., Rosengren, A. (2011). Glycaemic control and incidence of heart failure in 20 985 patients with type 1 diabetes: an observational study. The Lancet, 378 (9786), 140–146. doi: 10.1016/s0140-6736(11)60471-6
Voronkov, L. H. et al. (2013). Rekomendacii po diahnostike I lecheniu khronicheskoi serdechnoi nedostatochnosti (2012) [Guidelines for the diagnosis and treatment of chronic heart failure (2012)]. Ukrainian cardiology journal, 1, 6–44.
Rundneva, E. A. (2008). Nadlezhashaia klinicheskaia praktika I issledovatel. Obshie princypy GCP ICH [Good clinical practice and the researcher. General principles of ICH GCP]. Ukr. med. chasopys,1 (63), 49–56.
Ginghină, C., Botezatu, C. D., Șerban, M., Jurcuț, R. (2011). A personalized medicine target: heart failure in women. Journal of Medicine and Life, 4 (3), 280–286.
Russo, C., Jin, Z., Palmieri, V., Homma, S., Rundek, T., Elkind, M. S. V. et. al (2012). Arterial Stiffness and Wave Reflection: Sex Differences and Relationship With Left Ventricular Diastolic Function. Hypertension, 60 (2), 362–368. doi: 10.1161/hypertensionaha.112.191148
Çil, H., Bulur, S., Türker, Y., Kaya, A., Alemdar, R., Karabacak, A. et. al (2012). Impact of Body Mass Index on Left Ventricular Diastolic Dysfunction. Echocardiography, 29 (6), 647–651. doi: 10.1111/j.1540-8175.2012.01688.x
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